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The β-Lactam Antibiotics: Current Situation and Future Prospects in Manufacture and Therapy

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Industrial Applications

Part of the book series: The Mycota ((MYCOTA,volume 10))

Abstract

This chapter illustrates recent changes in the global scenery and market for β-lactam antibiotics during the past 10 years and gives a comprehensive overview of current developments and future trends in their manufacture and their prospects in antibiotic therapy. Every aspect of their manufacture is covered in the first part, starting from genetics, biosynthesis and strategies for improving strains and their fermentation and ending with downstream processing, including their cleavage to 6-aminopenicillanic acid and 7-aminocephalosporanic acid and the according approaches for a general process economization. The second part outlines the therapeutic implications and mechanisms of β-lactam resistance, presents current strategies to overcome them, compiles the most recently commercialized β-lactam drug developments and finally gives an outlook on novel therapeutic approaches.

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  1. Prozeßentwicklung Chemie, Sanofi-Aventis Deutschland GmbH, 65926, Frankfurt am Main, Germany

    Frank-Rainer Schmidt

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  1. Frank-Rainer Schmidt
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Correspondence to Frank-Rainer Schmidt .

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  1. , Department of Biotechnology, International Graduate School of Zittau, Markt 23, Zittau, 02763, Sachsen, Germany

    Martin Hofrichter

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Schmidt, FR. (2011). The β-Lactam Antibiotics: Current Situation and Future Prospects in Manufacture and Therapy. In: Hofrichter, M. (eds) Industrial Applications. The Mycota, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11458-8_5

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