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Enantioselective Properties of Nucleic Acid Aptamer Molecular Recognition Elements

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Chiral Recognition in Separation Methods

Abstract

Target-specific chiral selectors, which are characterized by a predictable elution order depending on the target enantiomer employed for the selection of the chiral selector, have recently received much attention in the enantioselective analysis field. In this context, bioaffinity-based molecular recognition tools such as nucleic acid aptamers have notably demonstrated very attractive features for the chiral discrimination of active molecules. In this chapter, the enantioselective properties of aptamer chiral selectors and the major factors that control and modulate the liquid chromatography and capillary electrophoresis enantiomer separation are addressed.

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Authors and Affiliations

  1. Département de Pharmacochimie Moléculaire UMR 5063 CNRS, Institut de Chimie Moléculaire de Grenoble FR 2607, Université de Grenoble I, Bât E (C) André Rassat, Domaine Universitaire, 301 avenue de la Chimie, BP 53, 38041, Grenoble Cédex 9, France

    Eric Peyrin

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  1. Eric Peyrin
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Correspondence to Eric Peyrin .

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  1. , CNRS UMR 5180, University of Lyon, Villeurbanne Cédex, 69622, France

    Alain Berthod

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Peyrin, E. (2010). Enantioselective Properties of Nucleic Acid Aptamer Molecular Recognition Elements. In: Berthod, A. (eds) Chiral Recognition in Separation Methods. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12445-7_10

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