Skip to main content
SpringerLink
Log in
Book cover

Medicinal Organometallic Chemistry pp 247–285Cite as

Carbon Monoxide: An Essential Signalling Molecule

  • Chapter
  • First Online:

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 32))

Abstract

Carbon monoxide (CO), like nitric oxide (NO), is an essential signalling molecule in humans. It is active in the cardiovascular system as a vasodilator. In addition, CO possesses anti-inflammatory, anti-apoptotic and anti-proliferative properties and protects tissues from hypoxia and reperfusion injury. Some of its applications in animal models include suppression of organ graft rejection and safeguarding the heart during reperfusion after cardiopulmonary bypass surgery. CO also suppresses arteriosclerotic lesions following angioplasty, reverses established pulmonary hypertension and mitigates the development of post-operative ileus in the murine small intestine and the development of cerebral malaria in mice as well as graft-induced intimal hyperplasia in pigs. There have been several clinical trials using air–CO mixtures for the treatment of lung-, heart-, kidney- and abdominal-related diseases. This review examines the research involving the development of classes of compounds (with particular emphasis on metal carbonyls) that release CO, which could be used in clinically relevant conditions. The review is drawn not only from published papers in the chemical literature but also from the extensive biological literature and patents on CO-releasing molecules (CO-RMs).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

AEGL3:

Acute exposure guideline level 3 – life-threatening health effects or death

AMP:

Adenosine monophosphate

ANG:

Angiotensin

ASMC:

Airway smooth muscle cells

BAY:

41-2272 5-cyclopropyl-2[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b] pyridine-3-yl] pyrimidin-4-ylamine

cGC:

Guanylyl cyclase

cGMP:

5′-cyclic guanylyl phosphate

CORM-1:

[Mn2(CO)10]

CORM-2:

[RuCl2(CO)3]2

CORM-3:

[RuCl(glycinate)(CO)3]

CORM-A1:

Na[H3BCO2H]

CO-RMs:

CO-releasing molecules

COX-2:

Cyclooxygenase-2

DC:

Dendritic cell

DMSO:

Dimethylsulfoxide

EC:

Endothelial cells

ERK1/2:

Extracellular signal-regulated kinase-1 and -2

ICAM-1:

Intercellular adhesion molecule-1

IL:

Interleukin

iNOS:

Inducible NO synthase

LPS:

Lipopolysaccharide

Mb:

Myoglobin

MbCO:

Carboxymyoglobin

MMP:

Matrix metalloproteinase

mRNA:

messenger Ribonucleic acid

mTALH:

Medullary thick ascending limb

NAD(P)H:

Nicotinamide adenine dinucleotide phosphate

NANC:

Non-adrenergic/non-cholinergic

NF-κB:

Eukaryotic transcription factor

Nox4:

Gene that encodes the enzyme NADPH oxidase 4

PC-12:

A cancer cell line

PMN:

Human neutrophils

PPAR-gamma:

Peroxisome proliferator-activated receptor-gamma

PTEN:

Phosphatase and tensin homolog

ROS:

Reactive oxygen species

sFlt-1:

Soluble fms-like tyrosine kinase-1

STZ:

Streptozotocin

THF:

Tetrahydrofuran

TLR:

Toll-like receptors

TNF-α:

Tumour necrosis factor-alpha

VEGFR-2:

Vascular endothelial growth factor-2

YC-1:

1-benzyl-3-(5′-hydroxymethyl-2-furyl)indazole

References

  1. Vreman HJ, Wong RJ, Stevenson DK (2002) Carbon monoxide and cardiovascular functions. CRC Press, Boca Raton, p 273

    Google Scholar 

  2. Marks GS, Brien JF, Nakatsu K, McLaughlin BE (1991) Trends Pharmacol Sci 12:185

    CAS  Google Scholar 

  3. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN (1987) Science 235:1043

    Google Scholar 

  4. McDonagh AF (1990) Clin Perinatol 17:359

    CAS  Google Scholar 

  5. Zayasu K, Sekizawa K, Okinaga S, Yamaya M, Ohrui T, Sasaki H (1997) Am J Respir Crit Care Med 156:1140

    CAS  Google Scholar 

  6. Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ (1998) Thorax 53:668

    CAS  Google Scholar 

  7. Horvath I, Loukides S, Wodehouse T, Kharitonov SA, Cole PJ, Barnes PJ (1998) Thorax 53:867

    CAS  Google Scholar 

  8. Antuni JD, Kharitonov SA, Hughes D, Hodson ME, Barnes PJ (2000) Thorax 55:138

    CAS  Google Scholar 

  9. Paredi P, Kharitonov SA, Leak D, Shah PL, Cramer D, Hodson ME, Barnes PJ (2000) Am J Respir Crit Care Med 161:1247

    CAS  Google Scholar 

  10. Paredi P, Biernacki W, Invernizzi G, Kharitonov SA, Barnes PJ (1999) Chest 116:1007

    CAS  Google Scholar 

  11. Monma M, Yamaya M, Sekizawa K, Ikeda K, Suzuki N, Kikuchi T, Takasaka T, Sasaki H (1999) Clin Exp Allergy 29:1537

    CAS  Google Scholar 

  12. Abraham NG, Kappas A (2008) Pharm Rev 60:79

    CAS  Google Scholar 

  13. Mann BE, Motterlini R (2007) Chem Commun 4197

    Google Scholar 

  14. Foresti R, Bani-Hani MG, Motterlini R (2008) Int Care Med 34:649

    CAS  Google Scholar 

  15. Alberto R, Motterlini R (2007) Dalton Trans 1651

    Google Scholar 

  16. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP (2001) J Immunol 166:4185

    CAS  Google Scholar 

  17. Lavitrano M, Smolenski RT, Musumeci A, Maccherini M, Slominska E, di Florio E, Bracco A, Mancini A, Stassi G, Patti M, Giovannoni R, Froio A, Simeone F, Forni M, Bacci ML, D’Alise G, Cozzi E, Otterbein LE, Yacoub MH, Bach FH, Calise F (2004) Faseb J 18:U709

    Google Scholar 

  18. Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song RP, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AMK, Soares MP (2003) Nat Med 9:183

