Skip to main content
SpringerLink
Log in

Cellular Partners in the Embryonic Induction of Lymphoid Territories: Origins and Transcriptional Regulation

  • Chapter
  • First Online:
Developmental Biology of Peripheral Lymphoid Organs

  • 492 Accesses

Abstract

A milestone in our understanding the essential steps of lymphoid organogenesis was the identification and characterization of those cell partners that are considered today as the founder pairs launching the process. This chapter summarizes the discovery and general biological features of these cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adachi S, Yoshida H, Kataoka H, Nishikawa S (1997) Three distinctive steps in Peyer’s patch formation of murine embryo. Int Immunol 9:507–514

    Article  PubMed  CAS  Google Scholar 

  • Cupedo T, Vondenhoff MF, Heeregrave EJ, De Weerd AE, Jansen W, Jackson DG, Kraal G, Mebius RE (2004a) Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes. J Immunol 173:2968–2975

    PubMed  CAS  Google Scholar 

  • Cupedo T, Jansen W, Kraal G, Mebius RE (2004b) Induction of secondary and tertiary lymphoid structures in the skin. Immunity 21:655–667

    Article  PubMed  CAS  Google Scholar 

  • Doisne JM, Becourt C, Amniai L, Duarte N, Le Luduec JB, Eberl G, Benlagha K (2009) Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions. J Immunol 183:2142–2149

    Article  PubMed  CAS  Google Scholar 

  • Eberl G, Littman DR (2003) The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer’s patches. Immunol Rev 195:81–90

    Article  PubMed  CAS  Google Scholar 

  • Eberl G, Littman DR. (2004) Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305:248–251

    Article  PubMed  CAS  Google Scholar 

  • Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y, Littman DR (2004) An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 5:64–73

    Article  PubMed  CAS  Google Scholar 

  • Finke D, Acha-Orbea H, Mattis A, Lipp M, Kraehenbuhl J (2002) CD4+CD3− cells induce Peyer’s patch development: role of alpha4beta1 integrin activation by CXCR5. Immunity 17:363–373

    Article  PubMed  CAS  Google Scholar 

  • Fütterer A, Mink K, Luz A, Kosco-Vilbois MH, Pfeffer K (1998) The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59–70

    Article  PubMed  Google Scholar 

  • Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, Sharpe A (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143–156

    Article  PubMed  CAS  Google Scholar 

  • Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y, Zenke M (2003) Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 4:380–386

    Article  PubMed  CAS  Google Scholar 

  • Ji M, Li H, Suh HC, Klarmann KD, Yokota Y, Keller JR (2008) Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins. Blood 112:1068–1077

    Article  PubMed  CAS  Google Scholar 

  • Kapasi ZF, Burton GF, Shultz LD, Tew JG, Szakal AK (1993) Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells. J Immunol 150:2648–2658

    PubMed  CAS  Google Scholar 

  • Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A (2008) Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol 181:6189–6200

    PubMed  CAS  Google Scholar 

  • Kelly KA, Scollay R (1992) Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3−CD4+ cells. Eur J Immunol 22:329–334

    Article  PubMed  CAS  Google Scholar 

  • Krishan K, McKinnell I, Patel K, Dhoot GK (2005) Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome. Dev Dyn 234:363–370

    Article  PubMed  CAS  Google Scholar 

  • Lampisuo M, Liippo J, Vainio O, McNagny KM, Kulmala J, Lassila O (1999) Characterization of prethymic progenitors within the chicken embryo. Int Immunol 11:63–69

    Article  PubMed  CAS  Google Scholar 

  • Mebius RE, Streeter PR, Michie S, Butcher EC, Weissman IL (1996) A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3− cells to colonize lymph nodes. Proc Natl Acad Sci USA 93:11019–11024

    Article  PubMed  CAS  Google Scholar 

  • Mebius RE, Rennert P, Weissman IL (1997) Developing lymph nodes collect CD4+CD3− LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7:493–504

    Article  PubMed  CAS  Google Scholar 

  • Mebius RE, Miyamoto T, Christensen J, Domen J, Cupedo T, Weissman IL, Akashi K (2001) The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3− cells, as well as macrophages. J Immunol 166:6593–6601

    PubMed  CAS  Google Scholar 

  • Michel ML, Mendes-da-Cruz D, Keller AC, Lochner M, Schneider E, Dy M, Eberl G, Leite-de-Moraes MC (2008) Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci USA 105:19845–19850

    Article  PubMed  Google Scholar 

  • Nishikawa S, Honda K, Vieira P, Yoshida H. (2003) Organogenesis of peripheral lymphoid organs. Immunol Rev 195:72–80

    Article  PubMed  CAS  Google Scholar 

  • Okuda M, Togawa A, Wada H, Nishikawa S. (2007) Distinct activities of stromal cells involved in the organogenesis of lymph nodes and Peyer’s patches. J Immunol 179:804–811

    PubMed  CAS  Google Scholar 

  • Ruddle NH, Akirav EM (2009) Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response. J Immunol 183:2205–2212

    Article  PubMed  CAS  Google Scholar 

  • Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR (2000) Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 288:2369–2373

    Article  PubMed  CAS  Google Scholar 

  • Tumanov AV, Grivennikov SI, Shakhov AN, Rybtsov SA, Koroleva EP, Takeda J, Nedospasov SA, Kuprash DV (2003) Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev 195:106–116

    Article  PubMed  CAS  Google Scholar 

  • Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K (1996) Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5:537–549

    Article  PubMed  CAS  Google Scholar 

  • Yokota Y, Mansouri A, Mori S, Sugawara S, Adachi S, Nishikawa S, Gruss P (1999) Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397:702–706

    Article  PubMed  CAS  Google Scholar 

  • Yoshida H, Honda K, Shinkura R, Adachi S, Nishikawa S, Maki K, Ikuta K, Nishikawa SI (1999) IL-7 receptor alpha+ CD3(−) cells in the embryonic intestine induces the organizing center of Peyer’s patches. Int Immunol 11:643–655

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology and Biotechnology, Faculty of Medicine, University of Pécs, Pécs, Hungary

    Péter Balogh

Authors
  1. Péter Balogh
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. , Department of Immunology and Biotechnolo, University of Pecs, Szigeti út 12, Pecs, 7624, Hungary

    Peter Balogh

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Balogh, P. (2011). Cellular Partners in the Embryonic Induction of Lymphoid Territories: Origins and Transcriptional Regulation. In: Balogh, P. (eds) Developmental Biology of Peripheral Lymphoid Organs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14429-5_2

Download citation

Publish with us

Policies and ethics

Search

Navigation