Skip to main content

Using an Artificial Neural Network to Determine Electrical Properties of Epithelia

  • Conference paper
  • 1824 Accesses

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 6352))

Abstract

The present study introduces a new approach for modeling electrical properties of epithelia. Artificial neural networks (ANNs) are used to estimate key parameters that otherwise can only be measured directly by applying complex and time-consuming laboratory methods. Assuming an electrical model equivalent to an epithelial layer, an ANN can be trained to learn the relation between these parameters and experimentally obtained impedance spectra. We demonstrate that even with a naive ANN our approach reduces the error rate of parameter estimation to less than 20 per cent. Successful test runs provide a proof of concept.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Krug, S.M., Fromm, M., Günzel, D.: Two-path Impedance Spectroscopy for Measuring Paracellular and Transcellular Epithelial Resistance. Biophys. J. 97(8), 2202–2211 (2009)

    Article  Google Scholar 

  2. Bertrand, C.A., et al.: System for Dynamic Measurements of Membrane Capacitance in Intact Epithelial Monolayers. Biophys. J. 75(6), 2743–2756 (1998)

    Article  Google Scholar 

  3. Gitter, A.H., Fromm, M., Schulzke, J.D.: Impedance Analysis for the Determination of Epithelial and Subepithelial Resistance in Intestinal Tissues. J. Biochem. Biophys. Methods 37(1-2), 35–46 (1998)

    Article  Google Scholar 

  4. Clausen, C., Lewis, S.A., Diamond, J.M.: Impedance Analysis of a Tight Epithelium Using a Distributed Resistance Model. Biophys. J. 26(2), 291–317 (1979)

    Article  Google Scholar 

  5. Mohraz, K., Arras, M.K.: FORWISS Artificial Neural Network Simulation Toolbox. Bavarian Reserach Center for Knowledge-Based Systems (1996)

    Google Scholar 

  6. Mohraz, K., Protzel, P.: FlexNet - A Flexible Neural Network Construction Algorithm. In: 4th European Symposium on Artificial Neural Networks, pp. 111–116 (1996)

    Google Scholar 

  7. Kavzoglu, T., Mather, P.M.: The Role of Feature Selection in Artificial Neural Network Applications. Int. J. Remote Sens. 23(15), 2919–2937 (2001)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schmid, T., Günzel, D., Bogdan, M. (2010). Using an Artificial Neural Network to Determine Electrical Properties of Epithelia. In: Diamantaras, K., Duch, W., Iliadis, L.S. (eds) Artificial Neural Networks – ICANN 2010. ICANN 2010. Lecture Notes in Computer Science, vol 6352. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15819-3_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-15819-3_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-15818-6

  • Online ISBN: 978-3-642-15819-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics