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Lipids in Membranes

  • Mohammad AshrafuzzamanEmail author
  • Jack Tuszynski
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

The most important components that make up cell membranes are various types of lipids. By cataloging lipid structures (referred to as lipidomics), eukaryotic cells have been found to invest substantial resources in generating various types of lipids. Cells use about 5 % of their genes to encode for the synthesis of these lipids. Lipids perform a few general functions. First of all, lipids are used for energy storage, principally as triacylglycerol and steryl esters, in lipid droplets. The matrix of cellular membranes is formed by polar lipids, which consist of a hydrophobic and a hydrophilic portion. Furthermore, lipids act as first and second messengers in signal transduction and molecular recognition processes.

Keywords

Antimicrobial Peptide Lipid Phase Steryl Ester Lamellar Phase Lipid Monolayer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ashrafuzzaman, Md.:, Department of Biochemistry, University of Alberta, unpublished (2007)Google Scholar
  2. 2.
    Ashrafuzzaman, Md., Tuszynski, J.A.: Ion Pore Formation in Membranes due to Complex Interactions Between Lipids and Antimicrobial Peptides or Biomolecules. In: Goddard, W., Brenner, D., Lyshevki, S., Iafrate, G. (eds.) Handbook on Nanoscience, Engineering and Nanotechnology. Taylor& Francis Group (in CRC press), Boca Raton (2011)Google Scholar
  3. 3.
    Ashrafuzzaman, Md., McElhaney, R.N., Andersen, O.S.: One antimicrobial peptide (gramicidin S) can affect the function of another (gramicidin A or alamethicin) via effects on the phospholipid bilayer. Biophys. J. 94, 21a (2008)Google Scholar
  4. 4.
    Ashrafuzzaman, Md., Koeppe, R.E., II, Andersen, O.S.: Lipid bilayer elasticity and intrinsic curvature as regulators of channel function: a comparative single molecule study. New J. Phys. (2011) (Accepted)Google Scholar
  5. 5.
    Ashrafuzzaman, Md., Tseng, C.-Y., Tuszynski, J.A.: Chemotherapy drugs form ion pores in membranes due to phyical interactions with lipids (2011) (Submitted)Google Scholar
  6. 6.
    Gawrisch, K., Parsegian, V.A., Hajduk, D.A., Tate, M.W., Gruner, S.M., Fuller, N.L., Rand, R.P.: Energetics of a hexagonal-lamellarhexagonal transition sequence in dioleoylphosphatidylethanolaminemembranes. Biochemistry 31, 2856–2864 (1992)Google Scholar
  7. 7.
    Gruner, S.M.: Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids. Proc. Natl. Acad. Sci. USA 82, 3665–3669 (1983)Google Scholar
  8. 8.
    Hinz, H.-J., Kuttenreich, H., Meyer, R., Renner, M., Frund, R., Koynova, R., Boyanov, A.I., Tenchov, B.G.: Stereochemistry and size of supar headgroups determine structure and phase behavior of glycolipid membranes: densitometric, calorimetric and X-ray studies. Biochemistry 30, 5125–5138 (1991)Google Scholar
  9. 9.
    Israelachvili, J.N., Marcelja, S., Horn, R.G.: Physical principles of membrane organization. Q. Rev. Biophys. 13, 121–200 (1980)Google Scholar
  10. 10.
    Jain, M.: Introduction to Biological Membranes, 2nd ed. Wiley, New York (1988)Google Scholar
  11. 11.
    Keller, S.L., Gruner, S.M., Gawrisch, K.: Small concentrations of alamethicin induce a cubic phase in bulk phosphatidylethanolamine mixtures. Biochim. Biophys. Acta 1127, 241–246 (1996)Google Scholar
  12. 12.
    Killian, J.A., de Kruijff, B.: The influence of proteins and peptides on the phase properties of lipids. Chem. Phys. Lipids 40, 259–284 (1986)Google Scholar
  13. 13.
    Killian, J.A., Burger, K.N., de Kruijff, B.: Phase separation and hexagonal \(H_{II}\) phase formation by gramicidins A, B and C in dioleoylphosphatidylcholine model membranes. A study on the role of the tryptophan residues. Biochim. Biophys. Acta 897, 269–284 (1987)Google Scholar
  14. 14.
    Kinnunen, P.K.J.: On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases. Chem. Phys. Lipids 81, 151–166 (1996)Google Scholar
  15. 15.
    Kirk, G.L., Gruner, S.M., Stein, D.L.: A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water system. Biochemistry 23, 1093–1102 (1984)Google Scholar