    CAS  Google Scholar 

  19. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE (2006) J Exp Med 203:2109

    CAS  Google Scholar 

  20. Moore BA, Otterbein LE, Turler A, Choi AMK, Bauer AJ (2003) Gastroenterology 124:377

    CAS  Google Scholar 

  21. Pamplona A, Ferreira A, Balla J, Jeney V, Balla G, Epiphanio S, Chora ÂA, Rodrigues CD, Gregoire IP, Cunha-Rodrigues M, Portugal S, Soares MP, Mota MM (2007) Nat Med 13:703

    CAS  Google Scholar 

  22. Ramlawi B, Scott JR, Feng J, Mieno S, Raman KG, Gallo D, Csizmadia E, Chin BY, Bach FH, Otterbein LE, Sellke FW (2007) J Surg Res 138:121

    CAS  Google Scholar 

  23. Mayr FB, Spiel A, Leitner J, Marsik C, Germann P, Ullrich R, Wagner O, Jilma B (2005) Am J Respir Crit Care Med 171:354

    Google Scholar 

  24. Bathoorn E, Slebos DJ, Postma DS, Koeter GH, van Oosterhout AJM, van der Toorn M, Boezen HM, Kerstjens HAM (2007) Eur Respir J 30:1131

    CAS  Google Scholar 

  25. Carbon Monoxide to Prevent Lung Inflammation http://www.clinicaltrials.gov/ct2/show/NCT00094406. Accessed 21 Feb 2010

  26. Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients http://www.clinicaltrials.gov/ct2/show/NCT00531856. Accessed 16 Feb 2010

  27. Effects of Heme Arginate in Healthy Male Subjects http://www.clinicaltrials.gov/ct2/show/NCT00682370. Accessed 7 Jan 2009

  28. Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction? http://www.clinicaltrials.gov/ct2/show/NCT00483587. Accessed 21 Feb 2010

  29. Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery http://www.clinicaltrials.gov/ct2/show/NCT01050712. Accessed 16 Feb 2010

  30. Mims MP, Porras AG, Olson JS, Noble RW, Peterson JA (1983) J Biol Chem 258:14219

    CAS  Google Scholar 

  31. Alonso J-R, Cardellach F, Lopez S, Casademont J, Miro O (2003) Pharmacol Toxicol 93:142

    CAS  Google Scholar 

  32. Zuckerbraun BS, Chin BY, Bilban M, de Costa d’Avila J, Rao J, Billiar TR, Otterbein LE (2007) FASEB J 21:1099

    CAS  Google Scholar 

  33. Borisov VB (2008) Biochemistry (Moscow) 73:14

    CAS  Google Scholar 

  34. Abu-Soud HM, Wu C, Ghosh DK, Stuehr DJ (1998) Biochemistry 37:3777

    CAS  Google Scholar 

  35. Martin E, Berka V, Bogatenkova E, Murad F, Tsai AL (2006) J Biol Chem 281:27836

    CAS  Google Scholar 

  36. Goldbaum LR, Ramirez RG, Absolam KB (1975) Aviat Space Environ Med 1289

    Google Scholar 

  37. Noble RW, Gibson QH, Brunori M, Antonini E, Wyman J (1969) J Biol Chem 244:3905

    CAS  Google Scholar 

  38. O’Brien HR, Parker WL (1922) J Biol Chem 50:289

    Google Scholar 

  39. Ma XL, Sayed N, Beuve A, van den Akker F (2007) EMBO J 26:578

    CAS  Google Scholar 

  40. Friebe A, Schultz G, Koesling D (1996) EMBO J 15:6863

    CAS  Google Scholar 

  41. Martin E, Sharina I, Kots A, Murad F (2003) Proc Natl Acad Sci USA 100:9208

    CAS  Google Scholar 

  42. Martin E, Czarnecki K, Jayaraman V, Murad F, Kincaid J (2005) J Am Chem Soc 127:4625

    CAS  Google Scholar 

  43. Bloch KD, Ichinose F, Zapol WM, Evgenov OV (2005) Enhancing the effectiveness of an inhaled therapeutic gas. Patent WO 2005/077005

    Google Scholar 

  44. Williams SEJ, Wootton P, Mason HS, Bould J, Iles DE, Riccardi D, Peers C, Kemp PJ (2004) Science 306:2093

    CAS  Google Scholar 

  45. Williams SE, Brazier SP, Baban N, Telezhkin V, Muller CT, Riccardi D, Kemp PJ (2008) Pflugers Arch 456:561

    CAS  Google Scholar 

  46. Wang S, Publicover S, Gu Y (2009) Proc Natl Acad Sci 106:2957

    CAS  Google Scholar 

  47. Brazier SP, Telezhkin V, Mears R, Muller CT, Riccardi D, Kemp PJ (2009) Adv Exp Med Biol 648:49

    CAS  Google Scholar 

  48. Shititani T, Iwabuchi T, Soga T, Kato Y, Yamamoto T, Takano N, Hishiki T, Ueno Y, Ikeda S, Sakuragawa T, Ishikawa K, Goda N, Kitagawa Y, Kajjimura M, Matsumoto K, Suematsu M (2009) Hepatology 49:141

    Google Scholar 

  49. Schubert MP (1933) J Am Chem Soc 55:4563

    CAS  Google Scholar 

  50. Ferrier F, Terzian G, Mossoyan J, Benlian D (1995) J Mol Struct 344:189

    CAS  Google Scholar 

  51. Oppenheimer NJ, Rodriguez LO, Hecht SM (1979) Proc Natl Acad Sci 76:5616

    CAS  Google Scholar 

  52. Sugiura Y, Kuwahara J, Suzuki T (1985) FEBS Lett 182:39

    CAS  Google Scholar 

  53. Ragsdale SW (2006) Chem Rev 106:3317

    CAS  Google Scholar 

  54. Bayston JH, Winfield ME (1967) J Catal 9:217

    CAS  Google Scholar 

  55. Lee L-P, Schrauzer GN (1968) J Am Chem Soc 90:5274

    CAS  Google Scholar 

  56. Schrauzer GN, Lee L-P (1970) Arch Biochem Biophys 138:16

    CAS  Google Scholar 

  57. Friedrich W (1970) Z Naturforsch B 25:1431

    CAS  Google Scholar 

  58. Motterlini RA, Mann BE (2002) Preparation of metal complexes for therapeutic delivery of carbon monoxide as vasodilator. Patent WO 2002/092075

