Skip to main content

An Architecture for Collaborative Translational Research Utilizing the Honest Broker System

  • Chapter
Intelligent Interactive Multimedia Systems and Services

Part of the book series: Smart Innovation, Systems and Technologies ((SIST,volume 6))

  • 575 Accesses

Abstract

Translational biomedical research involves a diverse group of researchers, data sources and data types voluminous quantities. A collaborative research application is needed to connect these diverse elements. Two approaches are used to integrate biomedical research data; a central data warehouse approach in what all the information is imported into it and a mediator approach which integrates the data on demand. We propose the Beaumont BioBank Integration Management System (BIMS), a collaborative research architecture based on the mediator approach utilizing the Honest Broker System. Our system provides collaborative, flexible and secure environment capable of accelerating biomedical research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stark, K., et al.: GATiB-CSCW, Medical Research Supported by a Service-Oriented Colla-borative System. In: Bellahsène, Z., Léonard, M. (eds.) CAiSE 2008. LNCS, vol. 5074, pp. 148–162. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  2. Boyd, A., et al.: An ’Honest Broker’ mechanism to maintain privacy for patient care and academic medical research. I. J. Medical Informatics 76(5-6), 407–411 (2007)

    Article  Google Scholar 

  3. Boyd, A., et al.: The University of Michigan Honest Broker: A Web-based Service for Clinical and Translational Research and Practice. J. Am. Med. Inform. Assoc. (16), 784–791 (2009)

    Google Scholar 

  4. Kirsten, T., et al.: An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies. In: Grust, T., Höpfner, H., Illarramendi, A., Jablonski, S., Mesiti, M., Müller, S., Patranjan, P.-L., Sattler, K.-U., Spiliopoulou, M., Wijsen, J. (eds.) EDBT 2006. LNCS, vol. 4254, pp. 399–410. Springer, Heidelberg (2006)

    Chapter  Google Scholar 

  5. caBIG, https://cabig.nci.nih.gov/ (Accessed 12-15-2009)

  6. caIntegrator2, https://cabig.nci.nih.gov/tools/caIntegrator2 (Accessed 12-9-2009)

  7. Bioconductor, http://www.bioconductor.org/ (Accessed 2-16-2010)

  8. caArray, https://cabig.nci.nih.gov/tools/caArray (Accessed 12-15-2009)

  9. caBIO, https://wiki.nci.nih.gov/display/caBIO/caBIO (Accessed 2-15-2010)

  10. caGrid, http://cagrid.org/display/cagridhome/Home (Accessed 12-11-2009)

  11. GenePattern, https://cabig.nci.nih.gov/tools/GenePattern , (Accessed 2-18-2010)

  12. NBIA, https://cabig.nci.nih.gov/tools/NCIA (Accessed 2-19-2010)

  13. caTissue, https://cabig.nci.nih.gov/tools/catissuesuite , (Accessed 12-7-2009)

  14. BIGR, http://www.healthcit.com/front/BIGR/biobanking-and-biomaterials-management (Accessed 2-15-2010)

  15. Gene Expression Omnibus, http://www.ncbi.nlm.nih.gov/geo/ (Accessed 2-18-2010)

  16. Peptidome, http://www.ncbi.nlm.nih.gov/peptidome (Accessed 2-17-2010)

  17. Velos, http://www.velos.com/products_eres_overview.shtml (Accessed 2-16-2010)

  18. NCBI Entrez, http://www.ncbi.nlm.nih.gov/sites/gquery (Accessed 2-19-2010)

  19. R, http://www.r-project.org/ (Accessed 2-17-2010)

  20. Eder, J., et al.: Data Management for Federated Biobanks. In: Bhowmick, S.S., Küng, J., Wagner, R. (eds.) Database and Expert Systems Applications. LNCS, vol. 5690, pp. 184–195. Springer, Heidelberg (2009)

    Chapter  Google Scholar 

  21. Eder, J., et al.: Information Systems for Federated Biobanks. In: T. Large-Scale Data- and Knowledge-Centered Systems I, pp. 156–190 (2009)

    Google Scholar 

  22. Bio-Rad ProteinChip SELDI, http://www.bio-rad.com/proteinchip (Accessed 3-5-2010)

  23. Nagarajan, R., et al.: Database Challenges in the Integration of Biomedical Data Sets. In: VLDB, pp. 1202–1213 (2004)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Gillies, C., Patel, N., Singh, G., Sethi, I., Akervall, J., Wilson, G. (2010). An Architecture for Collaborative Translational Research Utilizing the Honest Broker System. In: Tsihrintzis, G.A., Damiani, E., Virvou, M., Howlett, R.J., Jain, L.C. (eds) Intelligent Interactive Multimedia Systems and Services. Smart Innovation, Systems and Technologies, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14619-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-14619-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-14618-3

  • Online ISBN: 978-3-642-14619-0

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics