Skip to main content
SpringerLink
Log in
Book cover

Urinary Tract pp 45–67Cite as

Animal Models of Stress Urinary Incontinence

  • Chapter
  • First Online:

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 2011))

Abstract

Stress urinary incontinence (SUI) is a common health problem significantly affecting the quality of life of women worldwide. Animal models that simulate SUI enable the assessment of the mechanism of risk factors for SUI in a controlled fashion, including childbirth injuries, and enable preclinical testing of new treatments and therapies for SUI. Animal models that simulate childbirth are presently being utilized to determine the mechanisms of the maternal injuries of childbirth that lead to SUI with the goal of developing prophylactic treatments. Methods of assessing SUI in animals that mimic diagnostic methods used clinically have been developed to evaluate the animal models. Use of these animal models to test innovative treatment strategies has the potential to improve clinical management of SUI. This chapter provides a review of the available animal models of SUI, as well as a review of the methods of assessing SUI in animal models, and potential treatments that have been tested on these models.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • (2005) Duloxetine: new drug. For stress urinary incontinence: too much risk, too little benefit. Prescrire Int 14(80):218–220

    Google Scholar 

  • Aboushwareb T, Atala A (2008) Stem cells in urology. Nat Clin Pract Urol 5(11):621–631

    CAS  PubMed  Google Scholar 

  • Ahmed Y, Lin DL, Ferguson C, Esparza N, Damaser MS (2006) Effect of estrogen on urethral function and nerve regeneration following pudendal nerve crush in the female rat. J Urol 175(5):1948–1952

    CAS  PubMed  Google Scholar 

  • Ahn H, Lin DL, Esparza N, Damaser MS (2005) Short-term timecourse of bilateral pudendal nerve injury on leak-point pressure in female rats. J Rehabil Res Dev 42(1):109–114

    PubMed  Google Scholar 

  • Aroni F, Iacovidou N, Dontas I, Pourzitaki C, Xanthos T (2009) Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drug. J Clin Pharmacol 49(8):957–964

    CAS  PubMed  Google Scholar 

  • Bae JH, Moon DG, Lee JG (2001) The effects of a selective noradrenaline reuptake inhibitor on the urethra: an in vitro and in vivo study. BJU Int 88(7):771–775

    CAS  PubMed  Google Scholar 

  • Bernabe J, Julia-Guilloteau V, Denys P, Chartier-Kastler E, Alexandre L, Peeters M et al (2008) Peripheral neural lesion-induced stress urinary incontinence in anaesthetized female cats. BJU Int 102(9):1162–1167

    PubMed  Google Scholar 

  • Birnbaum HG, Leong SA, Oster EF, Kinchen K, Sun P (2004) Cost of stress urinary incontinence: a claims data analysis. Pharmacoeconomics 22(2):95–105

    PubMed  Google Scholar 

  • Cannon TW, Damaser MS (2001) Effects of anesthesia on cystometry and leak point pressure of the female rat. Life Sci 69:1193–1202

    CAS  PubMed  Google Scholar 

  • Cannon TW, Wojcik EM, Ferguson CL, Saraga S, Thomas C, Damaser MS (2002) Effects of vaginal distension on urethral anatomy and function. BJU Int 90(4):403–407

    CAS  PubMed  Google Scholar 

  • Cannon TW, Lee JY, Somogyi G, Pruchnic R, Smith CP, Huard J et al (2003) Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology 62(5):958–963

    PubMed  Google Scholar 

  • Cannon TW, Sweeney DD, Conway DA, Kamo I, Yoshimura N, Sacks M et al (2005) A tissue-engineered suburethral sling in an animal model of stress urinary incontinence. BJU Int 96(4):664–669

    PubMed  Google Scholar 

  • Carr LK, Steele D, Steele S, Wagner D, Pruchnic R, Jankowski R et al (2008) 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 19(6):881–883

    CAS  PubMed  Google Scholar 

  • Chen B, Wen Y, Zhang Z, Guo Y, Warrington JA, Polan ML (2006) Microarray analysis of differentially expressed genes in vaginal tissues from women with stress urinary incontinence compared with asymptomatic women. Hum Reprod 21(1):22–29