    Google Scholar 

  59. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ (2002) Circ Res 90:E17

    CAS  Google Scholar 

  60. Alessio E, Milani B, Bolle M, Mestroni G, Faleschini P, Todone F, Geremia S, Calligaris M (1995) Inorg Chem 34:4722

    CAS  Google Scholar 

  61. Obirai JC, Hamadi S, Ithurbide A, Wartelle C, Nyokong T, Zagal J, Top S, Bedioui F (2006) Electroanalysis 18:1689

    CAS  Google Scholar 

  62. Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ, Motterlini R (2005) Br J Pharmacol 145:800

    CAS  Google Scholar 

  63. Kwak HJ, Song JS, No ZS, Song JH, Yang SD, Cheon HG (2005) Inflamm Res 54:508

    CAS  Google Scholar 

  64. Srisook K, Han SS, Choi HS, Li MH, Ueda H, Kim C, Cha YN (2006) Biochem Pharmacol 71:307

    CAS  Google Scholar 

  65. Tsoyi K, Ha Y-M, Kim Y-M, Lee Y-S, Kim H-J, Kim H-J, Seo H-G, Lee J-H, Chang K-C (2009) Inflammation 32:364

    CAS  Google Scholar 

  66. Yang NC, Lu LH, Kao YH, Chau LY (2004) J Biomed Sci 11:799

    CAS  Google Scholar 

  67. Li MH, Jang JH, Na HK, Cha YN, Surh YJ (2007) J Biol Chem 282:28577

    CAS  Google Scholar 

  68. Li MH, Cha YN, Surh YJ (2006) Biochem Biophys Res Commun 342:984

    CAS  Google Scholar 

  69. Botros FT, Navar LG (2006) Am J Physiol 291:H2772

    CAS  Google Scholar 

  70. De Backer O, Lefebvre RA (2007) Eur J Pharmacol 572:197

    Google Scholar 

  71. De Backer O, Elinck E, Sips P, Buys E, Brouckaert P, Lefebvre RA (2008) Naunyn-Schmiedeberg’s Arch Pharmacol 378:493

    Google Scholar 

  72. Rattan S, Haj RA, De Godoy MAF (2004) Am J Physiol Gastroint Liver Physiol 287:G605

    CAS  Google Scholar 

  73. Stanford SJ, Walters MJ, Hislop AA, Haworth SG, Evans TW, Mann BE, Motterlini R, Mitchell JA (2003) Eur J Pharmacol 473:135

    CAS  Google Scholar 

  74. Taille C, El-Benna J, Lanone S, Boczkowski J, Motterlini R (2005) J Biol Chem 280:25350

    CAS  Google Scholar 

  75. Cudmore M, Ahmad S, Al-Ani B, Fujisawa T, Coxall H, Chudasama K, Devey LR, Wigmore SJ, Abbas A, Hewett PW, Ahmed A (2007) Circulation 115:1789

    CAS  Google Scholar 

  76. Kooli A, Kermorvant-Duchemin E, Sennlaub F, Bossolasco M, Hou X, Honore JC, Dennery PA, Sapieha P, Varma D, Lachapelle P, Zhu T, Tremblay S, Hardy P, Jain K, Balazy M, Chemtob S (2008) Free Rad Biol Méd 44:815

    CAS  Google Scholar 

  77. Choi HC, Kim HS, Lee KY, Chang KC, Kang YJ (2008) Biochem Biophys Res Commun 376:753

    CAS  Google Scholar 

  78. Hasan RN, Schafer AI (2008) Circ Res 102:42

    CAS  Google Scholar 

  79. Megias J, Busserolles J, Alcaraz MJ (2007) Br J Pharmacol 150:977

    CAS  Google Scholar 

  80. Sun B, Sun H, Liu C, Shen J, Chen Z, Chen X (2007) J Surg Res 139:128

    CAS  Google Scholar 

  81. Sun B-W, Chen X, Chen Z-Y, Katada K, Cepinskas G (2007) Zhonghua Yi Xue Za Zhi 87:3148

    CAS  Google Scholar 

  82. Sun B-W, Chen X, Chen Z-Y, Kazuhiro K, Gediminas C (2007) Zhonghua Shao Shang Za Zhi 23:179

    CAS  Google Scholar 

  83. Cepinskas G, Katada K, Bihari A, Potter RF (2008) Am J Physiol Gastrointest Liver Physiol 294:G184

    CAS  Google Scholar 

  84. Van Landeghem L, Laleman W, Vander Elst I, Zeegers M, van Pelt J, Cassiman D, Nevens F (2009) Liver Int 29:650

    Google Scholar 

  85. Guillen MI, Megias J, Clerigues V, Gomar F, Alcaraz MJ (2008) Rheumatology (Oxford) 47:1323

    CAS  Google Scholar 

  86. Liu DM, Sun BW, Sun ZW, Jin Q, Sun Y, Chen X (2008) Acta Pharmacol Sin 29:838

    CAS  Google Scholar 

  87. Megias J, Guillen MI, Bru A, Gomar F, Alcaraz MJ (2008) J Pharmacol Exp Ther 325:56

    CAS  Google Scholar 

  88. Sun BW, Sun Y, Sun ZW, Chen X (2008) World J Gastroenterol 14:547

    CAS  Google Scholar 

  89. Chen P, Wang G, Sun B, Pan S-h, Jiang H-c (2009) Zhonghua Yixianbing Zazhi 9:181

    CAS  Google Scholar 

  90. Chen P, Sun B, Chen H, Wang G, Pan SH, Kong R, Bai XW, Wang SJ (2010) Cytokine 49:15

    CAS  Google Scholar 

  91. Heo JM, Kim HJ, Ha YM, Park MK, Kang YJ, Lee YS, Seo HG, Lee JH, Yun-Choi HS, Chang KC (2007) Biochem Pharmacol 74:1361

