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Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production

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Biosurfactants

Part of the book series: Microbiology Monographs ((MICROMONO,volume 20))

Abstract

As promising biotechnological products, rhamnolipids (RLs) are the most investigated biosurfactants. Over the years, important efforts have been spent and an array of techniques has been developed for the isolation of producing bacterial strains and the characterization of a large variety of RL homologs and congeners. Investigations on RL production by the best known producer, the opportunistic pathogen Pseudomonas aeruginosa, have shown that production of RLs proceeds through de novo biosynthesis of precursors. Over the last 15 years, the genetic details underlying RL production in P. aeruginosa have been mostly unraveled, revealing a complex regulatory mechanism controlled by quorum sensing pathways of intercellular communication. A number of nutritional and cultivation factors affecting RL productivity have also been identified, while the use of many affordable and renewable raw substrates has been described to optimize the production. Multidisciplinary approaches are increasingly adopted to develop methods for the safe, cost-effective, and highly efficient production of RLs at the industrial scale.

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Authors and Affiliations

  1. INRS-Institut Armand Frappier, Laval, QC, Canada, H7V 1B7

    Ahmad Mohammad Abdel-Mawgoud, Francois Lépine & Eric Déziel

  2. Institute of Engineering in Life Sciences, Section of Technical Biology, Research University Karlsruhe, Engler-Bunte-Ring 1, 76131, Karlsruhe, Germany

    Rudolf Hausmann & Markus M. Müller

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  1. Ahmad Mohammad Abdel-Mawgoud
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  2. Rudolf Hausmann
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  3. Francois Lépine
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  4. Markus M. Müller
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  5. Eric Déziel
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Editors and Affiliations

  1. Inst. Biotecnología, Dept. Microbiologia Molecular/, UNAM, Cuernavaca, MOR., Mexico

    Gloria Soberón-Chávez

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Abdel-Mawgoud, A.M., Hausmann, R., Lépine, F., Müller, M.M., Déziel, E. (2011). Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production. In: Soberón-Chávez, G. (eds) Biosurfactants. Microbiology Monographs, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14490-5_2

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