Skip to main content
SpringerLink
Log in

Strahlentherapie

  • Chapter
Mammakarzinom Interdisziplinär

  • 2522 Accesses

Zusamenfassung

Primäres Ziel der Lokaltherapie des Mammakarzinoms, insbesondere in den frühen Stadien, muss es sein, den Tumor komplett zu entfernen und das Risiko eines Rezidivs in der Brust, an der Brustwand oder den Lymphabflusswegen zu minimieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 79.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Antonini N, Jones H, Horiot JC et al. (2007) Effect of age and radiation dose on local control after breast conserving treatment: EORTC Trial 22881–10882. Radiother Oncol 82: 265–271

    Article  PubMed  Google Scholar 

  • Bartelink H, Horiot JC, Poortmans P, et al. (2001) Recurrence rates after treatment of breast cancer with standard radiotherapyy with or without additional radiation. N Engl J Med 345: 1378–1387

    Article  CAS  PubMed  Google Scholar 

  • Bellon JR, Harris JR (2005) Chemotherapy and radiation therapy for breast cancer: What is the optimal sequence ? J Clin Oncol 23: 5–7

    Article  CAS  PubMed  Google Scholar 

  • Bijker N, Meijnen p Peterse JL et al. (2006) Breast conserving treatment with or without radiotherapy in ductal-carcinoma-in-situ: ten-year results of EORTC randomised phase III trial 10853. J Clin Oncol 24: 3381–3387

    Article  PubMed  Google Scholar 

  • Buchholz TA, Haffty BG (2008) Breast cancer: Locally advanced and recurrent disease, postmastectomy radiation, and systemic therapies. In: Halperin C, Perez CA, Brady LW (eds) Perez and Brady’s principles and practice of radiation oncology. 5th ed. Lippincott, Williams & Wilkins, Philadelphia, pp 1292–1317

    Google Scholar 

  • Buchholz TA, Lehman CD, Harris JR et al. (2008) Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: A national cancer institute conference. J Clin Oncol 26: 791–797

    Article  PubMed  Google Scholar 

  • Chen RC, Lin NU, Golshan M et al. (2008) Internal mammary nodes in breast cancer: Diagnosis and implications for patient management — A systemic review. J Clin Oncol 26: 4981–4988

    Article  PubMed  Google Scholar 

  • Darby SC, McGale P, Taylor CW et al. (2005) Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300000 women in USS SEER cancer registries. Lancet Oncol 6: 557–565

    Article  PubMed  Google Scholar 

  • Fisher B, Anderson S, Bryant J et al. (2002) Twenty-year follow-up of a randomised trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347: 1233–1241

    Article  PubMed  Google Scholar 

  • Fisher B, Brown A, Mamounas E et al. (1997) Effect of preoperative chemotherapy on loco-regional disease in women with operable breast cancer: Findings from NSABP-B-18. J Clin Oncol 15: 2483–2493

    CAS  PubMed  Google Scholar 

  • Fisher B, Dignam J, Wolmark N et al. (1998) Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: Findigs from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol 16: 441–452

    CAS  PubMed  Google Scholar 

  • Fisher B, Dignam J, Wolmark N et al. (1999) Tamoxifen in the treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-245 randomized controlled trial. Lancet 353: 1993–2000

    Article  CAS  PubMed  Google Scholar 

  • Fowble B, Solin LJ, Schultz DJ et al. (1991) Ten-years results of conservative surgery and radiation for stage I and II breast cancer. Int J Radiat Biol Phys 21: 269–277

    Article  CAS  Google Scholar 

  • Fyles AW, McCready DR, Manchul LA et al. (2004) Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 351: 963–970

    Article  CAS  PubMed  Google Scholar 

  • Gebski V, Lagleva M, Keech A (2006) Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspective. J Natl Cancer Inst 98: 26–38

    Article  PubMed  Google Scholar 

  • Giordano SH, Kuo YF, Freeman JL et al. (2005) Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl cancer Inst 97: 419–424