    CAS  Google Scholar 

  92. Kim Y-M, Choi B-M, Kim Y-S, Kwon Y-G, Kibbe MR, Billiar TR, Tzeng E (2008) BMB Rep 41:164

    CAS  Google Scholar 

  93. Scragg JL, Dallas ML, Wilkinson JA, Varadi G, Peers C (2008) J Biol Chem 283:24412

    CAS  Google Scholar 

  94. Scragg JL, Dallas ML, Peers C (2008) Heart 94:e22

    Google Scholar 

  95. Hou SW, Xu R, Heinemann SH, Hoshi T (2008) Proc Nat Acad Sci 105:4039

    CAS  Google Scholar 

  96. Dong D-L, Chen C, Huang W, Chen Y, Zhang X-L, Li Z, Li Y, Yang B-F (2008) Eur J Pharmacol 590:99

    CAS  Google Scholar 

  97. Dallas ML, Scragg JL, Peers C (2009) Adv Exp Med Biol 648:89

    CAS  Google Scholar 

  98. Wilkinson WJ, Gadeberg HC, Harrison AWJ, Allen ND, Riccardi D, Kemp PJ (2009) British J Pharmacol 158:862

    CAS  Google Scholar 

  99. Sun B-W, Jin Q, Sun Y, Sun Z-W, Chen X, Chen Z-Y, Cepinskas G (2007) World J Gastroenterol 13:6183

    CAS  Google Scholar 

  100. Sun B, Sun Z, Jin Q, Chen X (2008) Int J Biol Sci 4:176

    CAS  Google Scholar 

  101. Sun BW, Chen ZY, Chen X, Liu C (2007) J Burn Care Res 28:173

    Google Scholar 

  102. Lee TS, Tsai HL, Chau LY (2003) J Biol Chem 278:19325

    CAS  Google Scholar 

  103. Yuan J-F, Zhang Y-Y, Chen S-C, Tang W-F, Shao D-H (2009) Jiefangjun Yaoxue Xuebao 25:21

    CAS  Google Scholar 

  104. Chen B, Guo LL, Fan CL, Bolisetty S, Joseph R, Wright MM, Agarwal A, George JF (2009) Am J Pathol 175:422

    CAS  Google Scholar 

  105. Nielsen Vance G, Kirklin James K, George James F (2009) Blood Coagul Fibrinolysis 20:377

    CAS  Google Scholar 

  106. Nielsen VG, Kirklin JK, George JF (2010) Blood Coagul Fibrinolysis 21:41

    CAS  Google Scholar 

  107. Nielsen VG, Kirklin JK, George JF (2009) Blood Coagul Fibrinolysis 20:448

    CAS  Google Scholar 

  108. Nielsen VG, Kirklin JK, George JF, Messinger JD (2010) Blood Coagul Fibrinolysis 21:101

    CAS  Google Scholar 

  109. Pae HO, Choi BM, Oh GS, Lee MS, Ryu DG, Rhew HY, Kim YM, Chung HT (2004) Mol Pharmacol 66:122

    CAS  Google Scholar 

  110. Vera T, Henegar JR, Drummond HA, Rimoldi JM, Stec DE (2005) J Am Soc Nephrol 16:950

    CAS  Google Scholar 

  111. Mei D-s, Du Y-a, Wang Y (2007) Zhejiang Da Xue Xue Bao Yi Xue Ban 36:291

    CAS  Google Scholar 

  112. Burger D, Xiang FL, Hammoud L, Lu XR, Feng QP (2009) Am J Physiol Heart Circ Physiol 296:H84

    CAS  Google Scholar 

  113. Czibik G, Sagave J, Martinov V, Ishaq B, Sohl M, Sefland I, Carlsen H, Farnebo F, Blomhoff R, Valen G (2009) Cardiovasc Res 82:107

    CAS  Google Scholar 

  114. Lee BS, Heo J, Kim YM, Shim SM, Pae HO, Kim YM, Chung HT (2006) Biochem Biophys Res Commun 343:965

    CAS  Google Scholar 

  115. Allanson M, Reeve VE (2007) Cancer Immunol Immunother 56:1807

    CAS  Google Scholar 

  116. Vannacci A, Di Felice A, Giannini L, Marzocca C, Pierpaoli S, Zagli G, Masini E, Mannaioni PF (2004) Inflamm Res 53:S9

    CAS  Google Scholar 

  117. Vannacci A, Failli P, Giannini L, Fabrizi F, Uliva C, Mazzetti L, Franchi-Micheli S, Masini E, Motterlini R, Mannaioni PF (2007) Cellular and molecular targets in allergy and clinical immunology. Proc Symp Collegium Int Allergol, 26th:172

    Google Scholar 

  118. Kang KS, Ra JC, Park JR (2007) Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same. Patent US 2007/110729

    Google Scholar 

  119. Oh GS, Pae HO, Moon MK, Choi BM, Yun YG, Rim JS, Chung HT (2003) Biochem Biophys Res Commun 302:109

    CAS  Google Scholar 

  120. Desmard M, Amara N, Lanone S, Motterlini R, Boczkowski J (2005) Cell Mol Biol 51:403

    CAS  Google Scholar 

  121. Zhou J-l, Li G, Hai Y, Guan L, Huang X-l, Sun P (2009) Chin J Traumatol 12:71, English Edition

    CAS  Google Scholar 

  122. Uc A, Husted RF, Giriyappa RL, Britigan BE, Stokes JB (2005) Am J Physiol Gastroint Liver Physiol 289:G202

    CAS  Google Scholar 

  123. Shiohira S, Yoshida T, Shirota S, Tsuchiya K, Nitta K (2007) Am J Nephrol 27:441

    CAS  Google Scholar 

  124. Davies AL, Kramer JLK, Hayes KC (2008) Neuroscience 151:1104

    CAS  Google Scholar 

  125. Knipp S, Bicker G (2009) Development 136:85

    CAS  Google Scholar 

  126. Hidaka A, Azuma Y-T, Nakajima H, Takeuchi T (2010) J Pharmacol Sci 112:231

    CAS  Google Scholar 

  127. Volti GL, Sacerdoti D, Sangras B, Vanella A, Mezentsev A, Scapagnini G, Falck JR, Abraham NG (2005) Antioxid Redox Signal 7:704

