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Respiratory Symptoms Occurring 4 Months After Allogeneic Hematopoietic Stem Cell Transplantation

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Pulmonary Involvement in Patients with Hematological Malignancies

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Abstract

Bronchiolitis obliterans (BO) is the most frequent late-onset noninfectious pulmonary complication following an allogeneic hematologic stem cell transplantation attributed to chronic lung graft-versus-host disease. Its management is usually a great challenge when considering both the diagnosis and the treatment. The definite diagnosis relies on histological examination; however, lung biopsies are rarely available. The diagnosis must then be retained for converging arguments based on clinical and radiological features and pulmonary function testing. However, clinical, radiological and functional characteristics of patients with BO may be various, leading to difficulties in diagnosis. Furthermore, the treatment of BO is currently a controversial issue, and its evaluation is limited by not knowing the natural history. Herein, through a demonstrative case study, we discuss the diagnostic and therapeutic approach for a patient with a biopsy-proven BO following allogeneic stem cell transplantation.

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Authors and Affiliations

  1. Université Paris 7, UFR Denis Diderot; Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Saint-Louis, 1, Avenue Claude Vellefaux, 75475, Paris Cedex 10, France

    Anne Bergeron, Séverine Feuillet & Abdellatif Tazi

  2. Université Paris 7, UFR Denis Diderot; Assistance Publique-Hôpitaux de Paris, Service de Pathologie, Hôpital Saint-Louis, Paris, France

    Véronique Meignin

  3. Université Paris 7, UFR Denis Diderot; Assistance Publique-Hôpitaux de Paris, Service d’Hématologie-Greffe, Hôpital Saint-Louis, Paris, France

    Patricia Ribaud

Authors
  1. Anne Bergeron
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  2. Séverine Feuillet
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  3. Véronique Meignin
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  4. Patricia Ribaud
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  5. Abdellatif Tazi
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Corresponding author

Correspondence to Anne Bergeron .

Editor information

Editors and Affiliations

  1. Service de Réanimation Médicale, Hôpital Saint Louis, Avenue Claude Vellefaux 1, Paris, 75010, France

    Elie Azoulay

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© 2011 Springer-Verlag Berlin Heidelberg

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Bergeron, A., Feuillet, S., Meignin, V., Ribaud, P., Tazi, A. (2011). Respiratory Symptoms Occurring 4 Months After Allogeneic Hematopoietic Stem Cell Transplantation. In: Azoulay, E. (eds) Pulmonary Involvement in Patients with Hematological Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15742-4_58

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  • DOI: https://doi.org/10.1007/978-3-642-15742-4_58

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-15741-7

  • Online ISBN: 978-3-642-15742-4

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