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Mould Infections: A Global Threat to Immunocompromised Patients

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Combating Fungal Infections

Abstract

The increase in critical care and immunosuppressed patients all over the world during recent decades is due to a general medical concern with regard to fungal infections, particularly regarding patients admitted at intensive care, haematological, stem cell and solid organ transplant and burn units. The wide use of intense suppressive therapies which affect patients’ immune status and frequently cause neutropenia represents an enormous risk of mould infections. Aspergillus, Fusarium, Scedosporium, and zygomycetes, particularly Rhizopus and Mucor, are invariably responsible for high morbidity and mortality in patients, even after the administration of proper antifungal therapy. These infections are often associated with longer stays in critical care units and extremely high healthcare costs. Other therapeutic drugs administered to high-risk patients may considerably promote or reduce the fungal growth and affect the development of the invasive disease. Thus, it is recommended that drug interactions be taken into account in patients receiving multiple medications.

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Authors and Affiliations

  1. IPATIMUP, Institute of Pathology and Molecular Immunology, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal

    Ricardo Araujo

  2. Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal

    Ricardo Araujo, Cidália Pina-Vaz & Acácio Gonçalves Rodrigues

  3. Burn Unit, Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Porto and Hospital S. João, Porto, Portugal

    Acácio Gonçalves Rodrigues

Authors
  1. Ricardo Araujo
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  2. Cidália Pina-Vaz
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  3. Acácio Gonçalves Rodrigues
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Corresponding author

Correspondence to Ricardo Araujo .

Editor information

Editors and Affiliations

  1. Fac. Agricultural Sciences, Dept. Agricultural Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Iqbal Ahmad

  2. Dept. Biochemistry, Interdiciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202 002, India

    Mohammad Owais

  3. J. N. Medical College, Dept. Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Mohammed Shahid

  4. James Graham Brown Cancer Center, S. Preston Street 580, Louisville, 40202, USA

    Farrukh Aqil

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Araujo, R., Pina-Vaz, C., Rodrigues, A.G. (2010). Mould Infections: A Global Threat to Immunocompromised Patients. In: Ahmad, I., Owais, M., Shahid, M., Aqil, F. (eds) Combating Fungal Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12173-9_1

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