Skip to main content
SpringerLink
Log in

Skelettsystemerkrankungen

  • Chapter
Orthopädie und Unfallchirurgie

  • 12k Accesses

Zusammenfassung

Wie der Begriff schon sagt, ist bei diesem Krankheitsbild nicht ein einzelnes Organ betroffen. Vielmehr handelt es sich um multiple Störungen, die nicht nur den Bewegungsapparat betreffen. Gemeinsam ist diesen Erkrankungen, dass sie mit nur wenigen Ausnahmen erblich sind und somit als Heredopathien bezeichnet werden und dass sie in aller Regel mit einem Klein- oder Zwergwuchs einhergehen (Endgröße von <150 cm). Obwohl diese Erkrankungen sehr heterogene Auswirkungen haben, ist es insbesondere der Kleinwuchs, der in der Gesellschaft des 21. Jahrhunderts mit ihren hohen ästhetischen Anforderungen im Vordergrund steht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 239.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 259.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Agarwal V, Joseph B (2005) Non-union in osteogenesis imperfecta. J Pediatr Orthop B 14: 451–455

    Article  PubMed  Google Scholar 

  • Aldenhoven M, Sakkers RJ, Boelens J (2009) Musculoskeletal manifestations of lysosomal storage disorders. Ann Rheum Dis 68: 1659–1665

    Article  PubMed  CAS  Google Scholar 

  • Ankrom MA, Shapiro JR (1998) Paget’s disease of bone (osteitis deformans). J Am Geriatr Soc 46: 1025–1033

    PubMed  CAS  Google Scholar 

  • Aroldi A, Tarantino A, Montagnino G, Cesana B, Cocucci C, Ponticelli C (1997) Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: a prospective study. Transplantation 63: 380–386

    Article  PubMed  CAS  Google Scholar 

  • Bailey K (1963) Studies of longitudinal bone grosth resulting in an extensible nail. Surg Forum 14: 455

    PubMed  CAS  Google Scholar 

  • Baumert U, Golan I, Redlich M, Aknin JJ, Muessig D (2005) Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group. Am J Med Gen 139A (2): 78–85

    Article  CAS  Google Scholar 

  • Beck M (2007) Lysosomale Speicherkrankheiten. Monatsschr Kinderheilkd 155: 653–662

    Article  Google Scholar 

  • Beckmann J, Köck F, Tingart M, Goetz J, Grifka J, Schaumburger J (2008) Pseudarthrosis in fibrous dysplasia treated with BMP. CEJMed 3: 377–379

    Google Scholar 

  • Black D et al. (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356: 1809–1822

    Article  PubMed  CAS  Google Scholar 

  • Black DM, Greenspan SL, Ensrud KE et al. (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349: 1207–1215

    Article  PubMed  CAS  Google Scholar 

  • Bone HG, Kleerekoper M (1992) Clinical review 39: Paget’s disease of bone. J Clin Endocrinol Metab 75: 1179–1182

    Article  PubMed  CAS  Google Scholar 

  • Bourke E, Delaney V (1993) Assessment of hypocalcemia and hypercalcemia. Clin Lab Med 13: 157–181

    PubMed  CAS  Google Scholar 

  • Boutaud B, Laville J M (2004) L’embrochage centro-medullaire coulissant dans l’osteogenese imparfaite. Quatorze cas avec un recul moyen de 8 ans. Rev Chir Orthop Reparatrice Appar Mot 90: 304–311

    Article  PubMed  CAS  Google Scholar 

  • Bovée JV (2008) Multiple osteochondromas. Orphanet J Rare Dis 3: 3

    Article  PubMed  Google Scholar 

  • Cho T J, Choi IH, Chung CY, Yoo WJ, Lee KS, Lee DY (2007) Interlocking telescopic rod for patients with osteogenesis imperfecta. J Bone Joint Surg Am 89: 1028–1035