    Article  PubMed  Google Scholar 

  • Haffty BG, Buch holz TA, Perez CA (2008) Early stage breast cancer. In: Halperin C, Perez CA, Brady LW (eds) Perez and Brady’s principles and practice of radiation oncology. Fifth edition. Lippincott, Williams &Wilkins, Philadelphia, pp 1175–1291

    Google Scholar 

  • Harris EE, Hwang WT, Fox K et al. (2005) Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conserving treatment. J Clin Oncol 23: 11–16

    Article  CAS  PubMed  Google Scholar 

  • Holland R, Veling SHJ, Mravunac M et al. (1985) Histologic multifocality of Tis, T1-2 breast carcinomas: implications for clinical trials of breast-conserving surgery. Cancer 56: 979–990

    Article  CAS  PubMed  Google Scholar 

  • Hooning MJ, Aleman BM, Hauptmann M et al. (2008) Role of radiotherapy and chemotherapy in the development of contra lateral breast cancer. J Clin Oncol 26: 5561–5568

    Article  PubMed  Google Scholar 

  • Houghton J, George WD, Cuzick J et al. (2003) Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia and New Zealand: Randomized controlled trial. Lancet 362: 95–102

    Article  PubMed  Google Scholar 

  • Huang EH, Strom EA, Perkins GH et al. (2006) Comparison of risk of local-regional recurrence after mastectomy or breast-conservation therapy for patients treated with neoadjuvant chemotherapy and radiation stratified according to a prognostic index-score. Int J Radiat Oncol Biolk Phys 352–357

    Google Scholar 

  • Hughes KS, Schnaper LA, berry D, et al. (2004) Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 351: 971–977

    Article  CAS  PubMed  Google Scholar 

  • Hurkmans CW, Borger JH, Rutjers EJ et al. (2003) Quality assurance of axillary radiotherapy in the EORTC AMAROS trial 10981/22023: the dummy run. Radiother Oncol 68: 233–240

    Article  PubMed  Google Scholar 

  • Jagsi R, Pierce L (2009) Postmastectomy radiation therapy for patients with locally advanced breast cancer. Semin Radiat Oncol 19: 236–243

    Article  PubMed  Google Scholar 

  • Kunkler IH, Canney P, van Tienhoven G et al. (2008) Elucidating the role of chest wall irradiation in «intermediate-risk« breast cancer: the MRC/EORTC SUPREMO trial. Clin Oncol 20: 31–34

    Article  CAS  Google Scholar 

  • Kurtz JM, Jaquemier J, Amalric R et al. (1991) Breast conserving therapy for macroscopically multiple cancers. Ann Surg 212: 38–44

    Article  Google Scholar 

  • Lingos TI, Recht A, Vincini F et al. (1991) Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys 21: 355–360

    Article  CAS  PubMed  Google Scholar 

  • Lohr, F, Heggemann F, Papavassiliu T, et al. (2009) Ist die Kardiotoxizität der Radiotherapie im Rahmen des Brusterhalts überhaupt noch relevant, und könnte sie durch Mehrfelder-IMRT gesenkt werden? Strahlenther Onkol 185: 222–230

    Article  PubMed  Google Scholar 

  • Mannino M, Yarnold JR (2009) Local relapse rates are falling after breast conserving surgery and systemic therapy for early breast cancer: Can radiotherapy ever be safely withheld? Radiother Oncol 90: 14–22

    Article  PubMed  Google Scholar 

  • Mauri D, Pavlidis N, Ioannidis JP (2005) Neoadjuvant versus adjuvant systemic treatment in breast cancer. A meta-analysis. J Natl Cancer Inst 97: 188–194

    Article  PubMed  Google Scholar 

  • Moran MS, Haffty BG (2009) Radiation techniques and toxicities for locally advanced breast cancer. Semin Radiat Oncol 19: 244–255

