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Structural Evolution of the Spleen in Man and Mouse

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Book cover Developmental Biology of Peripheral Lymphoid Organs

Abstract

Of all the peripheral lymphoid tissues, spleen represents the earliest organ specialized to perform adaptive immune responses, and it has also preserved its basic structural organization in various vertebrate classes. Its architecture, as well as developmental properties, is strikingly different from other secondary lymphoid organs. Here we summarize the developmental regulation of its main tissue compartments in man and mouse during the prenatal and early postnatal period, with particular emphasis on its nonhemopoietic stromal constituents and their macrodomains.

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Acknowledgment

This work was supported by the University of Pécs Faculty of Medicine Research Grant to Péter Balogh.

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  1. Department of Immunology and Biotechnology, Faculty of Medicine, University of Pécs, Pécs, Hungary

    Péter Balogh & Árpád Lábadi

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Correspondence to Péter Balogh .

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  1. , Department of Immunology and Biotechnolo, University of Pecs, Szigeti út 12, Pecs, 7624, Hungary

    Peter Balogh

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Balogh, P., Lábadi, Á. (2011). Structural Evolution of the Spleen in Man and Mouse. In: Balogh, P. (eds) Developmental Biology of Peripheral Lymphoid Organs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14429-5_11

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