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Current Concepts on the Pathomechanisms of Chronic Rhinosinusitis and Nasal Polyps

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Nasal Polyposis

Abstract

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airway subdivided into CRS with or without nasal polyps. CRS with or without nasal polyps is characterized by the infiltration of inflammatory cells, predominantly eosinophils or neutrophils and mast cells and T cells and inflammatory mediators, adhesion molecules, and matrix metalloproteinases. CRS without nasal polyps is more neutrophilic in nature, whereas CRS with nasal polyps especially when associated with aspirin sensitivity, asthma, or allergy is more often eosinophilic in nature. Remodeling like squamous metaplasia, basement membrane thickening, collagen deposition, hyperplasia of mucus glands and goblet cells are features found in both the subgroups of CRS.

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Author information

Authors and Affiliations

  1. Division of Rhinology and Allergy, Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, 113-8603, Japan

    Ruby Pawankar, Manabu Nonaka, Satoru Masuno & Satoko Kimura

Authors
  1. Ruby Pawankar
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  2. Manabu Nonaka
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  3. Satoru Masuno
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  4. Satoko Kimura
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Corresponding author

Correspondence to Ruby Pawankar .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Dept. of Otorhinolaryngology, Hacettepe University, Ankara, 06100, Turkey

    T. Metin Önerci

  2. School of Medicine, Dept. Otolaryngology, University of Pittsburgh, Locust Street 1400, Pittsburgh, 15219, USA

    Berrylin J. Ferguson

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Pawankar, R., Nonaka, M., Masuno, S., Kimura, S. (2010). Current Concepts on the Pathomechanisms of Chronic Rhinosinusitis and Nasal Polyps. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-11412-0_21

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11411-3

  • Online ISBN: 978-3-642-11412-0

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