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Membrane-Based Nanotechnology and Drug Delivery

  • Mohammad AshrafuzzamanEmail author
  • Jack Tuszynski
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

Can we track life’s molecular processes within a living cell? Observing all its organelles, biomolecules, and even individual chemical species in the cellular environment is rapidly becoming possible in real time and with ever-increasing spatial resolution. This will help us to better understand the numerous mechanisms which allow life to emerge and to continue within the organism so that it behaves like a coherent whole. Moreover, environmental assaults, pathological changes, or any manifestations of biological disorder inside cells require sometimes prompt and at other times slow repair processes for life to endure and continue. Over the past several centuries, pharmacology has developed medicinal means to enable and assist patients to recover from both specific and non-specific diseases and health problems. Most of these medicines are destined to eventually find their way inside the cellular environment, where needed, to exert their action. A rather new area of technology in the service of pharmacology is called ‘targeted drug delivery’, and it is dedicated to improvement in the delivery of certain drugs to their target organs. Pharmaceutical companies and research laboratories in academia have been investing in this sector heavily, due to its early promise. Encouraging advances in specific areas, especially in regard to the outer cellular regions, have been made, but no considerable progress has so far been seen regarding the issue of drug delivery into specific sections or targets in a cellular interior environment.

Keywords

Silica Nanoparticles Membrane Thickness Membrane Disruption Bilayer Thickness Conductance Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.College of Science, Department of BiochemistryKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Cross Cancer Institute, Department of PhysicsUniversity of AlbertaEdmontonCanada

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