Abstract
Various nonsurgical regional treatments may be applicable in the treatment of children with liver tumors. Although none is currently used as part of major pediatric liver cancer trials, each has certain advantages and may be considered in selected patients. It remains to be seen whether any of these ideas become a part of standard protocols in the future.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Akinci D, Gumus B, Ozkan OS et al (2007) Percutaneous management of tumoral biliary obstruction in children. Pediatr Radiol 37:975–980
Arcement CM, Towbin RB, Meza MP et al (2000) Intrahepatic chemoembolization in unresectable pediatric liver malignancies. Pediatr Radiol 30:779–785
Arora R, Soulen MC, Haskal ZJ (1999) Cutaneous complications of hepatic chemoembolization via extrahepatic collaterals. J Vasc Interv Radiol 10:1351–1356
Bhattacharya S, Novell JR, Winslet MC et al (1994) Iodized oil in the treatment of hepatocellular carcinoma. Br J Surg 81:1563–1571
Bittles MA, Hoffer FA (2007) Interventional radiology and the care of the pediatric oncology patient. Surg Oncol 16:229–233
Boztug K, Kiely E, Roebuck DJ et al (2006) Successful treatment of MYCN amplified, progressive stage 4S neuroblastoma in a neonate with hepatic artery embolization in addition to multimodality treatment. Pediatr Blood Cancer 46:253–257
Cardinal J, de Vera ME, Marsh JW et al (2009) Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. Arch Surg 144:1035–1039
Chan KL, Tam PK (1998) Successful right trisegmentectomy for ruptured hepatoblastoma with preoperative transcatheter arterial embolization. J Pediatr Surg 33:783–786
Chen HS, Gross JF (1980) Intra-arterial infusion of anticancer drugs: theoretic aspects of drug delivery and review of responses. Cancer Treat Rep 64:31–40
Czauderna P, Zbrzezniak G, Narozanski W et al (2005) Pulmonary embolism: a fatal complication of arterial chemoembolization for advanced hepatocellular carcinoma. J Pediatr Surg 40:1647–1650
Czauderna P, Zbrzezniak G, Narozanski W et al (2006) Preliminary experience with arterial chemoembolization for hepatoblastoma and hepatocellular carcinoma in children. Pediatr Blood Cancer 46:825–828
de Graaf W, van den Esschert JW, van Lienden KP et al (2009) Induction of tumor growth after preoperative portal vein embolization: is it a real problem? Ann Surg Oncol 16:423–430
Dimashkieh HH, Mo JQ, Wyatt-Ashmead J et al (2004) Pediatric hepatic angiosarcoma: case report and review of the literature. Pediatr Dev Pathol 7:527–532
Draper H, Diamond IR, Temple M et al (2008) Multimodal management of endangering hepatic hemangioma: impact on transplant avoidance: a descriptive case series. J Pediatr Surg 43:120–125, discussion 126
Ensminger WD, Gyves JW (1984) Regional cancer chemotherapy. Cancer Treat Rep 68:101–115
Geschwind JFH, Ramsey DE, Cleffken B et al (2003) Transcatheter arterial chemoembolization of liver tumors: effects of chemoembolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovasc Intervent Radiol 26:111–117
Golladay ES, Mollitt DL, Osteen PK et al (1985) Conversion to resectability by intra-arterial infusion chemotherapy after failure of systemic chemotherapy. J Pediatr Surg 20:715–717
Goncalves de Oliveira-Filho A, Lopes Miranda M, Leonelli Diz F et al (2003) Use of radiofrequency for ablation of unresectable hepatic metastasis in desmoplastic small round cell tumor. Med Pediatr Oncol 41:476–477
Han YM, Park HH, Lee JM et al (1999) Effectiveness of preoperative transarterial chemoembolization in presumed inoperable hepatoblastoma. J Vasc Interv Radiol 10:1275–1280
Heran MK, Marshalleck F, Temple M et al (2010) Joint quality improvement guidelines for pediatric arterial access and arteriography: from the Societies of Interventional Radiology and Pediatric Radiology. Pediatr Radiol 40:237–250
Hoffer FA (2000) Liver biopsy methods for pediatric oncology patients. Pediatr Radiol 30:481–488
Hoffer FA, Daw NC, Xiong X et al (2009) A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 115:1328–1337
Iannitti DA, Dupuy DE, Mayo-Smith WW et al (2002) Hepatic radiofrequency ablation. Arch Surg 137:422–426, discussion 427
Iida T, Suenaga M, Takeuchi Y et al (2004) Successful resection of a ruptured hepatoblastoma prior to chemotherapy: report of a case. Surg Today 34:710–714
Jiang XW, Li JH, Hu XL et al (2006) Combined treatment of hepatoblastoma with transcatheter arterial chemoembolization and surgery. Pediatr Hematol Oncol 23:1–9
Kassarjian A, Zurakowski D, Dubois J et al (2004) Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol 182:785–795
Kaye R, Sane SS, Towbin RB (2000) Pediatric intervention: an update – part II. J Vasc Interv Radiol 11:807–822
Lau WY, Leung TW, Ho S et al (1994) Diagnostic pharmaco-scintigraphy with hepatic intra-arterial technetium-99m macroaggregated albumin in the determination of tumour to non-tumour uptake ratio in hepatocellular carcinoma. Br J Radiol 67:136–139