    Article  PubMed  Google Scholar 

  • Ott OJ, Hildebrandt G, Pötter R et al. (2007) Accelerated partialbreast irradiation with multi-catheter brachytherapy: local control, side effects and cosmetic outcome for 274 patients. Results of the German-Austrian multi-centre trial. Radiother Onkol 82: 281–286

    Article  Google Scholar 

  • Overgaard M, Hansen P, Overgaard J et al. (1997) Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl Med 337: 949–955

    Article  CAS  Google Scholar 

  • Overgaard M, Jensen M-B, Overgaard J et al. (1999) Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant ramoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353: 1641–1648

    Article  CAS  PubMed  Google Scholar 

  • Overgaard M, Nielsen HM, Overgaard J (2007) Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82b et c randomised trials. Radiother Oncol 82: 247–253

    Article  PubMed  Google Scholar 

  • Park CC, Mitsumori M, Nixon A et al. (2000) Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol 18: 1668–1675

    CAS  PubMed  Google Scholar 

  • Pignol JP, Olivotto I, Rakovitch E et al. (2009) A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 26: 2085–2092

    Article  Google Scholar 

  • Poortmans P (2007) Evidence based radiation oncology: Breast cancer. Radiother Oncol 84: 84–101

    Article  PubMed  Google Scholar 

  • Poortmans P, Collette L, Bartelink H et al. (2008) The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881/10882 «boost versus no boost« trial. Cancer Radiother 12: 565–570

    CAS  PubMed  Google Scholar 

  • Poortmans P, Collette L, Horiot JC. (2009) Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breats cancer after microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial. Radiother Oncol 90: 80–85

    Article  PubMed  Google Scholar 

  • Ragaz J, Jackson S, Le N et al. (1997) Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 337: 956–962

    Article  CAS  PubMed  Google Scholar 

  • Recht A, Edge SB, Solin LJ et al. (2001) Postmastectomy radiotherapy: Clin practice guidelines of the ASCO. J Clin Oncol 19: 1539–1569

    CAS  PubMed  Google Scholar 

  • Recht A (2003) Integration of systemic therapy and radiation therapy for patients with early-stage breast cancer treated with conservative surgery. A comprehensive review. Clin Breast Cancer 4: 104–113

    Article  PubMed  Google Scholar 

  • Romestaing P, Ecochard R, Hennequin C et al. (2000) The role of internal mammary chain irradiation on survival after mastectomy for breast cancer. Results of a phase III SFRO trial. Radiother Oncol 56 (abstract 306)

    Google Scholar 

  • Rowell NP (2009) Radiotherapy to the chest wall following mastectomy for node-negative breast cancer: A systemic review. Radiother Oncol 91: 23–32

    Article  PubMed  Google Scholar 

  • Rutqvist LE, Lax I, Fornander T et al. (1992) Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer. Int J Radiat Oncol Biol Phys 22: 887–896

    Article  CAS  PubMed  Google Scholar 

  • Sator CI, Peterson BL, Woolf S et al. (2005) Effect of addition of adjuvant paclitaxel on radiotherapy delivery an locoregional control of node-positive breast cancer: CALG B 9344. J Clin Oncol 23: 30–40

    Article  Google Scholar 

  • Sauer R, Sauer G (2009) Mamma. In: Bamberg M, Molls M, Sack H (Hrsg) Radioonkologie: Band 2, Klinik, 2. Aufl. Zuckschwerdt, München, S., 647–689

    Google Scholar 

  • Sautter-Bihl M-L, Budach W, Dunst J et al. (2007) DEGRO practical guidelines for radiotherapy of breast cancer I. Strahlenther Onkol 183: 661–666

    Article  PubMed  Google Scholar 

  • Sautter-Bihl M-L, Souchon R, Budach W et al (2008) DEGRO practical guidelines for radiotherapy of breast cancer II. Strahlenther Onkol 184: 347–353

    Article  PubMed  Google Scholar 

  • Schlembach PJ, Buchholz TA, Ross MI et al. (2001) Relationship of sentinel and axillary lev I-II lymph nodes to tangential fields used in breast irradiation. Int J Radiat Oncol Biol Phys 51: 671–678

