Abstract
Systemic vasculitides, including Wegener’s granulomatosis and Churg-Strauss Syndrome, may be associated with nasal manifestations such as allergic and non-allergic rhinitis, chronic rhinosinusitis with and without nasal polyps. Management of systemic vasculitides require a multidisciplinary approach and is based on clinical, histopathological, and immunological features for the diagnosis, and on oral steroids and immunosuppressive agents for the treatment.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Amezcua-Guerra LM, Prieto P, Bojalil R et al (2006) Microscopic polyangiitis associated with primary biliary cirrhosis: a causal or casual association? J Rheumatol 33: 2351–2353
Boccagni C, Tesser F, Mittino D et al (2004) Churg–Strauss syndrome associated with the leukotriene antagonist montelukast. Neurol Sci 25:21–22
Churg J, Strauss L (1951) Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol 27:277–301
Cuchacovich R, Justiniano M, Espinoza LR (2007) Churg–Strauss syndrome associated with leukotriene receptor antagonists (LTRA). Clin Rheumatol 26:1769–1771
De Groot K, Rasmussen N, Bacon PA et al (2005) Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic anti-neutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 52:2461–2469
Devaney KO, Travis WD, Hoffman GS et al (1990) Interpretation of head and neck biopsies in Wegener’s granulomatosis. A pathologic study of 126 biopsies in 70 patients. Am J Surg Pathol 14:555–564
Ferri C, Zignego AL, Pileri SA (2002) Cryoglobulins. J Clin Pathol 55:4–13
Gencik M, Meller S, Borgmann S et al (2000) Proteinase 3 gene polymorphisms and Wegener’s granulomatosis. Kidney Int 58:2473–2477
Gross WL (2002) Churg–Strauss syndrome: update on recent developments. Curr Opin Rheumatol 14:11–14
Guillevin L, Lhote F (1998) Treatment of polyarteritis nodosa and microscopic polyangiitis. Arthritis Rheum 41: 2100–2105
Guillevin L, Lhote F, Gayraud M et al (1996) Prognostic factors in polyarteritis nodosa and Churg–Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 75:17–28
Hoffman GS, Kerr GS, Leavitt R et al (1992) Wegener’s granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488–498
Jayne D (2005) How to induce remission in primary systemic vasculitis. Best Pract Res Clin Rheumatol 19:293–305
Jayne D, Rasmussen N, Anfrassy K et al (2003) A randomized trial of maintenance therapy for vasculitis associated with anti-neutrophil cytoplasmic antibodies. N Engl J Med 349:36–44
Jennette JC, Falk RJ, Andrassy K et al (1994) Nomenclature of systemic vasculitis. Proposal of an international consensus conference. Arthritis Rheum 37:187–192
Keogh KA, Specks U (2003) Churg–Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. Am J Med 115:284–290
Langford CA (2001) Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg–Strauss syndrome: where do we stand? Arthritis Rheum 44:508–512
Langford CA, Sneller MC, Hallahan CW et al (1996) Clinical features and therapeutic management of subglottic stenosis in patients with Wegener’s granulomatosis. Arthritis Rheum 39:1754–1760
Lhote F, Cohen P, Guillevin L (1998) Polyarteritis nodosa, microscopic polyangiitis and Churg–Strauss syndrome. Lupus 7:238–258
Masi AT, Hunder GG, Lie JT et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg–Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–1100
Matteson EL (1998) Small-vessel vasculitis. N Engl J Med 338:994–995
Metaxaris G, Prokopakis EP, Karatzanis AD et al (2002) Otolaryngologic manifestations of small vessel vasculitis. Auris Nasus Larynx 29:353–356
Noth I, Strek ME, Leff AR (2003) Churg–Strauss syndrome. Lancet 361:587–594
Oristrell SJ, Bosch JA, Valdes OM et al (1985) Polyarteritis nodosa and perforation of the nasal septum. Med Clin (Barc) 84:673–674
Sansonno D, Damacco F (2005) Hepatitis C virus, cryoglobulinemia, and vasculitis: immune complex relations. Lancet Infect Dis 5:227–236
Seo P (2008) Wegener’s granulomatosis: managing more than inflammation. Curr Opin Rheumatol 20:10–16
Seo P, Stone JH (2004) The anti-neutrophil cytoplasmic antibody-associated vasculitides. Am J Med 117:39–50
Smith I, Smith M, Mathias D et al (1996) Cryoglobulinaemia and septal perforation: a rare but logical cause. J Laryngol Otol 110:668–669
Stegeman CA, Tervaert JW, Sluiter WJ et al (1994) Association of chronic nasal carriage of S. aureus and higher relapse rates in Wegener’s granulomatosis. Ann Intern Med 120:12–17
Watts R, Lane S, Scott DG (2005) What is known about the epidemiology of systemic vasculitis? Best Pract Res Clin Rheumatol 19:191–207
Wegener’s Granulomatosis Etanercept Trial (WGET) Research Group (2005) Etanercept plus standard therapy for Wegener’s granulomatosis. N Engl J Med 352:351–360
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Alobid, I., Mullol, J. (2010). Vasculitis Including Churg–Strauss Syndrome. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-11412-0_16
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11411-3
Online ISBN: 978-3-642-11412-0
eBook Packages: MedicineMedicine (R0)