    CAS  PubMed  Google Scholar 

  • Chen CC, Hijaz A, Drazba JA, Damaser MS, Daneshgari F (2009) Collagen remodeling and suburethral inflammation might account for preserved anti-incontinence effects of cut polypropylene sling in rat model. Urology 73(2):415–420

    PubMed  Google Scholar 

  • Chermansky CJ, Cannon TW, Torimoto K, Fraser MO, Yoshimura N, de Groat WC et al (2004) A model of intrinsic sphincteric deficiency in the rat: electrocauterization. Neurourol Urodyn 23(2):166–171

    PubMed  Google Scholar 

  • Conway DA, Kamo I, Yoshimura N, Chancellor MB, Cannon TW (2005) Comparison of leak point pressure methods in an animal model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 16(5):359–363

    PubMed  Google Scholar 

  • Damaser MS, Broxton-King C, Ferguson C, Kim FJ, Kerns JM (2003) Functional and neuroanatomical effects of vaginal distention and pudendal nerve crush in the female rat. J Urol 170(3):1027–1031

    PubMed  Google Scholar 

  • Damaser MS, Whitbeck C, Chichester P, Levin RM (2005) Effect of vaginal distension on blood flow and hypoxia of urogenital organs of the female rat. J Appl Physiol 98(5):1884–1890

    CAS  PubMed  Google Scholar 

  • Damaser MS, Samplaski MK, Parikh M, Lin DL, Rao S, Kerns JM (2007) Time course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats. Am J Physiol Renal Physiol 293(5):F1614–F1621

    CAS  PubMed  Google Scholar 

  • DeLancey JO, Trowbridge ER, Miller JM, Morgan DM, Guire K, Fenner DE et al (2008) Stress urinary incontinence: relative importance of urethral support and urethral closure pressure. J Urol 179(6):2286–2290

    PubMed  Google Scholar 

  • Eberli D, Andersson KE, Yoo JJ, Atala A (2009) A canine model of irreversible urethral sphincter insufficiency. BJU Int 103(2):248–253

    PubMed  Google Scholar 

  • Evans JP (1936) Observations on the nerves of supply to the bladder and urethra of the cat, with a study of their action potentials. J Physiol 86(4):396–414

    CAS  PubMed  Google Scholar 

  • Foster HE, McGuire EJ (1993) Management of urethral obstruction with transvaginal urethrolysis. J Urol 150(5 Pt 1):1448–1451

    CAS  PubMed  Google Scholar 

  • Friedman B, Kleinfeld D, Ip NY, Verge VM, Moulton R, Boland P et al (1995) BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons. J Neurosci 15(2):1044–1056

    CAS  PubMed  Google Scholar 

  • Furuta A, Jankowski RJ, Pruchnic R, Yoshimura N, Chancellor MB (2007) The promise of stem cell therapy to restore urethral sphincter function. Curr Urol Rep 8(5):373–378

    PubMed  Google Scholar 

  • Haab F, Zimmern PE, Leach GE (1996) Female stress urinary incontinence due to intrinsic sphincteric deficiency: recognition and management. J Urol 156(1):3–17

    CAS  PubMed  Google Scholar 

  • Hampel C, Artibani W, Espuna PM, Haab F, Jackson S, Romero J et al (2004) Understanding the burden of stress urinary incontinence in Europe: a qualitative review of the literature. Eur Urol 46(1):15–27

    CAS  PubMed  Google Scholar 

  • Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J et al (2010) An international Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29(4):20

    Google Scholar 

  • Hijaz A, Daneshgari F, Cannon T, Damaser M (2004) Efficacy of a vaginal sling procedure in a rat model of stress urinary incontinence. J Urol 172(5 Pt 1):2065–2068

    PubMed  Google Scholar 

  • Hijaz A, Bena J, Daneshgari F (2005a) Long-term efficacy of a vaginal sling procedure in a rat model of stress urinary incontinence. J Urol 173(5):1817–1819

    PubMed  Google Scholar 

  • Hijaz A, Daneshgari F, Huang X, Bena J, Liu G, Saffore L et al (2005b) Role of sling integrity in the restoration of leak point pressure in the rat vaginal sling model. J Urol 174(2):771–775

    PubMed  Google Scholar 

  • Hijaz A, Daneshgari F, Sievert KD, Damaser MS (2008) Animal models of female stress urinary incontinence. J Urol 179(6):2103–2110

