Abstract
We present a new approach for quantifying the degradation of knee cartilage in the medial meniscal tear (MMT) model of osteoarthritis in the rat. A statistical strategy was used to guide the selection of a region of interest (ROI) from the images obtained from a pilot study. We hypothesize that this strategy can be used to localize a region of cartilage most vulnerable to MMT-induced damage. In order to test this hypothesis, a longitudinal study was conducted in which knee cartilage thickness in a pre-selected ROI was monitored for three weeks and comparisons were made between MMT and control rats. We observed a significant decrease in cartilage thickness in MMT rats and a significant increase in cartilage thickness in sham-operated rats as early as one week post surgery when compared to pre-surgery measurements.
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Xie, Z., Liachenko, S., Chiao, PC., Carvajal-Gonzalez, S., Bove, S., Bocan, T. (2010). In Vivo MRI Assessment of Knee Cartilage in the Medial Meniscal Tear Model of Osteoarthritis in Rats . In: Jiang, T., Navab, N., Pluim, J.P.W., Viergever, M.A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010. MICCAI 2010. Lecture Notes in Computer Science, vol 6363. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15711-0_8
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DOI: https://doi.org/10.1007/978-3-642-15711-0_8
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