    Google Scholar 

  128. Sun B, Zou X, Chen Y, Zhang P, Shi G (2008) Int J Biol Sci 4:270

    CAS  Google Scholar 

  129. Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Valente AJ, Chandrasekar B (2008) Free Radic Biol Méd 44:284

    CAS  Google Scholar 

  130. Nizamutdinova IT, Kim Y-M, Kim H-J, Seo H-G, Lee J-H, Chang K-C (2009) Atheroscler (Amst) 207:405

    CAS  Google Scholar 

  131. Remy S, Blancou P, Tesson L, Tardif V, Brion R, Royer PJ, Motterlini R, Foresti R, Painchaut M, Pogu S, Gregoire M, Bach JM, Anegon I, Chauveau C (2009) J Immunol 182:1877

    CAS  Google Scholar 

  132. Orozco-Ibarra M, Estrada-Sanchez AM, Massieu L, Pedraza-Chaverri J (2009) Int J Biochem Cell Biol 41:1304

    CAS  Google Scholar 

  133. Nobre LS, Seixas JD, Romão CC, Saraiva LM (2007) Antimicrob Agents Chemother 51:4303

    CAS  Google Scholar 

  134. Nobre LS, Seixas JD, Romão CC, Saraiva LM (2008) Treatment of infections by carbon monoxide. Patent WO 2008130261

    Google Scholar 

  135. Nobre LS, Al-Shahrour F, Dopazo J, Saraiva LM (2009) Microbiology-Sgm 155:813

    CAS  Google Scholar 

  136. Chung SW, Liu X, Macias AA, Baron RM, Perrella MA (2008) J Clin Invest 118:239

    CAS  Google Scholar 

  137. Tsoyi K, Lee TY, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC (2009) Mol Pharmacol 76:173

    CAS  Google Scholar 

  138. Sun B, Chen X, Katada K, Potter F, Cepinskas G (2008) Jiangsu Daxue Xuebao Yixueban 18:369

    CAS  Google Scholar 

  139. Sun B, Shi G, Zhang P, Zou X, Chen X (2009) Zhonghua Shaoshang Zazhi 25:111

    Google Scholar 

  140. Sun B, Liu D, Chen X (2009) Application of carbon monoxide-releasing molecules in the treatment of pyohemia in early stage. Patent CN 2008-10038045; 101590228

    Google Scholar 

  141. Han W, Wu L, Chen S, Yu KN (2010) Carcinogenesis 31:275

    CAS  Google Scholar 

  142. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R (2003) Circ Res 93:E2

    CAS  Google Scholar 

  143. Johnson TR, Mann BE, Teasdale IP, Adams H, Foresti R, Green CJ, Motterlini R (2007) Dalton Trans 1500

    Google Scholar 

  144. Seveso M, Vadori M, Bosio E, Boldrin M, Baldan N, Besenzon F, Dedja A, Calabrese F, Busetto R, Ravarotto L, Johnson TR, Mann BE, Motterlini R, Cozzi E, Ancona E (2004) Transplantation 78:222

    Google Scholar 

  145. Seveso M, Vadori M, Bosio E, Fante F, Besenzon F, Ravarotto L, Bedendo S, Johnson TR, Mann BE, Motterlini R, Cozzi E, Ancona E (2005) Am J Transplant 5:306

    Google Scholar 

  146. Vadori M, Seveso M, Besenzon F, Bosio E, Tognato E, Fante F, Boldrin M, Gavasso S, Ravarotto L, Mann Brian E, Simioni P, Ancona E, Motterlini R, Cozzi E (2009) Xenotransplantation 16:99

    Google Scholar 

  147. Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, Motterlini R (2004) Br J Pharmacol 142:453

    CAS  Google Scholar 

  148. Dombkowski RA, Whitfield NL, Motterlini R, Yan G, Olson KR (2009) Am J Physiol 296:R141

    CAS  Google Scholar 

  149. Lamon BD, Zhang FF, Puri N, Brodsky SV, Goligorsky MS, Nasjletti A (2009) Circ Res 105:775

    CAS  Google Scholar 

  150. Guo YR, Stein AB, Wu WJ, Tan W, Zhu XP, Li QH, Dawn B, Motterlini R, Bolli R (2004) Am J Physiol Heart Circul Physiol 286:H1649

    CAS  Google Scholar 

  151. Stein AB, Guo YR, Tan W, Wu WJ, Zhu XP, Li QH, Luo C, Dawn B, Johnson TR, Motterlini R, Bolli R (2005) J Mol Cell Cardiol 38:127

    CAS  Google Scholar 

  152. Varadi J, Lekli I, Juhasz B, Bacskay I, Szabo G, Gesztelyi R, Szendrei L, Varga E, Bak I, Foresti R, Motterlini R, Tosaki A (2007) Life Sci 80:1619

    CAS  Google Scholar 

  153. Musameh MD, Green CJ, Mann BE, Motterlini R, Fuller BJ (2010) J Cardiovasc Pharmacol 55:168

    CAS  Google Scholar 

  154. Li Volti G, Sacerdoti D, Sangras B, Vanella A, Mezentsev A, Scapagnini G, Falck JR, Abraham NG (2005) Antioxid Redox Signal 7:704

    CAS  Google Scholar 

  155. Song H, Bergstrasser C, Rafat N, Hoger S, Schmidt M, Endres N, Goebeler M, Hillebrands JL, Brigelius-Flohe R, Banning A, Beck G, Loesel R, Yard BA (2009) Br J Pharmacol 157:769

    CAS  Google Scholar 

  156. Musameh MD, Fuller BJ, Mann BE, Green CJ, Motterlini R (2006) Br J Pharmacol 149:1104

    CAS  Google Scholar 

  157. Clark JE, Kottam A, Motterlini R, Marber MS (2009) J Pharmacol Toxicol Meth 59:94

    CAS  Google Scholar 

  158. Chlopicki S, Olszanecki R, Marcinkiewicz E, Lomnicka M, Motterlini R (2006) Cardiovasc Res 71:393

    CAS  Google Scholar 

  159. Musameh MD, Green CJ, Mann BE, Fuller BJ, Motterlini R (2007) J Heart Lung Transplant 26:1192

    Google Scholar 

  160. De Backer O, Elinck E, Blanckaert B, Leybaert L, Motterlini R, Lefebvre RA (2009) Gut 58:347

    Google Scholar 

  161. Di Pascoli M, Rodella L, Sacerdoti D, Bolognesi M, Turkseven S, Abraham NG (2006) Biochem Biophys Res Commun 340:935

