Abstract
Impaired systolic ventricular function is common in patients diagnosed with heart failure (HF) or ischaemic heart disease. The diminished contractile performance with impaired contractility (systolic HF) can be induced by impaired filling function (diastolic HF) and the wall stress (both passive and active) may indicate the progression from diastolic HF to systolic HF. In order to better understand the distribution of active stress during ventricular contraction, a left ventricular (LV) finite element (FE) model incorporating LV fibre geometry and function was developed to parameterise a time-varying model of myocardial contraction by simulating LV mechanics. During systole, the isometric active stress monotonically increased to 95 kPa, and rapidly recovered during isovolumic relaxation. We also observed regional variations of the fibre length dependent contractile stress throughout the LV. The time-varying active stress curve thereby obtained enabled quantification of heart muscle performance. This type of integrative modelling enables the investigation of LV mechanics on an individualised basis.
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References
Moulton, M.J., Creswell, L.L., Downing, S.W., Actis, R.L., Szabo, B.A., Pasque, M.K.: Myocardial material property determination in the in vivo heart using magnetic resonance imaging. Int. J. Card. Imaging 12, 153–167 (1996)
Linzbach, A.J.: Heart failure from the point of view of quantitative anatomy. Am. J. Cardiol. 5, 370–382 (1960)
Grossman, W., Jones, D., McLaurin, L.P.: Wall Stress and Patterns of Hypertrophy in the Human Left Ventricle. J. Clin. Invest. 56, 56–64 (1975)
Meerson, F.Z.: The myocardium in Hyperfunction and Heart Failure. Circ. Res. 25 (1969)
Carabello, B.A., Nolan, S.P., McGuire, L.B.: Assessment of Preoperative Left Ventricular Function in Patients with Mitral Regurgitation: Value of the End-systolic Wall Stress-End-Systolic Volume Ratio. Circulation 64, 1212–1217 (1981)
Costa, K.D., Holmes, J.W., McCulloch, A.D.: Modelling cardiac mechanical properties in three dimensions. Phil. Trans. Royal. Soc. Lond. 359, 1233–1250 (2001)
Demer, L.L., Yin, F.C.: Passive biaxial mechanical properties of isolated canine myocardium. J. Physiol. 339, 615–630 (1983)
Wang, V.Y., Lam, H.I., Ennis, D.B., Young, A.A., Nash, M.P.: Passive Ventricular Mechanics Modelling Using MRI of Structure and Function. In: Metaxas, D., Axel, L., Fichtinger, G., Székely, G. (eds.) MICCAI 2008, Part II. LNCS, vol. 5242, pp. 814–821. Springer, Heidelberg (2008)
Wang, V.Y., Lam, H.I., Ennis, D.B., Cowan, B.R., Young, A.A., Nash, M.P.: Modelling Passive Diastolic Mechanics with Quantative MRI of Cardiac Structure and Function. Med. Image. Anal. 13, 773–784 (2009)
Nielsen, P.M.F.: The anatomy of the heart: A finite element model. PhD Thesis, Vol. PhD. The University of Auckland (1987)
Nash, M.P., Hunter, P.J.: Computational Mechanics of the heart. J. Elast. 61, 113–141 (2000)
Guccione, J.M., McCulloch, A.D., Waldman, L.K.: Passive material properties of intact ventricular myocardium determined from a cylindrical model. J. Biomech. Eng. 113, 43–55 (1991)
Hunter, P.J., McCulloch, A.D., ter Keurs, H.E.D.J.: Modelling the mechanical properties of cardiac muscle. Prog. Biophys. Mol. Biol. 69, 289–331 (1998)
Walker, J.C., Ratcliffe, M.B., Zhang, P., Wallace, A.W., Edward, B.F., Hsu, W., Saloner, D.A., Guccione, J.M.: Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. Am. J. Physio. Heart. Circ. Physiol. 289, H692–H700 (2004)
Niederer, S.A., Hunter, P.J., Smith, N.P.: A quantitative analysis of cardiac myocyte relaxation: a simulation study. Biophys. J. 90(5), 1697–1722 (2006)
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Wang, V.Y., Lam, H.I., Ennis, D.B., Cowan, B.R., Young, A.A., Nash, M.P. (2010). Cardiac Active Contraction Parameters Estimated from Magnetic Resonance Imaging. In: Camara, O., Pop, M., Rhode, K., Sermesant, M., Smith, N., Young, A. (eds) Statistical Atlases and Computational Models of the Heart. STACOM 2010. Lecture Notes in Computer Science, vol 6364. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15835-3_20
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DOI: https://doi.org/10.1007/978-3-642-15835-3_20
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