Abstract
Mesenchymal stem cells (MSC) are self-renewing, multipotent cells that are present in many adult tissues, adipose, bone marrow, trabecular bone and muscle. Dermal skin-derived fibroblasts exhibit mesenchymal surface antigen immunophenotype and differentiation along the three main mesenchymal tissue (bone, fat and cartilage). We isolated human dermal fibroblasts from 4 patients with Hereditary Hemorrhagic Telangiectasia (HHT) and from 2 healthy controls. The aim of this work was to evaluate the mesenchymal property of HHT cells in comparison with the control cells. HHT cells possesses the same surface markers expression of mesenchymal stem cells, they are highly clonogenic, showing a high proliferation potential and an enhanced capacity of self renewal.
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© 2010 International Federation for Medical and Biological Engineering
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Silvani, G. et al. (2010). Enhanced stem cells characteristic of fibroblastic mesenchymal cells from HHT patients. In: Bamidis, P.D., Pallikarakis, N. (eds) XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010. IFMBE Proceedings, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13039-7_152
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DOI: https://doi.org/10.1007/978-3-642-13039-7_152
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13038-0
Online ISBN: 978-3-642-13039-7
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