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Surgical Resection for Hepatocellular Carcinoma in the Noncirrhotic: The Western Experience

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Multidisciplinary Treatment of Hepatocellular Carcinoma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 190))

Abstract

Although hepatocellular carcinoma (HCC) is most often a sequela of severe hepatic fibrosis or cirrhosis, a proportion of cases arise in the noncirrhotic patient. The gold standard therapy in such cases is surgical resection. Innovations in operative technique allow for this treatment to be implemented with very low mortality and acceptable morbidity at high-volume hepatobiliary centers. This chapter discusses various etiologies of noncirrhotic HCC and presents a large single-center experience that is compared to other Western series.

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Abbreviations

AASLD:

American Association for the Study of Liver Diseases

AFP:

Alpha-fetoprotein IVF, intravenous fluid

ALT:

Alanine aminotransferase IOUS, intraoperative ultrasound

AST:

Aspartate aminotransferase NAFLD, nonalcoholic fatty liver disease

CVP:

Central venous pressure NASH, nonalcoholic steatohepatitis

DM:

Diabetes mellitus OLT, orthotopic liver transplantation

FLR:

Future liver remnant OS, overall survival

FLV:

Future liver volume PPV, positive predictive value

HCC:

Hepatocellular carcinoma PV, portal vein

HBV:

Hepatitis B virus PVE, portal vein embolization

HBsAg:

Hepatitis B surface antigen RFA, radiofrequency ablation

HCV:

Hepatitis C virus RFS, recurrence-free survival

HVE:

Hepatic vascular exclusion RR, relative risk

HVPG:

Hepatic venous pressure gradient TACE, transarterial chemoembolization

ICG:

Indocyanine green TLV, total liver volume

IVC:

Inferior vena cava TTR, time to recurrence

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Acknowledgments

The authors wish to acknowledge the invaluable contribution of Ghalib Jibara, M.D., M.P.H. in the preparation of this chapter.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1104, NewYork, NY, 10029-6574, USA

    Myron E. Schwartz & Brian Shrager

Authors
  1. Myron E. Schwartz
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  2. Brian Shrager
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Corresponding author

Correspondence to Myron E. Schwartz .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Dept. Surgical Oncology, University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Jean-Nicolas Vauthey

  2. , Dept. of Surgical Oncology, MD Anderson Cancer Center, Holcombe Boulevard, Unit 444 1515, Houston, 77030, USA

    Antoine Brouquet

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Schwartz, M.E., Shrager, B. (2013). Surgical Resection for Hepatocellular Carcinoma in the Noncirrhotic: The Western Experience. In: Vauthey, JN., Brouquet, A. (eds) Multidisciplinary Treatment of Hepatocellular Carcinoma. Recent Results in Cancer Research, vol 190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16037-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-16037-0_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-16036-3

  • Online ISBN: 978-3-642-16037-0

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