    Google Scholar 

  162. Rodella LF, Vanella L, Peterson SJ, Drummond G, Rezzani R, Falck JR, Abraham NG (2008) Drug Metab Lett 2:290

    CAS  Google Scholar 

  163. Piepoli AL, de Salvatore G, Lemoli M, de Benedictis L, Mitolo-Chieppa D, de Salvia MA (2008) Neurogastroenterol Motil 20:1251

    CAS  Google Scholar 

  164. Rodella L, Lamon BD, Rezzani R, Sangras B, Goodman AI, Falck JR, Abraham NG (2006) Free Radical Biol Med 40:2198

    CAS  Google Scholar 

  165. Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R (2006) Pharmacol Rep 58(Suppl):132

    Google Scholar 

  166. Vannacci A, Marzocca C, Giannini L, Mazzetti L, Franchi-Micheli S, Failli P, Masini E, Motterlini R, Mannaioni PF (2006) Inflamm Res 55:S5

    CAS  Google Scholar 

  167. Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R (2006) J Pharmacol Exp Ther 318:1315

    CAS  Google Scholar 

  168. Xi Q, Umstot E, Zhao G, Narayanan D, Leffler CW, Jaggar JH (2010) Am J Physiol 298:H562

    CAS  Google Scholar 

  169. Ferrandiz ML, Maicas N, Garcia-Arnandis I, Terencio MC, Motterlini R, Devesa I, Joosten LAB, van den Berg WB, Alcaraz MJ (2008) Ann Rheum Dis 67:1211

    CAS  Google Scholar 

  170. Tayem Y, Johnson TR, Mann BE, Green CJ, Motterlini R (2006) Am J Physiol Renal Physiol 290:F789

    CAS  Google Scholar 

  171. Sandouka A, Fuller BJ, Mann BE, Green CJ, Foresti R, Motterlini R (2006) Kidney Int 69:239

    CAS  Google Scholar 

  172. Stec DE, Bishop C, Rimoldi JM, Poreddy SR, Vera T, Salahudeen AK (2007) Ren Fail 29:543

    CAS  Google Scholar 

  173. Ren Y, D’Ambrosio MA, Wang H, Liu R, Garvin JL, Carretero OA (2008) Am J Physiol Ren Physiol 295:F1207

    CAS  Google Scholar 

  174. Bagul A, Hosgood SA, Kaushik M, Nicholson ML (2008) Transplantation 85:576

    CAS  Google Scholar 

  175. Hosgood SA, Bagul A, Kaushik M, Rimoldi J, Gadepalli RS, Nicholson ML (2008) Br J Surg 95:1060

    CAS  Google Scholar 

  176. Pizarro MD, Rodriguez JV, Mamprin ME, Fuller BJ, Mann BE, Motterlini R, Guibert EE (2009) Cryobiology 58:248

    CAS  Google Scholar 

  177. Dong D-L, Zhang Y, Lin D-H, Chen J, Patschan S, Goligorsky MS, Nasjletti A, Yang B-F, Wang W-H (2007) Hypertension 50:643

    CAS  Google Scholar 

  178. Althaus M, Fronius M, Buchaeckert Y, Vadasz I, Clauss WG, Seeger W, Motterlini R, Morty RE (2009) Am J Respir Cell Mol Biol 41:639

    CAS  Google Scholar 

  179. Urquhart P, Rosignoli G, Cooper D, Motterlini R, Perretti M (2007) J Pharmacol Exp Ther 321:656

    CAS  Google Scholar 

  180. Mizuguchi S, Stephen J, Bihari R, Markovic N, Suehiro S, Capretta A, Potter Richard F, Cepinskas G (2009) Am J Physiol 297:H920

    CAS  Google Scholar 

  181. Aziz MTA, El-Asmar MF, Mostafa T, Atta H, Fouad HH, Roshdy NK, Rashed LA, Obaia EA, Sabry DA, Aziz ATA, Drummond G, Olszanecki R (2008) J Sex Med 5:336

    CAS  Google Scholar 

  182. Barbagallo I, Tibullo D, Di Rosa M, Giallongo C, Palumbo GA, Raciti G, Campisi A, Vanella A, Green CJ, Motterlini R (2008) J Neurosci Res 86:1927

    CAS  Google Scholar 

  183. Masini E, Vannacci A, Failli P, Mastroianni R, Giannini L, Vinci MC, Uliva C, Motterlini R, Mannaioni PF (2008) FASEB J 22:3380

    CAS  Google Scholar 

  184. Vannacci A, Giannini L, Fabrizi F, Uliva C, Mastroianni R, Masini E, Motterlini R, Mannaioni PF (2007) Inflamm Res 56:S13

    CAS  Google Scholar 

  185. Stagni E, Privitera MG, Bucolo C, Leggio GM, Motterlini R, Drago F (2009) Br J Ophthalmol 93:254

    CAS  Google Scholar 

  186. Hascalovici JR, Song W, Vaya J, Khatib S, Fuhrman B, Aviram M, Schipper HM (2009) J Neurochem 108:72

    CAS  Google Scholar 

  187. Lancel S, Hassoun SM, Favory R, Decoster B, Motterlini R, Neviere R (2009) J Pharmacol Exp Ther 329:641

    CAS  Google Scholar 

  188. Romão CC, Rodrigues SS, Seixas JD, Pina ARM, Roya B, Fernandes AC, Goncalves I, Haas W (2007) Method using CO-releasing molybdenum carbonyl complexes for the treatment of inflammatory diseases. Patent WO 2007/073226

    Google Scholar 

  189. Desmard M, Davidge KS, Bouvet O, Morin D, Roux D, Foresti R, Ricard JD, Denamur E, Poole RK, Montravers P, Motterlini R, Boczkowski J (2009) FASEB J 23:1023

