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Sambucus Ribosome-Inactivating Proteins and Lectins

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Toxic Plant Proteins

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 18))

Abstract

Plant ribosome-inactivating proteins (RIPs) are inhibitors with RNA-N-glycosidase activity that irreversibly inactivate eukaryotic ribosomes, thereby impairing protein synthesis. In recent years, more than 40 RIPs and lectins belonging to the Sambucus genus have been isolated and characterized to varying degrees. The type 2 RIPs isolated from Sambucus have the peculiarity that although they are enzymatically more active than ricin, they lack the high toxicity of ricin to intact cells and animals. The presence in the same tissue of heterodimeric and tetrameric type 2 RIPs, structurally related monomeric, and homodimeric lectins together with unrelated type 1 RIPs make Sambucus an ideal model for studying these special proteins whose biological role is unknown at present. In the light of the accumulated results on the Sambucus RIPs and lectins, we present here the main findings about structural features and biological activities of these proteins as well as the evolutionary relationship between them and some of their potential uses.

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Acknowledgments

This work was supported by grants from the Junta de Castilla y León (VA0150A7, GR106 and Consejería de Sanidad) and UVA-GIR funding to T.G and FISPI04/1279 to J.M.F. We thank Judy Callaghan for correcting the manuscript.

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Valladolid, E-47005, Valladolid, Spain

    José Miguel Ferreras, Lucía Citores & Rosario Iglesias

  2. Nutrición y Bromatología, Facultad de Medicina and CINAD, Universidad de Valladolid, E-47005, Valladolid, Spain

    Pilar Jiménez & Tomás Girbés

Authors
  1. José Miguel Ferreras
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  2. Lucía Citores
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  3. Rosario Iglesias
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  4. Pilar Jiménez
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  5. Tomás Girbés
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Corresponding author

Correspondence to Tomás Girbés .

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Editors and Affiliations

  1. Dept. Biological Sciences, University of Warwick, Coventry, CV47AL, United Kingdom

    J. Michael Lord

  2. Dept. Biological Sciences, University of Warwick, Coventry, CV47AL, United Kingdom

    Martin R. Hartley

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Ferreras, J.M., Citores, L., Iglesias, R., Jiménez, P., Girbés, T. (2010). Sambucus Ribosome-Inactivating Proteins and Lectins. In: Lord, J., Hartley, M. (eds) Toxic Plant Proteins. Plant Cell Monographs, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12176-0_6

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