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Formation and Function of White Pulp Lymphocyte Rich Areas of Spleen

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Developmental Biology of Peripheral Lymphoid Organs

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Abstract

The spleen is two organs in one: the red pulp where fixed tissue macrophages remove effete red blood cells and pathogens, and the white pulp areas within which adaptive lymphocyte-dependent immune responses evolve and are maintained. In this section, we review the signals and cells that regulate the development of the white pulp areas, and how this enables the development and maintenance of immune responses. We particularly emphasize the role of lymphoid tissue inducer cells in establishing and maintaining immune responses in the spleen.

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Acknowledgments

This work was supported by a Wellcome Trust Programme Grant to PL.

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Authors and Affiliations

  1. MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK

    Peter J. L. Lane, Fiona M McConnell & David Withers

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  1. Peter J. L. Lane
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  2. Fiona M McConnell
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Correspondence to Peter J. L. Lane .

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  1. , Department of Immunology and Biotechnolo, University of Pecs, Szigeti út 12, Pecs, 7624, Hungary

    Peter Balogh

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Lane, P.J.L., McConnell, F.M., Withers, D. (2011). Formation and Function of White Pulp Lymphocyte Rich Areas of Spleen. In: Balogh, P. (eds) Developmental Biology of Peripheral Lymphoid Organs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14429-5_12

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