    Article  CAS  PubMed  Google Scholar 

  • Schmidberger H, Hermann RM, Hess CF et al. (2003) Interactions between radiation and endocrine therapy in breast cancer. Endocr Relat Cancer 10: 375–388

    Article  CAS  PubMed  Google Scholar 

  • Solin LJ (1993) Regional lymph node management in conservation treatment of early stage invasive breast carcinoma. Int J Radiat Oncol Biol Phys 26: 709–710

    Article  CAS  PubMed  Google Scholar 

  • Solin LJ, Fourquet A, Vicini FA et al. (2001) Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammogaphically detected ductal carcinama in-situ of the breast. Cancer 91: 1090–1097

    Article  CAS  PubMed  Google Scholar 

  • Solin LJ, Fourquet A, Vicini FA et al. (2005) Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in-situ of the breast. Cancer 103: 1137–1146

    Article  PubMed  Google Scholar 

  • Specht J, Gralow JR (2009) Neoadjuvant chemotherapy for locally advanced breast cancer. Semin Radiat Oncol 19: 222–228

    Article  PubMed  Google Scholar 

  • Tubiana M (2009) Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review. Radiother Oncol 91: 4–15

    Article  Google Scholar 

  • Van den Bogaert W, Struikmans H, Fourquet A, et al. (1996) Internal mammary and supraclavicular (IM-MS) lymph node chain irradiation in stage I-III breast cancer. A phase III randomized trial of the EORTC, protocol 22922/10925

    Google Scholar 

  • Van der Hage JA, Cornelis JH, van de Velde CJ et al. (2001) Properative chemotherapy in primary operable Breast cancer: Results from the EORTC trial 10902. J Clin Oncol 19: 4224–4237

    PubMed  Google Scholar 

  • Van de Steene J, Vinh-Hung V, Cutuli B et al. (2004) Adjuvant radiotherapy for breast cancer: effects of longer follow-up. Radiother Oncol 72: 35–43

    Article  PubMed  Google Scholar 

  • Veronesi U, Marubini E, Mariani L et al. (2002) Twenty-year follow-up of a randomized study comparing breast conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347: 1227–1232

    Article  PubMed  Google Scholar 

  • Vicini F, Beitsch PD, Quiet CA et al. (2008) Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons Mammo Site Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer 112: 758–766

    Article  PubMed  Google Scholar 

  • Vrieling C, Collette L, Fourquet, A et al. (1999) The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC «boost versus no boost« trial. Int J Radiat Oncol Biol Phys 45: 677–685

    Article  CAS  PubMed  Google Scholar 

  • Whelan TJ, Julian J, Wright J et al. (2000) Does locoregional radiation therapy improve survival in breast cancer? J Clin Oncol 18: 1220–1229

    CAS  PubMed  Google Scholar 

  • Wolmark N, Wang J, Mamounas E et al (2001) Preoperative chemotherapy in patients with operable breast cancer. Cancer 30: 96–102

    Google Scholar 

  • Wong JS, Kaelin CM, Troyan SL et al. (2006) Prospective study of wide excision alone for ductal carcinoma in situ of th breast. J Clin Oncol 24: 1031–1036

    Article  PubMed  Google Scholar 

  • Woodward WA, Buchholz TA (2008) The role of locoregional therapy in inflammatory breast cancer. Sem Oncol 35: 78–86

    Article  Google Scholar 

Literatur

  • Albrecht MR, Zink K, Busch W, Rühl U (2002) Dissection or irradiation of the axilla in postmenopausal patients with breast cancer? Long-term results and late effects in 655 patients. Strahlenther Onkol 178: 510–516

    Article  PubMed  Google Scholar 

  • Arthur D (2003) Accelerated partial breast irradiation: a change in treatment paradigm for early stage breast cancer. J Surg Oncol 84: 185–191

    Article  PubMed  Google Scholar 

  • Bartelink H (2003) Radiotherapy to the conserved breast, chest wall, and regional nodes: is there a standard? Breast 6: 475–482

