Abstract
CyberKnife® (CK) robotic stereotactic body radiotherapy (SBRT) is a noninvasive method to deliver radiation dose distributions that very closely resemble those delivered by high-dose-rate (HDR) brachytherapy. We have applied “Virtual HDR” CK SBRT as an “HDR surrogate,” using comparable dose fractionation schedules in all settings where HDR brachytherapy has been applied, including as monotherapy for favorable to intermediate-risk cases, as a boost for high risk cases and as a salvage method for post-radiotherapeutic relapse cases.
Clinical results are encouraging in all three settings, suggesting at least comparable safety and efficacy. Our Virtual HDR CyberKnife monotherapy pilot series to test the equivalence to HDR brachytherapy and other methods of radiation delivery continues, as does a significantly larger multi-institutional series, to confirm our pilot series findings in a larger number of patients, treated across a wider variety of CyberKnife practices.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Grills IS, Martinez AA, Hollander M et al (2004) High dose rate brachytherapy as prostate cancer monotherapy reduces toxicity compared to low dose rate palladium seeds. J Urol 171:1098–1104
Demanes DJ, Rodriguez RR, Schour L et al (2005) High-dose-rate intensity-modulated brachytherapy with external beam radiotherapy for prostate cancer: California endocurietherapy’s 10-year results. Int J Radiat Oncol Biol Phys 61:1306–1316
Mate TP, Gottesman JE, Hatton J et al (1998) High dose-rate afterloading 192Iridium prostate brachytherapy: feasibility report. Int J Radiat Oncol Biol Phys 41:525–533
Vargas CE, Martinez AA, Boike TP et al (2006) High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: results of a phase I to II study. Int J Radiat Oncol Biol Phys 66:416–423
McNeal JE, Redwine EA, Freiha FS et al (1988) Zonal distribution of prostatic adenocarcinoma. Correlation with histologic pattern and direction of spread. Am J Surg Pathol 12:897–906
Williams SG, Taylor JM, Liu N et al (2007) Use of individual fraction size data from 3756 patients to directly determine the alpha/beta ratio of prostate cancer. Int J Radiat Oncol Biol Phys 68:24–33
King CR, Lehmann J, Adler JR et al (2003) CyberKnife radiotherapy for localized prostate cancer: rationale and technical feasibility. Technol Cancer Res Treat 2:25–30
Demanes D, Altieri G, Barnaba M et al (2006) High dose rate (HDR) monotherapy is equivalent to combined HDR brachytherapy and external beam radiation therapy (EBRT) for early prostate cancer. Int J Radiat Oncol Biol Phys 66:S351
Fuller DB, Naitoh J, Lee C et al (2008) Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations. Int J Radiat Oncol Biol Phys 70:1588–1597
Aluwini S, van Rooij P, Hoogeman M et al (2010) CyberKnife stereotactic radiotherapy as monotherapy for low- to intermediate-stage prostate cancer: early experience, feasibility, and tolerance. J Endourol 24:865–869
Chang SD, Main W, Martin DP et al (2003) An analysis of the accuracy of the CyberKnife: a robotic frameless stereotactic radiosurgical system. Neurosurgery 52:140–146, discussion 146–147
Ho AK, Fu D, Cotrutz C et al (2007) A study of the accuracy of cyberknife spinal radiosurgery using skeletal structure tracking. Neurosurgery 60:ONS147–ONS156, discussion ONS156
Xie Y, Djajaputra D, King CR et al (2008) Intrafractional motion of the prostate during hypofractionated radiotherapy. Int J Radiat Oncol Biol Phys 72:236–246
Blasko JC, Grimm PD, Sylvester JE et al (2000) Palladium-103 brachytherapy for prostate carcinoma. Int J Radiat Oncol Biol Phys 46:839–850
Ray ME, Thames HD, Levy LB et al (2006) PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis. Int J Radiat Oncol Biol Phys 64:1140–1150
Caloglu M, Ciezki JP, Reddy CA et al (2011) PSA bounce and biochemical failure after brachytherapy for prostate cancer: a study of 820 patients with a minimum of 3 years of follow-Up. Int J Radiat Oncol Biol Phys 80(3):735–741, Epub 2010 Jun 18
Lee B, Shinohara K, Weinberg V et al (2007) Feasibility of high-dose-rate brachytherapy salvage for local prostate cancer recurrence after radiotherapy: the University of California-San Francisco experience. Int J Radiat Oncol Biol Phys 67:1106–1112
Fuller D, et al. Virtual HDR CyberKnife Radiosurgery for locally recurrent Prostatic Carcinoma: A phase II Study. http://clinicaltrials.gov/. Accessed Sept, 2011
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fuller, D.B. (2012). Virtual HDR® CyberKnife Treatment for Localized Prostatic Carcinoma: Principles and Clinical Update. In: Ponsky, L., Fuller, D., Meier, R., Ma, C. (eds) Robotic Radiosurgery. Treating Prostate Cancer and Related Genitourinary Applications. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11495-3_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-11495-3_14
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11494-6
Online ISBN: 978-3-642-11495-3
eBook Packages: MedicineMedicine (R0)