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Der Stammzellmarker LgR5 wird in einer Subpopulation proliferierender (Ki-67 pos.) Zellen im Barrett-Ösophagus sowie Barrett-assoziierter Adenokarzinome exprimiert

The Stem Cell Marker LgR5 is Expressed in a Subpopulation of (Ki-67+) Cells in Barrett’s Esophagus and Barrett’s-Associated Adenocarcinomas

  • Conference paper
Chirurgisches Forum und DGAV Forum 2010

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 39))

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Abstract

Barrett’s esophagus (BE) is regarded as precancerous lesion of esophageal adenocarcinomas (EAC), arising in the distal esophagus, due to the chronically damaging effect of gastroesophageal reflux. However, not all EAC are associated with BE, and the exact cellular origin remains unknown. Similar to other solid tumors, a cancer stem cell (CSC) hypothesis has been suggested. Expression of the intestinal stem cell marker LgR5 was investigated in a series (n = 70) of esophageal carcinomas. LgR5 expression was found in EAC with and without BE, but not in esophageal SCC. A subpopulation of proliferating Lgr5+ cells (<5 %) might comprise the rapidly proliferating stem cell compartiment, or postmitotic dedifferentiated cells, which requires further investigation.

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Author information

Authors and Affiliations

  1. Klinik fur Allgemein., Viszeral., Gefas-, und Kinderchirurgie, Zentrum für operative Medizin (ZOM), Oberdürrbacherstr. 6, 97080, Würzburg

    Priv.-Doz. Dr. med. H. Burkhard, A. von Rahden, L. Stürmer, C. Reiber, M. Lazariotou, C.-T. Germer & M. Grimm

  2. Institut für Pathologie, Universität Würzburg, München

    S. Kircher & S. Gattenlöhner

Authors
  1. Priv.-Doz. Dr. med. H. Burkhard
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  2. A. von Rahden
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  3. L. Stürmer
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  4. C. Reiber
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  5. M. Lazariotou
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  6. S. Kircher
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  7. S. Gattenlöhner
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  8. C.-T. Germer
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  9. M. Grimm
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Editor information

Editors and Affiliations

  1. Klinik für Orthopädie und Unfallchirurgie, Klinikum rechts der Isar TUM, Ismaninger Str. 22, 81675, München

    R. Gradinger (Direktor) (Direktor)

  2. Instituts für Klinisch-Experimentelle Chirurgie, Universität des Saarlandes, 66421, Homburg/Saar

    M.D. Menger (Direktor) (Direktor)

  3. Abt. Allgemeine Viszeralchirurgie, Städtisches Klinikum Solingen, Gotenstr. 1, 42653, Solingen

    H.-J. Meyer (Präsident der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie) (Präsident der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie)

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Burkhard, H. et al. (2010). Der Stammzellmarker LgR5 wird in einer Subpopulation proliferierender (Ki-67 pos.) Zellen im Barrett-Ösophagus sowie Barrett-assoziierter Adenokarzinome exprimiert. In: Gradinger, R., Menger, M., Meyer, HJ. (eds) Chirurgisches Forum und DGAV Forum 2010. Deutsche Gesellschaft für Chirurgie, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12192-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-12192-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12191-3

  • Online ISBN: 978-3-642-12192-0

  • eBook Packages: Medicine (German Language)

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