    Article  Google Scholar 

  • Bartelink H, Horiot JC, Poortmanns P et al. (2001) Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 345: 1378–1387

    Article  CAS  PubMed  Google Scholar 

  • Bijker N, Peterse JL, Duchateau L et al. (2001) Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: Analysis of EORTC-Trial 10853. J Clin Oncol 19: 2263–2271

    CAS  PubMed  Google Scholar 

  • Boyages J, Delaney G, Taylor R (1999) Predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis. Cancer 85: 616–628

    Article  CAS  PubMed  Google Scholar 

  • Buchholz TA, Strom EA et al. (2002) Pathologic tumor size and lymph node status predict for different rates of loco regional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapy. Int J Radiat Oncol Bio Phys 53: 880–888

    Article  Google Scholar 

  • Buchholz TA, Strom EA, McNeese MD et al. (2003) Radiation therapy as an adjuvant treatment after sentinel lymph node surgery for breast cancer. Surg Clin North Am 83: 911–930

    Article  PubMed  Google Scholar 

  • Fisher B, Bryant J, Dignam JJ et al. (2002a) Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol 20: 4141–4149

    Article  CAS  PubMed  Google Scholar 

  • Fisher B, Anderson S, Bryant J et al. (2002b) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347: 1233–1241

    Article  PubMed  Google Scholar 

  • Fisher B, Land S, Mamounas E et al. (2001) Prevention of invasive breast cancer in women with ductal carcinoma in situ: An update of the national surgical adjuvant breast and bowel experience. Semin Oncol 28: 400–418

    Article  CAS  PubMed  Google Scholar 

  • Harris JR, Halpin-Murphy P, McNeese M et al. (1999) Consensus statement on postmastectomy radiation therapy. Int J Radiat Oncol Bio Phys 44: 989–990

    Article  CAS  Google Scholar 

  • Houghton J, George WD, Cuzick J et al., UK Coordinating Committee on Cancer Research; Ductal Carcinoma in situ Working Party; DCIS trialists in the UK, Australia, and New Zealand (2003) Radiotherapy and tamoxifen in women completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial. Lancet 362: 95–102

    Google Scholar 

  • Hurkmans CW, Cho BC, Damen E et al. (2002) Reduction of cardiac and lung complication probabilities after breast irradiation using conformal radiotherapy with or without intensity modulation. Radiother Oncol 62: 173–171

    Article  Google Scholar 

  • Kraus-Tiefenbacher U, Bauer L, Kehrer T et al. (2006) Intraoperative radiotherapy (IORT) as a Boost in patients with early-stage breast cancer — acute toxicity. Onkologie 29: 77–82

    Article  PubMed  Google Scholar 

  • Kraus-Tiefen bacher U, Bauer L, Scheda A et al. (2006) Long-term toxicity of an intraoperative radiotherapy boost using low energy x-rays during breast conserving surgery. Int J Radiat Oncol Biol Phys 66(2): 377–381

    Article  Google Scholar 

  • Kraus-Tiefen bacher U, Welzel G, Brade J et al. (2009) Postoperative seroma formation after intraoperative radiotherapy (IORT) using low KV x-rays given during breast conserving surgery. Int J Radiat Oncol Biol Phys [epub ahead of print]

    Google Scholar 

  • Kreienberg R et al. (2003) S3-Leitlinie Mammakarzinom. Deutsche Krebsgesellschaft e.V., Berlin

    Google Scholar 

  • Kuerer HM, Julian TB, Strom EA et al. (2004) Accelerated partial breast irradiation after conservative surgery for breast cancer. Ann Surg 239: 338–351

    Article  PubMed  Google Scholar 

  • Louis-Sylvestre C, Clough K, Asselain B et al. (2004) Axillary treatment in conservative management of operable breast cancer: dissection or radiotherapy? Results of a randomized study with 15 years of follow-up. J Clin Oncol 22: 97–101

