Skip to main content
SpringerLink
Log in
Book cover

International Workshop on Statistical Atlases and Computational Models of the Heart

STACOM 2010: Statistical Atlases and Computational Models of the Heart pp 164–173Cite as

Investigating Heart Failure Using Ventricular Imaging and Modelling

  • Conference paper

  • 968 Accesses

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 6364))

Abstract

It is well-established that ventricular hypertrophy is a transitional phase through the development of heart failure. A hypertrophic heart can remodel to compensate the loss of pump function, but it eventually becomes incapable of working efficiently, leading to heart failure. Many heart failure patients have preserved pump function (e.g. normal ejection fraction), but increased LV wall thickness and sometimes increased LV mass, which can mask a decrease in contractility. Alterations in the myofibre structure and myocardial material properties can potentially account for the progression of heart failure. We have developed a canine LV finite element model to investigate the effect of ventricular size, myocardial passive material properties, and cardiac contractility on the LV mechanical performance. By comparing mechanical function of normal and abnormal LVs, due to dilation and/or loss of anisotropy and/or reduced contractility, we found that dilation and compromised muscle contractility decreased most indices of cardiac performance. This modelling framework provides insight into the underlying mechanisms of heart failure.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wang, J., Nagueh, S.F.: Current perspectives on cardiac function in patients with diastolic heart failure. Circ. 119, 1146–1157 (2009)

    Article  Google Scholar 

  2. Pope, A., Sands, G.B., Smaill, B.H., LeGrice, I.J.: Three dimensional transmural organization of perimysial collagen in the rat heart. Am. J. Physiol. Heart Circ. Physiol. 295, H1243–H1252 (2008)

    Article  Google Scholar 

  3. Gilbert, S.H., Benson, A.P., Li, P., Holden, A.V.: Regional loacalisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure. Eur. J. Cardiothorac. Surg. 32, 231–249 (2007)

    Article  Google Scholar 

  4. LeGrice, I.J., Smaill, B.H., Chai, L., Edgar, S., Gavin, J., Hunter, P.J.: Laminar structure of the heart: ventricular myocyte arrangment and connective tissue architecture in the dog. Am. J. Physiol. Heart. Circ. Physiol. 269, H571–H582 (1995)

    Google Scholar 

  5. Costa, K., Takayama, Y., McCulloch, A.D., Covell, J.W.: Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium. Am. J. Physiol. Heart Circ. Physiol. 283, H2650–H2659 (1999)

    Google Scholar 

  6. Nash, M.P., Hunter, P.J.: Computational mechanics of the heart: From tissue structure to ventricular function. J. Elasticity 61, 113–141 (2000)

    Article  MATH  MathSciNet  Google Scholar 

  7. LeGrice, I.J., Pope, A.M., Sands, G.B., Smaill, B.H.: Perimysial collagen remodelling and mechanical dysfunction in hypertensive cardiomyopathy (2010) (under review)

    Google Scholar 

  8. Wang, V.Y., Lam, H.I., Ennis, D.B., Young, A.A., Nash, M.P.: Passive ventricular mechanics modelling using MRI of structure and function. In: Metaxas, D., Axel, L., Fichtinger, G., Székely, G. (eds.) MICCAI 2008, Part II. LNCS, vol. 5242, pp. 814–821. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  9. Ennis, D.B.: Assessment of myocardial structure and function using magnetic resonance imaging. PhD Thesis. John Hopkins University (2004)

    Google Scholar 

  10. Le Bihan, D., Mangin, J.F., Poupon, C., Clark, C.A., Pappata, S., Molko, N., Chabriat, H.: Diffusion tensor imaging: concepts and applications. J. Magn. Reson. Imaging 13, 534–546 (2001)

    Article  Google Scholar 

  11. Nielsen, P., LeGrice, I.J., Smaill, B.H., Hunter, P.J.: Mathematical model of geometry and fibrous structure of the heart. Am. J. Physiol. Heart Circ. Physiol. 260, H1365–H1378 (1991)

    Google Scholar 

  12. Wang, V.Y., Lam, H.I., Ennis, D.B., Young, A.A., Nash, M.P.: Modelling passive diastolic mechanics with quantative MRI of cardiac structure and function. Med. Image Anal. 13, 773–784 (2009)

    Article  Google Scholar 

  13. Hunter, P.J., McCulloch, A.D., ter Keurs, H.E.D.J.: Modelling the mechanical properties of cardiac muscle. Prog. Biophys. Mol. Biol. 69, 289–331 (1998)

    Article  Google Scholar 

  14. Sipido, K.R., Volders, P.G.A., Marieke de Groot, S.H., Verdonck, F., Van de Werf, F., Wellens, H.J.J., Vos, M.A.: Enhanced Ca2+ Release and Na/CA Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link between Contractile Adaptation and Arrhythmogenesis. Circ. 102, 2137–2144 (2000)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Auckland Bioengineering Institute, University of Auckland, New Zealand

    Vicky Y. Wang, Alistair A. Young & Martyn P. Nash

  2. Centre for Advanced MRI, University of Auckland, 85 Grafton Road, Auckland, 1142, New Zealand

    Alistair A. Young

  3. Department of Engineering Science, University of Auckland, Level3, UniServices House, 70 Symonds Street, Auckland, 1142, New Zealand

    Martyn P. Nash

Authors
  1. Vicky Y. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alistair A. Young
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martyn P. Nash
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra, c/ Tanger, 122-140, 08018, Barcelona, Spain

    Oscar Camara

  2. Sunnybrook Health Sciences Centre, Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, Canada

    Mihaela Pop

  3. Division of Imaging Sciences, St. Thomas Hospital, King’s College London, SE1 7EH, London, UK

    Kawal Rhode

  4. INRIA, Asclepios Research Project, route des Lucioles, 06902, Sophia Antipolis, France

    Maxime Sermesant

  5. Computing Laboratory, University of Oxford, Wolfson Building, Parks Road, OX1 3QD, Oxford, UK

    Nic Smith

  6. School of Medical Sciences, The University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand

    Alistair Young

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Wang, V.Y., Young, A.A., Nash, M.P. (2010). Investigating Heart Failure Using Ventricular Imaging and Modelling. In: Camara, O., Pop, M., Rhode, K., Sermesant, M., Smith, N., Young, A. (eds) Statistical Atlases and Computational Models of the Heart. STACOM 2010. Lecture Notes in Computer Science, vol 6364. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15835-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-15835-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-15834-6

  • Online ISBN: 978-3-642-15835-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Search

Navigation