    Article  PubMed  Google Scholar 

  • Daly K, Wisbeach A, Sanpera I, Fixsen JA (1996) The prognosis for walking in osteogenesis imperfecta. J Bone Joint Surg Br 78: 477–480

    PubMed  CAS  Google Scholar 

  • DiCaprio MR, Enneking WF (2005) Fibrous dysplasia. Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am 87: 1848–1864

    Article  PubMed  Google Scholar 

  • Drake WM, Kendler DL, Brown JB (2001) Consensus statement on the modern therapy of Paget’s disease of bone from a western osteoporosis alliance symposium. Clin Ther 23: 620–626

    Article  PubMed  CAS  Google Scholar 

  • Enderle A (2003) Osteochondrodysplasien. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 34–36

    Google Scholar 

  • Engelbert RH, Uiterwaal CS, Gerver WJ, Van Der Net JJ, Pruijs HE, Helders PJ (2004) Osteogenesis imperfecta in childhood: impairment and disability. A prospective study with 4-year follow-up. Arch Phys Med Rehabil 85: 772–778

    Article  PubMed  Google Scholar 

  • Engelbert RH, Uiterwaal CS, Gulmans VA, Pruijs HE, Helders PJ (2000) Osteogenesis imperfecta: profiles of motor development as assessed by a postal questionnaire. Eur J Pediatr 159: 615–620

    Article  PubMed  CAS  Google Scholar 

  • Ettinger B, Black DM, Mitlak BH et al. (1999) Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene. JAMA 282: 637–645

    Article  PubMed  CAS  Google Scholar 

  • Garnero P, Hausherr E, Chapuy MC et al. (1996) Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res 11: 1531–1538

    Article  PubMed  CAS  Google Scholar 

  • Gerber LH, Binder H, Weintrob J et al. (1990) Rehabilitation of children and infants with osteogenesis imperfecta. A program for ambulation. Clin Orthop Relat Res 251: 254–262

    PubMed  Google Scholar 

  • Golan I, Baumert U, Hrala BP et al. (2003) Symptome und Merkmale bei Dysostosis Cleidocranialis. Z Orthop 141: 336–340

    Article  PubMed  CAS  Google Scholar 

  • Gray JR, Davies SJ (1996) Marfan syndrome. J Med Genet 33: 403–408

    Article  PubMed  CAS  Google Scholar 

  • Grennberg B, Winters RW, Graham JB (1960) The normal range of serum inorganic phosphorus and its utility as a discriminant in the diagnosis of congenital hypophosphatemia. J Clin Endocr Metab 20: 364–379

    Article  Google Scholar 

  • Harrison WJ, Rankin KC (1998) Osteogenesis imperfecta in Zimbabwe: a comparison between treatment with intramedullary rods of fixed-length and self-expanding rods. J R Coll Surg Edinb 43: 328–332

    PubMed  CAS  Google Scholar 

  • Hefti F (2006a) Skelettdysplasien. In: Hefti F (Hrsg.) KinderOrthopädie in der Praxis. Springer, Berlin Heidelberg New York Tokyo, S. 649–684

    Google Scholar 

  • Hefti F (2006b) Neurofibromatose. In: Hefti F (Hrsg.) KinderOrthopädie in der Praxis. Springer, Berlin Heidelberg New York Tokyo, S. 697–699

    Google Scholar 

  • Hellemans J et al. (2004) Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet 36: 1213–1218

    Article  PubMed  CAS  Google Scholar 

  • Herring JA (2008) Tachdjian’s pediatric orthopaedics. Saunders Elsevier, Philadelphia

    Google Scholar 

  • Horton WA, Hall JG, Hecht JT (2007) Achondroplasia. Lancet 370: 162–172

    Article  PubMed  CAS  Google Scholar 

  • Hosking D et al. (1996) Paget’s disease of bone: diagnosis and management. BMJ 312: 491–494

