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Alloantigene auf Granulozyten

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Transfusionsmedizin und Immunhämatologie

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Zusammenfassung

Die bekanntesten polymorphen und immunogenen Strukturen auf der Zellmembran von Leukozyten sind die Antigene des HLA-Systems. Darüber hinaus konnten auf Granulozyten zahlreiche antigene Strukturen biochemisch, molekularbiologisch und funktionell charakterisiert werden. Zur besseren Systematisierung wurde für diese die HNA-Nomenklatur (humane neutrophile Alloantigene), eingeführt und die Antigene entsprechend neu benannt. Den HNA-Antigenen kommt eine wichtige Rolle bei der Induktion von Allo- und Autoantikörpern zu, die zu schwerwiegenden Immunneutropenien und lebensbedrohlichen Transfusionsreaktionen führen können.

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  1. DRK-Blutspendedienst West gemeinnützige GmbH, Feithstr. 182, 58097, Hagen

    Prof. Dr. J. Bux

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  1. Abteilung für Transfusionsmedizin, Universitätsklinikum Rostock AöR, Ernst-Heydemann-Str. 6, 18057, Rostock

    Volker Kiefel

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Bux, J. (2010). Alloantigene auf Granulozyten. In: Kiefel, V., Mueller-Eckhardt, C. (eds) Transfusionsmedizin und Immunhämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12765-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-12765-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12764-9

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