    CAS  Google Scholar 

  190. Herrmann F, List H (1995) Transdermal therapeutic system comprosong active substances representing carbon monoxide sources. Patent WO 95/35105

    Google Scholar 

  191. Winslow RM (2006) Composition and methods for delivering carbon monoxide (CO) and nitric oxide (NO) to tissue using heme proteins as carriers. Patent WO 2006/096774

    Google Scholar 

  192. Vandegriff KD, Young MA, Lohman J, Bellelli A, Samaja M, Malavalli A, Winslow RM (2008) Br J Pharmacol 154:1649

    CAS  Google Scholar 

  193. Motterlini RA, Mann BE, Johnson TR, Scapens DA, Aqil R (2007) Therapeutic delivery of carbon monoxide via organometallic complexes. Patent WO 2007/085806

    Google Scholar 

  194. Scapens D, Adams H, Johnson TR, Mann BE, Sawle P, Aqil R, Perrior T, Motterlini R (2007) Dalton Trans 43:4962

    Google Scholar 

  195. Fairlamb IJS, Lynam JM, Moulton BE, Taylor IE, Duhme-Klair AK, Sawle P, Motterlini R (2007) Dalton Trans 3603

    Google Scholar 

  196. Fairlamb IJS, Duhme-Klair AK, Lynam JM, Moulton BE, O’Brien CT, Sawle P, Hammad J, Motterlini R (2006) Bioorg Med Chem Lett 16:995

    CAS  Google Scholar 

  197. Sawle P, Hammad J, Fairlamb IJS, Moulton B, O’Brien CT, Lynam JM, Duhme-Klair AK, Foresti R, Motterlini R (2006) J Pharmacol Exp Ther 318:403

    CAS  Google Scholar 

  198. Zhang W-Q, Atkin AJ, Thatcher RJ, Whitwood AC, Fairlamb IJS, Lynam JM (2009) Dalton Trans 4351

    Google Scholar 

  199. Fiumana E, Parfenova H, Jaggar JH, Leffler CW (2003) Am J Physiol Heart Circul Physiol 284:H1073

    CAS  Google Scholar 

  200. Barkoudah E, Jaggar JH, Leffler CW (2004) Am J Physiol Heart Circul Physiol 287:H1459

    CAS  Google Scholar 

  201. Koneru P, Leffler CW (2004) Am J Physiol Heart Circ Physiol 286:H304

    CAS  Google Scholar 

  202. Xi Q, Tcheranova D, Parfenova H, Horowitz B, Leffler CW, Jaggar JH (2004) Am J Physiol Heart Circ Physiol 286:H610

    CAS  Google Scholar 

  203. Arregui B, Lopez B, Salom MG, Valero F, Navarro C, Fenoy FJ (2004) Kidney Int 65:564

    CAS  Google Scholar 

  204. Motterlini RA, Mann BE, Scapens DA (2008) Therapeutic delivery of carbon monoxide. Patent WO 2008/003953

    Google Scholar 

  205. Niesel J, Pinto A, N’Dongo HWP, Merz K, Ott I, Gustb R, Schatzschneider U (2008) Chem Comm 1798

    Google Scholar 

  206. Pfeiffer H, Rojas A, Niesel J, Schatzschneider U (2009) J Chem Soc, Dalton Trans 4292

    Google Scholar 

  207. Kunz PC, Huber W, Rojas A, Schatzschneider U, Spingler B (2009) Eur J Inorg Chem 5358

    Google Scholar 

  208. Haas W, Romão CC, Rodrigues SS, Seixas JD, Pina ARM (2007) Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases. Patent WO 2007/073225

    Google Scholar 

  209. Rodrigues SS, Seixas JD, Guerreiro B, Pereira NMP, Romao CC, Haas WE, Goncalves IMDS (2009) Prevention of gastric ulcers by carbon monoxide. Patent 2008-IB1945; WO 2009/013612

    Google Scholar 

  210. Rimmer RD, Richter H, Ford PC (2010) Inorg Chem 49:1180

    CAS  Google Scholar 

  211. Atkin AJ, Williams S, Sawle P, Motterlini R, Lynam JM, Fairlamb IJS (2009) Dalton Trans 3653

    Google Scholar 

  212. Malone LJ Jr, Parry RW (1967) Inorg Chem 6:817

    CAS  Google Scholar 

  213. Alberto RA (2001) Carbon monoxide source for preparation of transition metal carbonyl complexes. Patent WO 2001/025243

    Google Scholar 

  214. Motterlini RA, Alberto RA (2005) Use of boranocarbonates for the therapeutic delivery of carbon monoxide. Patent WO 2005/013691

    Google Scholar 

  215. Motterlini R, Sawle P, Bains S, Hammad J, Alberto R, Foresti R, Green CJ (2004) FASEB J 19:284

    Google Scholar 

  216. Kelsen S, Patel BJ, Parker LB, Vera T, Rimoldi JM, Gadepalli RSV, Drummond HA, Stec DE (2008) Am J Physiol Ren Physiol 295:F1158

    CAS  Google Scholar 

  217. Stec DE, Vera T, McLemore GR Jr, Kelsen S, Rimoldi JM, Gadepalli RSV, Ryan MJ (2008) Am J Hypertens 21:189

    CAS  Google Scholar 

  218. Wegiel B, Gallo DJ, Raman KG, Karlsson JM, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed A, Baty CJ, Otterbein LE (2010) Circulation 121:537

    CAS  Google Scholar 

  219. Ryan MJ, Jernigan NL, Drummond HA, McLemore GR, Rimoldi JM, Poreddy SR, Gadepalli RSV, Stec DE (2006) Pharmacol Res 54:24

    CAS  Google Scholar 

  220. Zimmermann A, Leffler CW, Tcheranova D, Fedinec AL, Parfenova H (2007) Am J Physiol 293:H2501

    CAS  Google Scholar 

  221. Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H (2006) Am J Physiol 291:C897

    CAS  Google Scholar 

  222. Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW (2006) Am J Physiol Cell Physiol 290:C1399