    Article  PubMed  CAS  Google Scholar 

  • Joseph B, Rebello G, BCK (2005) The choice of intramedullary devices for the femur and the tibia in osteogenesis imperfecta. J Pediatr Orthop B 14: 311–319

    Article  PubMed  Google Scholar 

  • Julian BA, Laskow DA, Dubovsky J, Dubovsky EV, Curtis JJ, Quarles LD (1991) Rapid loss of vertebral mineral density after renal transplantation. N Engl J Med 325: 544–550

    Article  PubMed  CAS  Google Scholar 

  • Jundt G, Baumhoer D (2008) Chondrogene Tumoren des Skeletts. Pathologe 29: 223–231

    Article  PubMed  Google Scholar 

  • Karbowski A, Schwitalle M, Eckardt A (1998) Erfahrungen mit unterschiedlichen Teleskopnägeln zur Behandlung kindlicher Osteogenesis imperfecta-Patienten. Zentralbl Chir 123: 1252–1256

    PubMed  CAS  Google Scholar 

  • Kehrer-Sawatzki H, Mautner VF (2009) Klinik und Genetik der Neurofibromatose Typ I. Med Gen 21: 519–531

    CAS  Google Scholar 

  • Kohler G (2005) Tumorartige Läsionen und benigne Knochentumoren. In: Winkelmann W (Hrsg.) Tumoren, tumorahnliche Erkrankungen. Stuttgart: Thieme, S. 79

    Google Scholar 

  • Kornak U (2004) Genetik und Pathophysiologie der Osteopetrose. Med Gen 16: 39–43

    CAS  Google Scholar 

  • Link B, Miebach E, Vetter T, Schmitt D, Beck M, Meurer A (2008) Mukopolysaccharidosen. Orthopädie 37: 24–30

    Article  CAS  Google Scholar 

  • Luhmann SJ, Sheridan JJ, Capelli AM, Schoenecker PL (1998) Management of lower-extremity deformities in osteogenesis imperfecta with extensible intramedullary rod technique: a 20-year experience. J Pediatr Orthop 18: 88–94

    Article  PubMed  CAS  Google Scholar 

  • Marshall D, Johnell O, Wedel H (1996) Metaanalysis of how well measures of bone mineral density predict occurence of osteoporotic fractures. BMJ 12: 1254–1259

    Article  Google Scholar 

  • McClatchey AI (2007) Neurofibromatosis. Annu Rev Pathol Mech Dis 2: 191–216

    Article  CAS  Google Scholar 

  • McClung MR, Geusens P, Miller PD et al. (2001) Effect of risedronate on the risk of hip fracture in elderly women. N Engl J Med 344: 333–340

    Article  PubMed  CAS  Google Scholar 

  • Meunier PJ, Roux C, Seeman E et al. (2004) The effects of strontium ranelate on the risk of vertebral fracture in woman with postmenopausal osteoporosis. N Engl J Med 350: 459–468

    Article  PubMed  CAS  Google Scholar 

  • Mulpuri K, Joseph B (2000) Intramedullary rodding in osteogenesis imperfecta. J Pediatr Orthop 20: 267–273

    Article  PubMed  CAS  Google Scholar 

  • Munns CF, Rauch F, Zeitlin L, Fassier F, Glorieux FH (2004) Delayed osteotomy but not fracture healing in pediatric osteogenesis imperfecta patients receiving pamidronate. J Bone Miner Res 19: 1779–1786

    Article  PubMed  CAS  Google Scholar 

  • Neer RM et al. (2001) Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344: 1434–1441

    Article  PubMed  CAS  Google Scholar 

  • NIH (1988) Neurofibromatosis. National Health Consensus Development Conference Statement, Bethesda, MD, USA, July 13–15, 1987. Neurofibromatosis 1: 172–178

    Google Scholar 

  • Parekh SG, Donthineni-Rao R, Ricchetti E, Lackman RD (2004) Fibrous dysplasia. J Am Acad Orthop Surg 12: 305–313

