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Biofilms

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Nasal Polyposis

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Abstract

Bacterial biofilms are three-dimensional aggregates of bacteria encased in secreted exopolysaccharides (slime) and lack vulnerability to antibiotics that planktonic bacteria demonstrate. Biofilm-forming bacteria are common. Bacterial biofilms may contribute to medically recalcitrant chronic rhinosinusitis (CRS). Tactics developed to treat planktonic bacteria are ineffective against bacteria in a biofilm – this helps explain a portion of the persistent and recurrent infections observed in CRS. Understanding how biofilm infections form is fundamental to developing rational strategies for the prevention and treatment of biofilm-associated CRS. New investigations into therapeutic remedies aimed at eradicating biofilm infections are ongoing and hold promise for alleviating individuals’ suffering from recurrent infections associated with CRS.

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Author information

Authors and Affiliations

  1. Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA

    Bradford A. Woodworth

  2. Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA

    James N. Palmer

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  1. Bradford A. Woodworth
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  2. James N. Palmer
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Correspondence to James N. Palmer .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Dept. of Otorhinolaryngology, Hacettepe University, Ankara, 06100, Turkey

    T. Metin Önerci

  2. School of Medicine, Dept. Otolaryngology, University of Pittsburgh, Locust Street 1400, Pittsburgh, 15219, USA

    Berrylin J. Ferguson

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© 2010 Springer-Verlag Berlin Heidelberg

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Woodworth, B.A., Palmer, J.N. (2010). Biofilms. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-11412-0_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11411-3

  • Online ISBN: 978-3-642-11412-0

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