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Pharmacogenetic and Pharmacogenomic Considerations in the Biology and Treatment of Childhood Leukemia

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Childhood Leukemia

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Pharmacogenetics and pharmacogenomics refer to the study of the genetic basis for variation in drug response. Pharmacogenomics agnostically surveys the entire genome for genetic factors affecting response to medication, while pharmacogenetics primarily focuses on a handful of genomic loci based on prior knowledge. Still rapidly evolving, pharmacogenetics and pharmacogenomics have already significantly changed many fields of medicine. Thus, genetic variation has been implicated in drug efficacy (e.g., CYP2D6 and tamoxifen in breast cancer [Hoskins et al. 2009], CYP2C19 and clopidogrel in platelet aggregation [Shuldiner et al. 2009; Simon et al. 2009]), and toxicity (e.g., TPMT and 6-mercaptopurine-related myelosuppression (Relling et al. 1999b), CYP2C9 and warfarin-induced bleeding (International Warfarin Pharmacogenetics et al. 2009), HLA-B*5701 and flucloxacillin-induced liver damage (Daly et al. 2009).

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Authors and Affiliations

  1. St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA

    Jun J. Yang

  2. Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, 45229-3039, USA

    Parinda A. Mehta

  3. Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, MS 313, Memphis, TN, 38105-3678, USA

    Mary V. Relling

  4. Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, CHRF-2323, Cincinnati, OH, 45229, USA

    Stella M. Davies

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    Gregory H. Reaman

  2. Cincinnati Children's Hospital, Medical Center (CCHMC), University of Cincinnati, Burnett Avenue 3333, Cincinnati, 45229, Ohio, USA

    Franklin O. Smith

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Yang, J.J., Mehta, P.A., Relling, M.V., Davies, S.M. (2011). Pharmacogenetic and Pharmacogenomic Considerations in the Biology and Treatment of Childhood Leukemia. In: Reaman, G., Smith, F. (eds) Childhood Leukemia. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13781-5_6

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