    PubMed  Google Scholar 

  • Paterson CR, Naismith KI, Young JA (1992) Severe unexplained hypophosphatemia. Clin Chem 38: 104–107

    PubMed  CAS  Google Scholar 

  • Payne RB, Carver ME, Morgan DB (1979) Interpretation of total calcium: effects of adjustment for albumin concentration of frequency of abnormal values and on detection of change in the individual. J Clin Pathol 32: 56–60

    Article  PubMed  CAS  Google Scholar 

  • Pizones J, Plotkin H, Parra-Garcia JI et al. (2005) Bone healing in children with osteogenesis imperfecta treated with bisphosphonates. J Pediatr Orthop 25: 332–335

    Article  PubMed  Google Scholar 

  • Pollandt K, Engels S, Werner M, Delling G (2002) Fibröse Dysplasie. Pathologe 23: 351–356

    Article  PubMed  CAS  Google Scholar 

  • Pons F, Martinez de Osaba MJ (1995) Evolution of bone mineral density after renal transplantation: related factors. Nephrol Dial Transplant 10 (Suppl 6): 111–113

    PubMed  Google Scholar 

  • Reid IR, Miller P, Lyles K et al. (2005) A single infusion of zoledronic acid improves remission rates in Paget’s disease: a randomized controlled comparision with risedronate. N Engl J Med 353: 898–908

    Article  PubMed  CAS  Google Scholar 

  • Ring D, Jupiter JB, Labropoulos PK, Guggenheim JJ, Stanitsky DF, Spencer DM (1996) Treatment of deformity of the lower limb in adults who have osteogenesis imperfecta. J Bone Joint Surg Am 78: 220–225

    PubMed  CAS  Google Scholar 

  • Rödl R, Götze C (2008) Fibröse Dysplasie. Orthopädie 37: 49–55

    Article  Google Scholar 

  • Rogers MJ, Gordon S, Benford HL et al. (2000) Cellular and molecular mechanisms of action of bisphosphonates. Cancer 88: 2961–2978

    Article  PubMed  CAS  Google Scholar 

  • Rossouw JE, Anderson GL, Prentice RL et al. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288: 321–333

    Article  PubMed  CAS  Google Scholar 

  • Saldanha KA, Saleh M, Bell MJ, Fernandes JA (2004) Limb lengthening and correction of deformity in the lower limbs of children with osteogenesis imperfecta. J Bone Joint Surg Br 86: 259–265

    Article  PubMed  CAS  Google Scholar 

  • Sanchez CP, Goodman WG, Salusky IB (1999) Prevention of renal osteodystrophy in predialysis patients. Am J Med Sci 317: 398–404

    Article  PubMed  CAS  Google Scholar 

  • Seebach C, Kurth A, Marzi I (2007) Einfluss der Bisphosphonate auf die Frakturheilung. Orthopädie 36: 136–140

    Article  CAS  Google Scholar 

  • Selby PL, Davie MW, Ralston SH, Stone MD, Bone and Tooth Society Great Britain, National Association for the Relief of Paget’s Disease (2002) Guidelines on the management of Paget’s disease of bone. Bone 31: 366–373

    Article  PubMed  CAS  Google Scholar 

  • Siris ES (1999) Goals of treatment for Paget’s disease of bone. J Bone Miner Res 14 (Suppl 2): 49–52

    Article  PubMed  Google Scholar 

  • Sliman N (1981) Osteogenesis imperfecta: An expanding panorama of variants. Clin Orthop Relat Res 159: 11–25

    Google Scholar 

  • Spranger J (1992) International classification of osteochondrodysplasias, international working-group on constitutional disease of bone. Eur J Pediat 151: 407–415

    Article  CAS  Google Scholar 

  • Stott NS, Zionts LE (1993) Displaced fractures of the apophysis of the olecranon in children who have osteogenesis imperfecta. J Bone Joint Surg Am 75: 1026–1033