    CAS  Google Scholar 

  223. Basuroy S, Bhattacharya S, Leffler CW, Parfenova H (2009) Am J Physiol 296:C422

    CAS  Google Scholar 

  224. Wu L, Wang R, Ndisang JF (2006) Chronic hemin treatment of vascular diseases. Patent CA 2005/2504643

    Google Scholar 

  225. Buelow R, Woo J (2002) Carbon monoxide-generating compounds for treatment of vascular, inflammatory and immune disorders. Patent WO 2002/078684

    Google Scholar 

  226. Buelow R, Woo J, Iyer S (2004) Carbon monoxide generating compounds for treatment of vascular inflammatory and immune disorders. Patent US 2004/0143025

    Google Scholar 

  227. De Matos MN, Romão CC (2007) Methods for treating inflammatory disease by administering aldehydes and derivatives thereof. Patent US 2007/219120

    Google Scholar 

  228. De Matos MN, Romão CC (2008) Methods for treating inflammatory disease by administering aldehydes and derivatives thereof. Patent US 2008/026984

    Google Scholar 

  229. Battino R (1990) Carbon monoxide, vol 43, Solubility data series. Pergamon, Headington Hill Hall, p 2

    Google Scholar 

  230. Peng C (1990) Chromatographia 29:347

    CAS  Google Scholar 

  231. Giner JD (1986) Gas sensor and method of using same. Patent US 4729824

    Google Scholar 

  232. Motterlini RA (2005) Electrode calibration. Patent WO 2005/114161

    Google Scholar 

  233. Bowen WJ (1949) J Biol Chem 179:235

    CAS  Google Scholar 

  234. Pathak B, Majumdar D, Leszczynski J (2009) Int J Quantum Chem 109:2263

    CAS  Google Scholar 

  235. Acute Exposure Levels Guidelines http://www.epa.gov/oppt/aegl/pubs/chemlist.htm. Accessed: 10 Jan 2009

  236. Ren Y, D’Ambrosio MA, Wang H, Liu RS, Garvin JL, Carretero OA (2008) Am J Physiol Renal Physiol 295:F1207

    CAS  Google Scholar 

  237. Motterlini R (2007) Biochem Soc Trans 35:1142

    CAS  Google Scholar 

  238. Haas W, Romão C, Royo B, Fernandes AC, Goncalves I (2003) Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof. Patent WO 2003/066067

    Google Scholar 

  239. Motterlini RA, Mann BE (2004) Therapeutic delivery of carbon monoxide using metal carbonyl complexes. Patent WO 2004/045598

    Google Scholar 

  240. Motterlini RA, Mann BE (2004) Combination of a metal carbonyl compound and a guanylate cyclase stimulant or stabilizer for the therapeutic delivery of carbon monoxide. Patent WO 2004/045599

    Google Scholar 

  241. Matos MRPN, Romão CC, Lage Pereira CC, Rodrigues SS, Mora M, Silva MJP, Alves PM, Reis CA (2005) Compositions comprising organometallic molybdenum compounds for treating cancer. Patent WO 2005/087783

    Google Scholar 

  242. Haas WE, Romão CC, Rodrigues SS, Seixas JD, Pina ARM, Royo B, Fernandes AC, Goncalves I (2007) Method for treating a mammal by administration of a compound having the ability to release CO. Patent US 2007/207217

    Google Scholar 

  243. DiSorbo DM, Reeves R (1994) Compositions including heme-containing proteis and methods relating thereto. Patent WO 94/22482

    Google Scholar 

  244. Tsuchida H, Sakai H, Intaliertta M (2007) Intravenous fluids containing heme with carbon monooxide or nitrogen monooxide. Patent JP 2007/269665

    Google Scholar 

  245. Takagi T, Naito Y, Okuda T, Suzuki T, Mizushima K, Tsuboi H, Kajikawa H, Okayama T, Omatsu T, Hirata I, Ichikawa H, Handa O, Furukura S, Yoshida N, Yoshikawa T, Ueda H (2008) Drugs for local intestinal administration, and method for administration of drugs. Patent JP 2008/179569

    Google Scholar 

  246. Capelli CC, Dennis AP (2008) Devices such as soft tissue implants and methods for inhibiting fibrosis comprising non-gaseous CO with anti-fibrotic activity. Patent WO 2008/080128

    Google Scholar 

  247. Hoenig M (2007) A method of treatment and prophylaxis of events, conditions and diseases of the systemic vasculature and immune function to decrease cardiovascular risk and pathogenic infection. Patent WO 2007/140525 (A1)

    Google Scholar 

  248. Chung HT, Pae HO, Choi BM (2006) Composition for treating autoimmune disease comprising heme oxygenase-1 inducer or CO donor capable of inhibiting proliferation of CD4+ T-cell causing autoimmune disease. Patent KR 2006/034061

    Google Scholar 

  249. Cheesman MR, Watmough NJ, Pires CA, Turner R, Brittain T, Gennis RB, Greenwood C, Thomson AJ (1993) Biochem J 289:709

    CAS  Google Scholar 

  250. Davidge KS, Sanguinetti G, Yee CH, Mann BE, Motterlini R, Poole RK (2009) J Biol Chem 284:4516

    CAS  Google Scholar 

  251. Zuckerbraun BS (2008) Expert Opin Ther Pat 18:1321

    CAS  Google Scholar 

Download references

Acknowledgments

I wish to thank Dr R. Motterlini for reading the manuscript and providing valuable modifications. I also wish to thank Hemocorm (now Alfama) for financial support and declare a financial interest in the company.

Author information

Authors and Affiliations

  1. Department of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK

    Brian E. Mann

Authors
  1. Brian E. Mann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brian E. Mann .

Editor information

Editors and Affiliations

  1. Chimie de Paris (ENSCP), Ecole Nationale Superieure de, rue Pierre et Marie Curie 11, Paris CX 05, 75231, France

    Gérard Jaouen

  2. LS für Anorganische Chemie I -, Bioanorganische Chemie, Universität Bochum, Universitätsstr. 150, Bochum, 44801, Germany

    Nils Metzler-Nolte

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mann, B.E. (2010). Carbon Monoxide: An Essential Signalling Molecule. In: Jaouen, G., Metzler-Nolte, N. (eds) Medicinal Organometallic Chemistry. Topics in Organometallic Chemistry, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13185-1_10

Download citation

Publish with us

Policies and ethics

Search

Navigation