Abstract
The quantification of brain asymmetries may provide biomarkers for presurgical localization of language function and can improve our understanding of neural structure-function relationships in health and disease. We propose a new method for studying the asymmetry of the white matter tracts in the entire brain, and we apply it to a preliminary study of normal subjects across the handedness spectrum. Methods for quantifying white matter asymmetry using diffusion MRI tractography have thus far been based on comparing numbers of fibers or volumes of a single fiber tract across hemispheres. We propose a generalization of such methods, where the “number of fibers” laterality measurement is extended to the entire brain using a soft fiber comparison metric. We summarize the distribution of fiber laterality indices over the whole brain in a histogram, and we measure properties of the distribution such as its skewness, median, and inter-quartile range. The whole-brain fiber laterality histogram can be measured in an exploratory fashion without hypothesizing asymmetries only in particular structures. We demonstrate an overall difference in white matter asymmetry in consistent- and inconsistent-handers: the skewness of the fiber laterality histogram is significantly different across handedness groups.
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References
Toga, A., Thompson, P.: Mapping brain asymmetry. Nature Reviews Neuroscience 4(1), 37–48 (2003)
Catani, M., Allin, M., Husain, M., Pugliese, L., Mesulam, M., Murray, R., Jones, D.: Symmetries in human brain language pathways correlate with verbal recall. Proceedings of the National Academy of Sciences 104(43), 17163 (2007)
Good, C., Johnsrude, I., Ashburner, J., Henson, R., Friston, K., Frackowiak, R.: Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14(3), 685–700 (2001)
Buchel, C., Raedler, T., Sommer, M., Sach, M., Weiller, C., Koch, M.: White matter asymmetry in the human brain: a diffusion tensor MRI study. Cerebral Cortex 14(9), 945 (2004)
Park, H., Westin, C., Kubicki, M., Maier, S., Niznikiewicz, M., Baer, A., Frumin, M., Kikinis, R., Jolesz, F., McCarley, R., et al.: White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage 23(1), 213–223 (2004)
Glasser, M., Rilling, J.: DTI tractography of the human brain’s language pathways. Cerebral Cortex 18(11), 2471 (2008)
Guye, M., Parker, G., Symms, M., Boulby, P., Wheeler-Kingshott, C., Salek-Haddadi, A., Barker, G., Duncan, J.: Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo. Neuroimage 19(4), 1349–1360 (2003)
Eluvathingal, T., Hasan, K., Kramer, L., Fletcher, J., Ewing-Cobbs, L.: Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents. Cerebral Cortex 17(12), 2760 (2007)
Nucifora, P., Verma, R., Melhem, E., Gur, R., Gur, R.: Leftward asymmetry in relative fiber density of the arcuate fasciculus. Neuroreport 16(8), 791 (2005)
Amunts, K., Jancke, L., Mohlberg, H., Steinmetz, H., Zilles, K.: Interhemispheric asymmetry of the human motor cortex related to handedness and gender. Neuropsychologia 38(3), 304–312 (2000)
Vernooij, M., Smits, M., Wielopolski, P., Houston, G., Krestin, G., Van der Lugt, A.: Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right-and left-handed healthy subjects: a combined fMRI and DTI study. Neuroimage 35(3), 1064–1076 (2007)
Hagmann, P., Cammoun, L., Martuzzi, R., Maeder, P., Clarke, S., Thiran, J., Meuli, R.: Hand preference and sex shape the architecture of language networks. Human Brain Mapping 27(10), 828 (2006)
Wassermann, D., Bloy, L., Kanterakis, E., Verma, R., Deriche, R.: Unsupervised white matter fiber clustering and tract probability map generation: Applications of a Gaussian process framework for white matter fibers. Neuroimage (2010)
O’Donnell, L., Westin, C.: Automatic tractography segmentation using a high-dimensional white matter atlas. IEEE Transactions on Medical Imaging 26(11), 1562 (2007)
Barrick, T., Lawes, I., Mackay, C., Clark, C.: White matter pathway asymmetry underlies functional lateralization. Cerebral Cortex 17(3), 591 (2007)
Oldfield, R.: The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1), 97–113 (1971)
Zollei, L., Learned-Miller, E., Grimson, E., Wells, W.: Efficient population registration of 3D data. In: Liu, Y., Jiang, T.-Z., Zhang, C. (eds.) CVBIA 2005. LNCS, vol. 3765, pp. 291–301. Springer, Heidelberg (2005)
Gong, G., Jiang, T., Zhu, C., Zang, Y., Wang, F., Xie, S., Xiao, J., Guo, X.: Asymmetry analysis of cingulum based on scale-invariant parameterization by diffusion tensor imaging. Human Brain Mapping 24(2), 92–98 (2005)
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O’Donnell, L.J. et al. (2010). The Fiber Laterality Histogram: A New Way to Measure White Matter Asymmetry. In: Jiang, T., Navab, N., Pluim, J.P.W., Viergever, M.A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010. MICCAI 2010. Lecture Notes in Computer Science, vol 6362. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15745-5_28
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DOI: https://doi.org/10.1007/978-3-642-15745-5_28
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