    PubMed  CAS  Google Scholar 

  • Tolar (2004) Osteopetrosis. N Engl J Med 351: 2839–2849

    Article  PubMed  Google Scholar 

  • Uebelhart D, Gineyts E, Chapuy MC, Delmas PD (1990) Urinary excretion of pyridinium links; a new marker of bone resorption in metabolic bone disease. Bone Miner 8: 87–96

    Article  PubMed  CAS  Google Scholar 

  • Weber U, Robinson Y, Kayser R (2006) Seltene krankhafte Veranderungen der oberen Halswirbelsäule mit operativer Behandlungsindikation. Orthopädie 35: 296–305

    Article  CAS  Google Scholar 

  • Woitge HW, Seibel MJ, Ziegler R (1996) Comparison of total and bonespecific alkaline phosphatase in patients with nonskeletal disorders or metabolic bone diseases. Clin Chem 42: 1796–1804

    PubMed  CAS  Google Scholar 

  • Wong GL (1979) Basal activities and hormone responsiveness of osteoblastic activity. J Biol Chem 254: 6337–6340

    PubMed  CAS  Google Scholar 

  • Zichner (2003a) Osteochondrodysplasien. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 45–47

    Google Scholar 

  • Zichner L (2003b) Osteopetrose. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 129–132

    Google Scholar 

  • Zichner L (2003c) Osteopoikilie. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 136–137

    Google Scholar 

  • Zichner L (2007) Angebohrene Skelettsystemerkrankungen. In: Wirth CJ, Mutschler W (Hrsg.) Praxis der Orthopädie und Unfallschirurgie. Stuttgart: Thieme, S. 111

    Google Scholar 

  • Zichner L, Enderle A (2003) Down-Syndrom. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 99–102

    Google Scholar 

  • Zichner L, Enderle A (2003a) Mukopolysaccharidosen. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 75–83

    Google Scholar 

  • Zichner L, Enderle A (2003b) Oligosaccharidosen. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 83–84

    Google Scholar 

  • Zichner L, Enderle A (2003c) Osteochondrodysplasien. In: Zichner L (Hrsg.) Systemerkrankungen. Stuttgart: Thieme, S. 17–28

    Google Scholar 

  • Zionts LE, Ebramzadeh E, Stott NS (1998) Complications in the use of the Bailey-Dubow extensible nail. Clin Orthop Relat Res 348: 186–195

    Article  PubMed  Google Scholar 

Internetadressen

Download references

Author information

Authors and Affiliations

  1. Asklepios Klinikum Bad Abbach GmbH, Orthopädische Klinik für die Universität Regensburg, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach

    Prof. Dr. med. Joachim Grifka

  2. Klinik für Orthopädische Chirurgie und Traumatologie, Kantonsspital St.Gallen, Rorschacher Str. 95, 9007, St. Gallen

    Prof. Dr. med. Markus Kuster

  3. School of Surgery, The University of Western Australia Perth, 35 Stirling Highway, Crawley, 6009, Perth, Australia

    Prof. Dr. med. Markus Kuster

Authors
  1. Prof. Dr. med. Joachim Grifka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. med. Markus Kuster
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Asklepios Klinikum Bad Abbach GmbH, Orthopädische Klinik für die Universität Regensburg, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach

    Joachim Grifka

  2. Klinik für Orthopädische Chirurgie und Traumatologie, Kantonsspital St.Gallen, Rorschacher Str. 95, 9007, St. Gallen

    Markus Kuster

  3. School of Surgery, The University of Western Australia Perth, 35 Stirling Highway, Crawley, 6009, Perth, Australia

    Markus Kuster

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Grifka, J., Kuster, M. (2011). Skelettsystemerkrankungen. In: Grifka, J., Kuster, M. (eds) Orthopädie und Unfallchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13111-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-13111-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-13110-3

  • Online ISBN: 978-3-642-13111-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation