Abstract
Reservosomes are lysosome-related organelles (LROs) of Trypanosoma cruzi with the special capacity of nutrient storage and hydrolase accumulation. They represent the final compartment of epimastigote endocytic pathway and the site of activity of cruzipain, the major T. cruzi protease. They are essential for epimastigote differentiation into trypomastigote infective forms. Trypomastigotes, as well as amastigotes, present related LROs that do not have storage capacity. Typical epimastigote reservosomes have an electrondense protein matrix in which planar membrane units, rare vesicles, and lipid inclusions are immersed. More than 700 proteins are identified in reservosome proteome, confirming the known organelle functions and indicating its participation in other still unexplored pathways.
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Acknowledgments
The authors received financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação Carlos Chagas Filho de Amparo à Pesquisa no Estado do Rio de Janeiro (FAPERJ), and Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES).
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Cunha-e-Silva, N.L., Sant’Anna, C., Pereira, M.G., de Souza, W. (2010). Reservosomes of Trypanosoma cruzi . In: de Souza, W. (eds) Structures and Organelles in Pathogenic Protists. Microbiology Monographs, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12863-9_5
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