    PubMed  Google Scholar 

  • Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk PA, Rodriguez LV (2005) Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol 174(5):2041–2045

    CAS  PubMed  Google Scholar 

  • Jiang HH, Pan HQ, Gustilo-Ashby MA, Gill B, Glaab J, Zaszczurynski P et al (2009a) Dual simulated childbirth injuries result in slowed recovery of pudendal nerve and urethral function. Neurourol Urodyn 28(3):229–235

    PubMed  Google Scholar 

  • Jiang HH, Gustilo-Ashby AM, Salcedo LB, Pan HQ, Sypert DF, Butler RS et al (2009b) Electrophysiological function during voiding after simulated childbirth injuries. Exp Neurol 215(2):342–348

    PubMed  Google Scholar 

  • Julia-Guilloteau V, Denys P, Bernabe J, Mevel K, Chartier-Kastler E, Alexandre L et al (2007) Urethral closure mechanisms during sneezing-induced stress in anesthetized female cats. Am J Physiol Regul Integr Comp Physiol 293(3):R1357–R1367

    CAS  PubMed  Google Scholar 

  • Kaiho Y, Kamo I, Chancellor MB, Arai Y, de Groat WC, Yoshimura N (2007) Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol 292(2):F639–F646

    CAS  PubMed  Google Scholar 

  • Kamo I, Hashimoto T (2007) Involvement of reflex urethral closure mechanisms in urethral resistance under momentary stress condition induced by electrical stimulation of rat abdomen. Am J Physiol Renal Physiol 293(3):F920–F926

    CAS  PubMed  Google Scholar 

  • Kamo I, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N (2003) Urethral closure mechanisms under sneeze-induced stress condition in rats: a new animal model for evaluation of stress urinary incontinence. Am J Physiol Regul Integr Comp Physiol 285(2):R356–R365

    CAS  PubMed  Google Scholar 

  • Kamo I, Cannon TW, Conway DA, Torimoto K, Chancellor MB, de Groat WC et al (2004) The role of bladder-to-urethral reflexes in urinary continence mechanisms in rats. Am J Physiol Renal Physiol 287(3):F434–F441

    CAS  PubMed  Google Scholar 

  • Kamo I, Kaiho Y, Canon TW, Chancellor MB, de Groat WC, Prantil RL et al (2006) Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma. J Urol 176(6 Pt 1):2711–2715

    PubMed  Google Scholar 

  • Kane DD, Shott S, Hughes WF, Kerns JM (2002) Motor pudendal nerve characterization in the female rat. Anat Rec 266(1):21–29

    PubMed  Google Scholar 

  • Kane DD, Kerns JM, Lin DL, Damaser MS (2004) Early structural effects of oestrogen on pudendal nerve regeneration in the rat. BJU Int 93(6):870–878

    CAS  PubMed  Google Scholar 

  • Kefer JC, Liu G, Daneshgari F (2008) Pubo-urethral ligament transection causes stress urinary incontinence in the female rat: a novel animal model of stress urinary incontinence. J Urol 179(2):775–778

    PubMed  Google Scholar 

  • Kefer JC, Liu G, Daneshgari F (2009) Pubo-urethral ligament injury causes long-term stress urinary incontinence in female rats: an animal model of the integral theory. J Urol 181(1):397–400

    PubMed  Google Scholar 

  • Kerns JM, Damaser MS, Kane JM, Sakamoto K, Benson JT, Shott S et al (2000) Effects of pudendal nerve injury in the female rat. Neurourol Urodyn 19(1):53–69

    CAS  PubMed  Google Scholar 

  • Kim JH, Huang X, Liu G, Moore C, Bena J, Damaser MS et al (2007) Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats. Am J Physiol Regul Integr Comp Physiol 293(2):R950–R955

    CAS  PubMed  Google Scholar 

  • Kuo HC (2002) Effects of vaginal trauma and oophorectomy on the continence mechanism in rats. Urol Int 69(1):36–41

    PubMed  Google Scholar 

  • Kwon D, Kim Y, Pruchnic R, Jankowski R, Usiene I, de MF et al (2006) Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology 68(2):449–454

    PubMed  Google Scholar 

  • Lee JY, Cannon TW, Pruchnic R, Fraser MO, Huard J, Chancellor MB (2003) The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 14(1):31–37