Lau WY, Ho S, Leung TW et al (1998) Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90yttrium microspheres. Int J Radiat Oncol Biol Phys 40:583–592
Lau WY, Ho SK, Yu SC et al (2004) Salvage surgery following downstaging of unresectable hepatocellular carcinoma. Ann Surg 240:299–305
Leung WT, Lau WY, Ho SK et al (1994) Measuring lung shunting in hepatocellular carcinoma with intrahepatic-arterial technetium-99m macroaggregated albumin. J Nucl Med 35:70–73
Leung TW, Lau WY, Ho SK et al (1995) Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–924
Li JP, Chu JP, Yang JY et al (2008) Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children. Cardiovasc Intervent Radiol 31:1117–1123
Liu H, Zhu S (2009) Present status and future perspectives of preoperative portal vein embolization. Am J Surg 197:686–690
Malogolowkin MH, Stanley P, Steele DA et al (2000) Feasibility and toxicity of chemoembolization for children with liver tumors. J Clin Oncol 18:1279–1284
Nakagawa N, Cornelius AS, Kao SC et al (1993) Transcatheter oily chemoembolization for unresectable malignant liver tumors in children. J Vasc Interv Radiol 4:353–358
O’Hagan AH, Irvine AD, Sands A et al (2004) Miliary neonatal hemangiomatosis with fulminant heart failure and cardiac septal hypertrophy in two infants. Pediatr Dermatol 21:469–472
Ogita S, Tokiwa K, Taniguchi H et al (1987) Intraarterial chemotherapy with lipid contrast medium for hepatic malignancies in infants. Cancer 60:2886–2890
Ohtsuka Y, Matsunaga T, Yoshida H et al (2004) Optimal strategy of preoperative transcatheter arterial chemoembolization for hepatoblastoma. Surg Today 34:127–133
Oue T, Fukuzawa M, Kusafuka T et al (1998) Transcatheter arterial chemoembolization in the treatment of hepatoblastoma. J Pediatr Surg 33:1771–1775
Pentecost MJ, Daniels JR, Teitelbaum GP et al (1993) Hepatic chemoembolization: safety with portal vein thrombosis. J Vasc Interv Radiol 4:347–351
Raoul JL, Heresbach D, Bretagne JF et al (1992) ChemoemboÂlization of hepatocellular carcinomas. A study of the biodistribution and pharmacokinetics of doxorubicin. Cancer 70:585–590
Roebuck DJ (2010) Gastrointestinal intervention in children. Pediatr Radiol (in press)
Roebuck DJ, Stanley P (2000) External and internal-external biliary drainage in children with malignant obstructive jaundice. Pediatr Radiol 30:659–664
Schindera ST, Nelson RC, DeLong DM et al (2006) Intrahepatic tumor recurrence after partial hepatectomy: value of percutaneous radiofrequency ablation. J Vasc Interv Radiol 17:1631–1637
Shibata J, Fujiyama S, Sato T et al (1989) Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma. Cancer 64:1586–1594
Soini Y, Virkajarvi N, Raunio H et al (1996) Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis. J Clin Pathol 49:470–473
Sue K, Ikeda K, Nakagawara A et al (1989) Intrahepatic arterial injections of cisplatin-phosphatidylcholine-Lipiodol suspension in two unresectable hepatoblastoma cases. Med Pediatr Oncol 17:496–500
Tashjian DB, Moriarty KP, Courtney RA et al (2002) Preoperative chemoembolization for unresectable hepatoblastoma. Pediatr Surg Int 18:187–189
Truant S, Oberlin O, Sergent G et al (2007) Remnant liver volume to body weight ratio > or =0.5%: A new cut-off to estimate postoperative risks after extended resection in noncirrhotic liver. J Am Coll Surg 204:22–33
Ueno S, Hirakawa H, Yokoyama S et al (2005) Treatment of infantile hepatoblastoma and related complications. Tokai J Exp Clin Med 30:203–209
van Gulik TM, van den Esschert JW, de Graaf W et al (2008) Controversies in the use of portal vein embolization. Dig Surg 25:436–444
Von Schweinitz D, Faundez A, Teichmann B et al (2000) Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma. Int J Cancer 85:151–159
Weintraub M, Bloom AI, Gross E et al (2004) Successful treatment of progressive stage 4s hepatic neuroblastoma in a neonate with intra-arterial chemoembolization. Pediatr Blood Cancer 43:148–151
Ye J, Shu Q, Li M et al (2008) Percutaneous radiofrequency ablation for treatment of hepatoblastoma recurrence. Pediatr Radiol 38:1021–1023
Zenzen W, Perez-Atayde AR, Elisofon SA et al (2009) Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. Pediatr Radiol 39:1118–1123
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Berlin Heidelberg
About this chapter
Cite this chapter
Roebuck, D.J. (2011). Alternative Approaches for Treatment. In: Zimmermann, A., Perilongo, G. (eds) Pediatric Liver Tumors. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14504-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-14504-9_14
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-14503-2
Online ISBN: 978-3-642-14504-9
eBook Packages: MedicineMedicine (R0)