  16. 16.
    Kozlov, M.M., Leikin, S., Rand, R.P.: Bending, hydration and interstitial energies quantitatively account for the hexagonal-lamellar-hexagonal reentrant phase transition in dioleoylphosphatidylethanolamine. Biophys. J. 67, 1603–1611 (1994)Google Scholar
  17. 17.
    Kucerka, N., Tristram-Nagle, S., Nagle, J.F.: Closer look at structure of fully hydrated fluid phase DPPC bilayers. Biophys. J. 90, L83–L85 (2006)Google Scholar
  18. 18.
    Lewis, R.N.A.H., Mannock, D.A., McElhaney, R.N.: Membrane lipid molecular structure and polymorphism. Curr. Top. Membr. (Academic Press) 44, 25–102 (1997)Google Scholar
  19. 19.
    Luzzati, V.: X-ray Diffraction Studies of Lipid Water Systems. In: Chapman, D. (ed.) Biological Membranes: Physical Fact and Function, Vol. 1, pp. 71–123. Academic Press, London (1968)Google Scholar
  20. 20.
    Mannock, D.A., McElhaney, R.N.: Differential scanning calorimetric and X-ray diffraction studies of a series of synthetic \(\beta \)-D-galactosyl diacylglycerols. Biochem. Cell Biol. 69, 863–867 (1991)Google Scholar
  21. 21.
    Mannock, D.A., Lewis, R.N.A.H., Sen, A., McElhaney, R.N.: The physical properties of glycosyl diacylglycerols: calorimetric studies of a homologous series of 1,2-di-O-acyl-3-O-(\(\beta \)-D-glucopyranosyl)-sn-glycerols. Biochemistry 27, 6852–6859 (1988)Google Scholar
  22. 22.
    Mannock, D.A., Lewis, R.N.A.H., Sen, A., McElhaney, R.N.: Physical properties of glycosyl diacylglycerols. 1. Calorimetric studies of a homologous series of 1,2-di-O-acyl-3-O-(\(\beta \)-D-glucopyranosyl)-sn-glycerols. Biochemistry 29, 7790–7799 (1990)Google Scholar
  23. 23.
    Prenner, E.J., Lewis, R.N.A.H., Neuman, K.C., Gruner, S.M., Kondejewski, L.H., Hodges, R.S., McElhaney, R.N.: Nonlamellar phase induced by the interaction of gramicidin S with lipid bilayers. A possible relationship to membrane-disrupting activity. Biochemistry 36, 7906–7916 (1997)Google Scholar
  24. 24.
    Rand, R.P., Fuller, N.L.: Structural dimensions and their changes in a reentrant hexagonal-lamellar transition of phospholipids. Biophys. J. 66, 2127–2138 (1994)Google Scholar
  25. 25.
    Seddon, J.M.: structure of the inverted hexagonal (\(H_{II}\)) phase and nonlamellar phase transitions of lipids. Biochim. Biophys. Acta 1031, 1–69 (1990)Google Scholar
  26. 26.
    Shyamsunder, E., Gruner, S.M., Tate, M.W., Turner, D.C., So, P.T.C., Tilcock, C.P.S.: Observation of inverted cubic phase in hydrated dioleoylphosphatidylethanolaminemembranes. Biochemistry 27, 2332–2336 (1988)Google Scholar
  27. 27.
    Singer, S.J., Nicholson, G.L.: The fluid mosaic model of the structure of cell membranes. Cell membranes are viewed as two dimensional solutions of oriented globular proteins and lipids. Science 175, 720–731 (1972)Google Scholar
  28. 28.
    Sud, M. et al.: LMSD: Lipid MAPS structure database. Nucleic Acids Res. 35, D527–D532 (2007)Google Scholar
  29. 29.
    Takahashi, H., Sinoda, K., Hatta, I.: Effects of cholesterol on the lamellar and the inverted hexagonal phases of dielaidoylphosphatidylethanolamine. Biochim. Biophys. Acta 1289, 209–216 (1996)Google Scholar
  30. 30.
    Tournois, H., Fabrie, C.H., Burger, K.N., Mandersloot, J., Hilgers, P., Van Dalen, H., De Geir, J., De Kruijff, B.: Biochemistry 29, 8297–8307 (1990)Google Scholar
  31. 31.
    van Meer, G.: Cellular lipidomics. EMBO J. 24, 3159–3165 (2005)Google Scholar
  32. 32.
    van Meer, G., Voelker, D.R., Feigenson, G.W.: Membrane lipids: where they are and how they behave. Nature Rev. Mol. Cell Biol. 9, 112–124 (2008)Google Scholar
  33. 33.
    Zhang, Y.-P., Lewis, R.N.A.H., Hodges, R.S., McElhaney, R.N.: Peptide models of the helical hydrophobic transmembrane segments of membrane proteins: interactions of acetyl-\({\rm K}_2\)-\(\text{(LA)}_{12}\)-\({\rm K}_2\)-amide with phosphatidylethanolamine bilayer membranes. Biochemistry 40(2), 474482 (2001)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Biochemistry, College of ScienceKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of Physics, Cross Cancer InstituteUniversity of AlbertaEdmontonCanada

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