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The Extracellular Matrix: an Overview pp 77–115Cite as

Collagens, Suprastructures, and Collagen Fibril Assembly

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Part of the book series: Biology of Extracellular Matrix ((BEM))

Abstract

Extracellular matrices are composed of collagens, proteoglycans, glycosaminoglycans, glycoproteins, and elastin. Extracellular matrix not only serves as structural scaffolds in organs and tissues, but also determines cellular function through cell–matrix interactions. Accordingly, the structures and organization of extracellular matrices are diverse and adapted to tissue-specific function. This chapter focuses on the collagen family. There are 28 different types of collagen that assemble into a variety of supramolecular structures including fibrils, microfibrils, and network-like structures. This chapter begins with a discussion of collagen molecules. This is followed by a definition of the supramolecular structure of different collagen types and their assembly and function within extracellular matrices. A discussion of general mechanistic principles involved in the assembly of collagen-containing suprastructures is presented. Finally, the regulation of tissue-specific collagen fibrillogenesis is used to illustrate how these general principles are applied in different tissues to generate the diversity in extracellular matrix structures and functions observed.

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Acknowledgments

Work from the author’s laboratories was supported by grants from the National Institutes of Health, EY05129, AR44745, and AR55543 as well as by grants from Deutsche Forschungsgemeinschaft, Collaborative Research Centre 492, Projects A2, B9, and B18. Andre Holmes is gratefully acknowledged for his help in preparing the illustrations and Sheila Adams for the preparation of the electron micrographs.

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Authors and Affiliations

  1. Department of Pathology and Cell Biology, University of South Florida, College of Medicine, 12901 Bruce B. Downs Boulevard, MDC11, Tampa, FL, 33612-4799, USA

    David E. Birk

  2. Institute for Physiological Chemistry and Pathobiochemistry, University Hospital of Münster, Waldeyerstr. 15, 48149, Münster, Germany

    Peter Brückner

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  1. David E. Birk
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  2. Peter Brückner
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Correspondence to David E. Birk .

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  1. School of Medicine, Dept. Cell Biology & Physiology, Washington University, S. Euclid Avenue 660, St. Louis, 63110, Missouri, USA

    Robert P. Mecham

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Birk, D.E., Brückner, P. (2011). Collagens, Suprastructures, and Collagen Fibril Assembly. In: Mecham, R. (eds) The Extracellular Matrix: an Overview. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16555-9_3

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