    Article  PubMed  Google Scholar 

  • Malmstrom P, Holmberg L, Anderson H et al. (2003) Breast conserving surgery, with or without radiotherapy, in woman with nodenegative breast cancer: randomized clinical trial in a population with access to public mammography screening. Eur J Cancer 39: 1690–1697

    Article  CAS  PubMed  Google Scholar 

  • Muren LP, Maurstad G, Hafslund R et al. (2002) Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. Radiother Oncol 62: 173–183

    Article  PubMed  Google Scholar 

  • Recht A (2003) Integration of systemic therapy and radiation therapy for patients with early-stage breast cancer treated with conservative surgery. Clin Breast Cancer 4: 104–113

    Article  PubMed  Google Scholar 

  • Recht A, Edge SB, Solin LJ et al. (2001) Postmastectomy radiotherapy: Clinical practice guidelines of the ASCO. J Clin Oncol 19: 1539–1569

    CAS  PubMed  Google Scholar 

  • Rutqvist LE, Rose C, Cavallin-Stahl E (2003) A systematic overview of radiation therapy effects in breast cancer. Acta Oncologica 42: 532–545

    Article  PubMed  Google Scholar 

  • Sauer R, Schulz KD, Hellriegel K-P (2001) Strahlentherapie nach Mastektomie — Interdisziplinärer Konsensus beendet Kontroverse. Strahlenther Onkol 177: 1–9

    Article  CAS  PubMed  Google Scholar 

  • Sedlmayer F, Fastner G, Merz F et al. (2007) IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: results of an ISIORT pooled analysis. Strahlenther Onkol 183 Spec No 2: 32–34

    Article  PubMed  Google Scholar 

  • Silverstein M (2002) The USC/Van Nuys Prognostic Index. Ductal Carcinoma in Situ of the Breast. Philadelphia, Lipincott, Wiliams and Wilkins; pp 459–473

    Google Scholar 

  • Solin LJ, Fourquet A, Vicini F et al. (2001) Mammographically detected ductal carcinoma in situ of the breast treated with breast-conserving surgery and definitive breast irradiation: Long term outcome and prognostic significance of patient age and marginal status. Int J Radiat Oncol Biol Phys 50: 991–1002

    Article  CAS  PubMed  Google Scholar 

  • Vaidya JS, Baum M, Tobias JS et al. (2006) Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost. Int J Radiat Oncol Biol Phys 66(5): 1335–1338

    Article  PubMed  Google Scholar 

  • Veronesi U, Cascinelli N, Mariani L et al. (2003) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347: 1227–1232

    Article  Google Scholar 

  • Vinh-Hung V, Verschraegen C (2004) Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst 96: 88–89

    Article  Google Scholar 

  • Vrieling C, Collette L, Fourquet A et al. (2003) Can patient-, treatment-and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients. Eur J Cancer 39: 932–944

    Article  CAS  PubMed  Google Scholar 

  • Wenz F, Welzel G, Blank E et al. (2009) Intraoperative radiotherapy (IORT) as a boost during breast conserving surgery (BCS) using low kV X-rays — the first five years of experience with a novel approach. Int J Radiat Oncol Biol Phys [epub ahead of print]

    Google Scholar 

  • Whelan TJ, Julian T, Wright J et al. (2000) Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 18: 1220–1229

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie, Universität Köln, Kerpener Straße 62, 50937, Köln

    Prof. Dr.med. Rolf-Peter Müller & Dr.med. Rudolf Bongartz

  2. Universitätsklinik für Strahlentherapie und Radioonkologie Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim

    Prof. Dr.med. Frederik Wenz

Authors
  1. Prof. Dr.med. Rolf-Peter Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr.med. Rudolf Bongartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr.med. Frederik Wenz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg New York

About this chapter

Cite this chapter

Müller, RP., Bongartz, R., Wenz, F. (2010). Strahlentherapie. In: Mammakarzinom Interdisziplinär. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12681-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-12681-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12680-2

  • Online ISBN: 978-3-642-12681-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation