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Therapie mit Granulozyten

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Transfusionsmedizin und Immunhämatologie

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Zusammenfassung

Infektionen im Zusammenhang mit schweren Neutropenien sind nach wie vor eine der Hauptursachen für Morbidität und Mortalität bei Patienten, die mit aggressiver Chemotherapie oder einer Transplantation hämatopoetischer Stammzellen behandelt wurden. Es liegt nahe, den Mangel an neutrophilen Granulozyten bei diesen Patienten durch eine Granulozytentransfusion beheben zu wollen. Die Einführung potenter Wachstumsfaktoren (G-CSF) und geeigneter Präparationstechniken ermöglicht heute die Bereitstellung funktionsfähiger Granulozyten in ausreichender Zahl, doch fehlen bislang überzeugende, randomisierte klinische Studien, die den klinischen Nutzen dieser Therapie belegen. Trotzdem haben erfolgversprechende kleinere Arbeiten das Interesse an dieser Therapieform wiederbelebt.

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Author information

Authors and Affiliations

  1. DRK-Blutspendedienst West gemeinnützige GmbH, Feithstr. 182, 58097, Hagen

    Prof. Dr. J. Bux

  2. Institut für klinische Immunologie u. Transfusionsmedizin, Universitätsklinikum Gießen, Langhansstr. 7, 35392, Gießen

    PD Dr. U. J. H. Sachs

Authors
  1. Prof. Dr. J. Bux
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  2. PD Dr. U. J. H. Sachs
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Editor information

Editors and Affiliations

  1. Abteilung für Transfusionsmedizin, Universitätsklinikum Rostock AöR, Ernst-Heydemann-Str. 6, 18057, Rostock

    Volker Kiefel

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Bux, J., Sachs, U. (2010). Therapie mit Granulozyten. In: Kiefel, V., Mueller-Eckhardt, C. (eds) Transfusionsmedizin und Immunhämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12765-6_23

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  • DOI: https://doi.org/10.1007/978-3-642-12765-6_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12764-9

  • Online ISBN: 978-3-642-12765-6

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