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Chiral Recognition in Separation Methods pp 1–32Cite as

Chiral Recognition Mechanisms in Enantiomers Separations: A General View

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Abstract

In 1858, Louis Pasteur, the first to accomplish the separation of two enantiomers wrote: “Most natural organic products, the essential products of life, are asymmetric and possess such asymmetry that they are not superimposable on their image. This establishes perhaps the only well-marked line of demarcation that can at present be drawn between the chemistry of dead matter and the chemistry of living matter.” Enantiomers have exactly the same properties in isotropic conditions. They behave differently only in anisotropic conditions. Chiral–chiral interactions are needed for enantiomeric separations. The fundamental mechanisms for chiral separations are listed along with the commercially available chiral selectors. Two chemometric examples are commented: one on quantitative structure enantioselectivity relationship and the second one on linear solvation energy relationships. It is shown that the solvents used in the mobile phase may play the most critical role in the chiral mechanism.

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  1. Laboratoire des Sciences Analytiques, Université de Lyon, CNRS, Bat. CPE, 69622, Villeurbanne, France

    Alain Berthod

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  1. Alain Berthod
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Correspondence to Alain Berthod .

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  1. , CNRS UMR 5180, University of Lyon, Villeurbanne Cédex, 69622, France

    Alain Berthod

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Berthod, A. (2010). Chiral Recognition Mechanisms in Enantiomers Separations: A General View. In: Berthod, A. (eds) Chiral Recognition in Separation Methods. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12445-7_1

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