    CAS  PubMed  Google Scholar 

  • Lee JY, Paik SY, Yuk SH, Lee JH, Ghil SH, Lee SS (2004) Long term effects of muscle-derived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves. Mol Cells 18(3):309–313

    CAS  PubMed  Google Scholar 

  • Lee UJ, Gustilo-Ashby AM, Daneshgari F, Kuang M, Vurbic D, Lin DL et al (2008) Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans. Am J Physiol Renal Physiol 295(2):F545–F555

    CAS  PubMed  Google Scholar 

  • li-El-Dein B, Ghoneim MA (2001) Effects of selective autonomic and pudendal denervation on the urethral function and development of retention in female dogs. J Urol 166(4):1549–1554

    Google Scholar 

  • Lin AS, Carrier S, Morgan DM, Lue TF (1998) Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology 52(1):143–151

    CAS  PubMed  Google Scholar 

  • Lin G, Shindel AW, Banie L, Deng D, Wang G, Hayashi N et al (2008a) Molecular mechanisms related to parturition-induced stress urinary incontinence. Eur Urol 55:1213–1223

    PubMed  Google Scholar 

  • Lin YH, Liu G, Daneshgari F (2008b) A mouse model of simulated birth trauma induced stress urinary incontinence. Neurourol Urodyn 27(4):353–358

    PubMed  Google Scholar 

  • Lin YH, Liu G, Li M, Xiao N, Daneshgari F (2010) Recovery of continence function following simulated birth trauma involves repair of muscle and nerves in the urethra in the female mouse. Eur Urol 57(3):512–513

    Google Scholar 

  • Lose G, Griffiths D, Hosker G, Kulseng-Hanssen S, Perucchini D, Schafer W et al, Standardization Sub-Committee, International Continence Society (2002) Standardization of urethral pressure measurement: report from the Standardization Sub-Committee of the International Continence Society. Neurourol Urodyn 21:258–260

    Google Scholar 

  • McGuire EJ (2004) Pathophysiology of stress urinary incontinence. Rev Urol 6(suppl 5):S11–S17

    PubMed  Google Scholar 

  • McKenna KE, Nadelhaft I (1986) The organization of the pudendal nerve in the male and female rat. J Comp Neurol 248(4):532–549

    CAS  PubMed  Google Scholar 

  • Miyazato M, Kaiho Y, Kamo I, Chancellor MB, Sugaya K, de Groat WC et al (2008) Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol 295(1):F264–F271

    CAS  PubMed  Google Scholar 

  • Nikolavsky D, Chancellor MB (2010) Stem cell therapy for stress urinary incontinence. Neurourol Urodyn 29(suppl 1):S36–S41

    PubMed  Google Scholar 

  • Olsen AL, Ross M, Stansfield RB, Kreiter C (2003) Pelvic floor nerve conduction studies: establishing clinically relevant normative data. Am J Obstet Gynecol 189(4):1114–1119

    PubMed  Google Scholar 

  • Pacheco P, Martinez-Gomez M, Whipple B, Beyer C, Komisaruk BR (1989) Somato-motor components of the pelvic and pudendal nerves of the female rat. Brain Res 490(1):85–94

    CAS  PubMed  Google Scholar 

  • Pan HQ, Kerns JM, Lin DL, Liu S, Esparza N, Damaser MS (2007) Increased duration of simulated childbirth injuries results in increased time to recovery. Am J Physiol Regul Integr Comp Physiol 292(4):R1738–R1744

    CAS  PubMed  Google Scholar 

  • Pan HQ, Kerns JM, Lin DL, Sypert D, Steward J, Hoover CR et al (2009) Dual simulated childbirth injury delays anatomic recovery. Am J Physiol Renal Physiol 296(2):F277–F283

    CAS  PubMed  Google Scholar 

  • Park JM, Bloom DA, McGuire EJ (1997) The guarding reflex revisited. Br J Urol 80(6):940–945

    CAS  PubMed  Google Scholar 

  • Partridge TA, Grounds M, Sloper JC (1978) Evidence of fusion between host and donor myoblasts in skeletal muscle grafts. Nature 273(5660):306–308

    CAS  PubMed  Google Scholar 

  • Pauwels E, De WS, Wyndaele JJ (2009) Evaluation of different techniques to create chronic urinary incontinence in the rat. BJU Int 103(6):782–785

