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Carbon Nanotubes Filled with Carboplatin: Towards Carbon Nanotube-Supported Delivery of Chemotherapeutic Agents

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Carbon Nanotubes for Biomedical Applications

Part of the book series: Carbon Nanostructures ((CARBON))

Abstract

Thanks to their capillary-like structure CNTs provide a well-characterized container material for hosting miscellaneous fillings. Here we present basic studies on the use of CNTs for drug delivery. By introducing carboplatin, an anticancer drug, into the CNTs via a wet chemical approach, drug-filled nanotubes have been produced. The maintenance of the structure of carboplatin was proven using electron energy loss spectroscopy and X-ray photoelectron spectroscopy. It was shown that the drug is released into cell culture medium leading to cell death. Cell viability assays performed with bladder cancer cells EJ28 demonstrated the cytotoxicity of CNTs filled with carboplatin. For comparison a reference of unfilled, open ended CNTs did not affect the cell viability. These results point out the general capabilities of CNTs as nanocarriers for drug delivery.

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References

  1. Ajima, K., Yudasaka, M., Murakami, T., Maigné, A., Shiba, K., Iijima, S.: Mol. Pharm. 2, 475–480 (2005)

    Article  Google Scholar 

  2. Ajima, K., Yudasaka, M., Maigné, A., Iijima, S.: J. Phys. Chem. B 110, 19097–19099 (2006)

    Article  Google Scholar 

  3. Ajima, K., Yudasaka, M., Maigné, A., Miyawaki, J., Iijima, S.: J. Phys. Chem. B 110, 5773–5778 (2006)

    Article  Google Scholar 

  4. Balasubramanian, K., Burghard, M.: Small 1, 180–192 (2005)

    Article  Google Scholar 

  5. Chen, G., Qiu, J., Qiu, H.: Scripta Mater. 58, 457–480 (2008)

    Article  Google Scholar 

  6. Chikkannanavar, S.B., Taubert, A., Luzzi, D.E.: J. Nanosci. Nanotechnol. 3, 159–163 (2003)

    Article  Google Scholar 

  7. Ebbesen, T.W.: J. Phys. Chem. Sol. 57, 951–955 (1996)

    Article  Google Scholar 

  8. Gabriel, G., Sauthier, G., Fraxedas, J., Moreno-Mañas, M., Martínez, M.T., Miravitlles, C., Casábo, J.: Carbon 44, 1891–1897 (2006)

    Article  Google Scholar 

  9. Geng, H.Z., Zhang, X.B., Mao, S.H., Kleinhammes, A., Shimoda, H., Wu, Y., Zhou, O.: Chem. Phys. Lett. 399, 109–113 (2004)

    Article  Google Scholar 

  10. Gott, I., Gust, R.: Pharm. Unserer Zeit 2, 124–129 (2006)

    Google Scholar 

  11. Hampel, S., Leonhardt, A., Selbmann, D., Biedermann, K., Elefant, D., Mueller, C., Gemming, T., Buechner, B.: Carbon 44, 2316–2322 (2006)

    Article  Google Scholar 

  12. Hsin, Y.L., Lai, J.Y., Hwang, K.C., Lo, S.C., Chen, F.R., Kai, J.J.: Carbon 44, 3328–3335 (2006)

    Article  Google Scholar 

  13. Klumpp, C., Kostarelos, K., Prato, M., Bianco, A.: Biochim. Biophys. Acta 1758, 404–412 (2006)

    Article  Google Scholar 

  14. Kum, M.C., Joshi, K.A., Chen, W., Myung, N.V., Mulchandani. A.: Talanta. 74, 370–375 (2007)

    Article  Google Scholar 

  15. Leonhardt, A., Moench, I., Meye, A., Hampel, S., Buechner, B.: Adv. Sci. Technol. 49, 74–78 (2006)

    Article  Google Scholar 

  16. Li, J., Zhang, Y.: Appl. Surf. Sci. 252, 2944–2948 (2006)

    Article  Google Scholar 

  17. Marshall, M.W., Popa-Nita, S., Shapter, J.G.: Carbon 44, 1137–1141 (2006)

    Article  Google Scholar 

  18. Montesa, I., Muñoz, E., Benito, A.M., Maser, W.K., Martinez, M.T.: J. Nanosci. Nanotechnol. 7, 3473–3476 (2007)

    Article  Google Scholar 

  19. Pastorin, G., Wu, W., Wieckowski, S., Briand, J.P., Kostarelos, K., Prato, M., Bianco, A.: Chem. Commun. 1182–1184 (2006)

    Google Scholar 

  20. Ritschel, M., Leonhardt, A., Elefant, D., Oswald, S., Buechner, B.: J. Phys. Chem. C 111, 8414–8417 (2007)

    Article  Google Scholar 

  21. Tran, M.Q., Tridech, C., Alfrey, A., Bismarck, A., Shaffer, M.S.P.: Carbon 45, 2341–2350 (2007)

    Article  Google Scholar 

  22. Tsang, S.C., Chen, Y.K., Harris, P.J.F., Green, M.L.H.: Nature 372, 159–162 (1994)

    Article  Google Scholar 

Download references

Acknowledgments

The authors would like to thank G. Kreutzer and S. Pichl for the SEM/TEM-investigations. This work was supported by the Leibniz Association within the “Pakt für Forschung und Innovation”. Further financial support was given by the European Community through the Marie Curie Research Training Network CARBIO under contract No. MRTN-CT-2006-035616.

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Authors and Affiliations

  1. Leibniz Institute for Solid State and Materials Research (IFW), Dresden, Germany

    D. Haase, S. Hampel, A. Taylor, J. Thomas, S. Oswald, M. Ritschel, R. Klingeler, A. Leonhardt & B. Büchner

  2. Department of Urology, Dresden University of Technology (TU Dresden), Dresden, Germany

    K. Kraemer, D. Kunze, A. Taylor & M. Arlt

  3. Kirchhoff Institute for Physics, University of Heidelberg, Heidelberg, Germany

    R. Klingeler

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  1. D. Haase
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  2. S. Hampel
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  3. K. Kraemer
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  4. D. Kunze
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  5. A. Taylor
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  6. M. Arlt
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  7. J. Thomas
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  8. S. Oswald
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  9. M. Ritschel
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  10. R. Klingeler
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  11. A. Leonhardt
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  12. B. Büchner
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Corresponding author

Correspondence to D. Haase .

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Editors and Affiliations

  1. Kirchhoff Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, Heidelberg, 69120, Heidelberg, Germany

    Rüdiger Klingeler

  2. Department of Pharmacology, Oxford University, Mansfield Road, Oxford, OX1 3QU, UK

    Robert B. Sim

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Haase, D. et al. (2011). Carbon Nanotubes Filled with Carboplatin: Towards Carbon Nanotube-Supported Delivery of Chemotherapeutic Agents. In: Klingeler, R., Sim, R. (eds) Carbon Nanotubes for Biomedical Applications. Carbon Nanostructures. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14802-6_13

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