    PubMed  Google Scholar 

  • Peng CW, Chen JJ, Chang HY, de Groat WC, Cheng CL (2006) External urethral sphincter activity in a rat model of pudendal nerve injury. Neurourol Urodyn 25(4):388–396

    PubMed  Google Scholar 

  • Petros PE (1998) The pubourethral ligaments–an anatomical and histological study in the live patient. Int Urogynecol J Pelvic Floor Dysfunct 9(3):154–157

    CAS  PubMed  Google Scholar 

  • Petros PE, Ulmsten UI (1990) An integral theory of female urinary incontinence. Experimental and clinical considerations. Acta Obstet Gynecol Scand Suppl 153:7–31

    CAS  PubMed  Google Scholar 

  • Phull H, Salkini M, Escobar C, Purves T, Comiter CV (2007) The role of angiotensin II in stress urinary incontinence: A rat model. Neurourol Urodyn 26(1):81–88

    CAS  PubMed  Google Scholar 

  • Rapp DE, Kobashi KC (2008) The evolution of midurethral slings. Nat Clin Pract Urol 5(4):194–201

    PubMed  Google Scholar 

  • Resplande J, Gholami SS, Graziottin TM, Rogers R, Lin CS, Leng W et al (2002) Long-term effect of ovariectomy and simulated birth trauma on the lower urinary tract of female rats. J Urol 168(1):323

    PubMed  Google Scholar 

  • Rodriguez LV, Chen S, Jack GS, de AF, Lee KW, Zhang R (2005) New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regul Integr Comp Physiol 288(5):R1332–R1338

    CAS  PubMed  Google Scholar 

  • Rovner ES, Wein AJ (2004) Treatment options for stress urinary incontinence. Rev Urol 6(suppl 3):S29–S47

    PubMed  Google Scholar 

  • Sakuma K, Watanabe K, Sano M, Uramoto I, Nakano H, Li YJ et al (2001) A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy. Brain Res 907(1–2):1–19

    CAS  PubMed  Google Scholar 

  • Schenk S, Mal N, Finan A, Zhang M, Kiedrowski M, Popovic Z et al (2007) Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells 25(1):245–251

    CAS  PubMed  Google Scholar 

  • Shoffstall AJ, Zaszczurynski PJ, Butler RS, Damaser MS (2008) Development of a device to standardize leak point pressure experiments in rats. Neurourol Urodyn 27(6):553

    PubMed  Google Scholar 

  • Sievert KD, Emre BM, Tsai T, Dahms SE, Nunes L, Lue TF (2001) The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part I: functional and structural change. J Urol 166(1):311–317

    CAS  PubMed  Google Scholar 

  • Sievert KD, Bakircioglu ME, Tsai T, Nunes L, Lue TF (2004) The effect of labor and/or ovariectomy on rodent continence mechanism–the neuronal changes. World J Urol 22(4):244–250

    PubMed  Google Scholar 

  • Snooks SJ, Barnes PR, Swash M (1984) Damage to the innervation of the voluntary anal and periurethral sphincter musculature in incontinence: an electrophysiological study. J Neurol Neurosurg Psychiatry 47(12):1269–1273

    CAS  PubMed  Google Scholar 

  • Snooks SJ, Swash M, Henry MM, Setchell M (1986) Risk factors in childbirth causing damage to the pelvic floor innervation. Int J Colorectal Dis 1(1):20–24

    CAS  PubMed  Google Scholar 

  • Snooks SJ, Swash M, Mathers SE, Henry MM (1990) Effect of vaginal delivery on the pelvic floor: a 5-year follow-up. Br J Surg 77(12):1358–1360

    CAS  PubMed  Google Scholar 

  • Sugaya K, Nishijima S, Miyazato M, Ogawa Y (2005) Central nervous control of micturition and urine storage. J Smooth Muscle Res 41(3):117–132

    PubMed  Google Scholar 

  • Sultan AH, Kamm MA, Hudson CN (1994) Pudendal nerve damage during labour: prospective study before and after childbirth. Br J Obstet Gynaecol 101(1):22–28

    CAS  PubMed  Google Scholar 

  • Takacs EB (2007) The potential use of cytokines and stem cell homing signals in the treatment of stress urinary incontinence. J Urol 177(4):1227–1228

    PubMed  Google Scholar 

  • Takahashi S, Chen Q, Ogushi T, Fujimura T, Kumagai J, Matsumoto S et al (2006) Periurethral injection of sustained release basic fibroblast growth factor improves sphincteric contractility of the rat urethra denervated by botulinum-a toxin. J Urol 176(2):819–823

    CAS  PubMed  Google Scholar 

  • Tetzschner T, Sorensen M, Jonsson L, Lose G, Christiansen J (1997) Delivery and pudendal nerve function. Acta Obstet Gynecol Scand 76(4):324–331

    CAS  PubMed  Google Scholar 

  • Thor KB, Katofiasc MA (1995) Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther 274(2):1014–1024

    CAS  PubMed  Google Scholar 

  • Thuroff JW, Bazeed MA, Schmidt RA, Tanagho EA (1982) Mechanisms of urinary continence: an animal model to study urethral responses to stress conditions. J Urol 127(6):1202–1206

    CAS  PubMed  Google Scholar 

  • Wallois F, Gros F, Masmoudi K, Larnicol N (1995) C-Fos-like immunoreactivity in the cat brainstem evoked by sneeze-inducing air puff stimulation of the nasal mucosa. Brain Res 687(1–2):143–154

    CAS  PubMed  Google Scholar 

  • Widdicombe JG (1995) Neurophysiology of the cough reflex. Eur Respir J 8(7):1193–1202

    CAS  PubMed  Google Scholar 

  • Williams ER, Klutke CG (2008) Stress urinary incontinence: the evolution of the sling. Expert Rev Med Devices 5(4):507–523

    PubMed  Google Scholar 

  • Woo LL, Hijaz A, Kuang M, Penn MS, Damaser MS, Rackley RR (2007) Over expression of stem cell homing cytokines in urogenital organs following vaginal distention. J Urol 177(4):1568–1572

    CAS  PubMed  Google Scholar 

  • Woo LL, Hijaz A, Pan HQ, Kuang M, Rackley RR, Damaser MS (2009) Simulated childbirth injuries in an inbred rat strain. Neurourol Urodyn 28(4):356–361

    PubMed  Google Scholar 

  • Wood HM, Kuang M, Woo L, Hijaz A, Butler RS, Penn M et al (2008) Cytokine expression after vaginal distention of different durations in virgin Sprague-Dawley rats. J Urol 180(2):753–759

    CAS  PubMed  Google Scholar 

  • Yan Q, Matheson C, Lopez OT, Miller JA (1994) The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor. J Neurosci 14(9):5281–5291

    CAS  PubMed  Google Scholar 

  • Yiou R, Dreyfus P, Chopin DK, Abbou CC, Lefaucheur JP (2002) Muscle precursor cell autografting in a murine model of urethral sphincter injury. BJU Int 89(3):298–302

    CAS  PubMed  Google Scholar 

  • Zeng X, Jack GS, Zhang R, Wu B, Rodriguez LV (2006) Treatment of SUI using adipose derived stem cells: Restoration of urethral function. J Urol 175(4):900

    Google Scholar 

  • Zhang Y, Bicek AD, Wang G, Timm GW (2010) Effects of periurethral neuromuscular electrical stimulation on the voiding frequency in rats. Int Urogynecol J Pelvic Floor Dysfunct 21(10):1279–1284

    Google Scholar 

  • Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13(12):4279–4295

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomedical Engineering Department, The Cleveland Clinic, 9500 Euclid Ave. ND20, Cleveland, OH, 44195, USA

    Hai-Hong Jiang & Margot S. Damaser

Authors
  1. Hai-Hong Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margot S. Damaser
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Margot S. Damaser .

Editor information

Editors and Affiliations

  1. Wake Forest University, Medical Center Blvd., Winston-Salem, 27157-1088, North Carolina, USA

    Karl-Erik Andersson

  2. Academic Medical Center, Dept. Pharmacology & Pharmacotherapy, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, Netherlands

    Martin C. Michel

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jiang, HH., Damaser, M.S. (2011). Animal Models of Stress Urinary Incontinence. In: Andersson, KE., Michel, M. (eds) Urinary Tract. Handbook of Experimental Pharmacology, vol 2011. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16499-6_3

Download citation

Publish with us

Policies and ethics

Search

Navigation