Skip to main content

Mitomycin C Application on Caustic Esophageal Strictures

  • Chapter
  • First Online:
Esophageal and Gastric Disorders in Infancy and Childhood

Abstract

Benign esophageal stricture in children is a common complication owing commonly to gastroesophageal reflux, esophageal surgery, and ingestion of corrosive agents [1]. Management of esophageal stricture is controversial between centers, and there is no standard protocol for management worldwide; however, it is almost agreed that endoscopic dilatation is the first line of treatment trying to preserve the native esophagus [2]. However, some cases are resistant to frequent endoscopic dilatation, and, therefore, another treatment modality is indicated such as esophageal stenting or surgical intervention. Among these strictures caustic one are the most difficult to be managed with high incidence of recurrence, and most of these children referred eventually for esophageal replacement procedure [2–5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Andreollo NA, Lopes LR, Inogutti R, et al. Conservative treatment of benign esophageal strictures using dilation. Analysis of 500 cases. Rev Assoc Med Bras. 2001;47(3):236–43.

    Article  CAS  PubMed  Google Scholar 

  2. Riffat F, Cheng A. Pediatric caustic ingestion: 50 consecutive cases and a review of the literature. Dis Esophagus. 2009;22:89–94.

    Article  CAS  PubMed  Google Scholar 

  3. Kochhar R, Ray JD, Sriram PVJ, et al. Intralesional steroids augment the effects of endoscopic dilation in corrosive esophageal strictures. Gastrointest Endosc. 1999;49:509–13.

    Article  CAS  PubMed  Google Scholar 

  4. Repici A, Conio M, Angelis CD, et al. Temporary placement of an expandable polyester silicone-covered stent for treatment of refractory benign esophageal strictures. Gastrointest Endosc. 2004;60:513–9.

    Article  PubMed  Google Scholar 

  5. Poddar U, Thapa BR. Benign esophageal strictures in infants and children: results of Savary-Gilliard bougie dilation in 107 Indian children. Gastrointest Endosc. 2001;54(4):480–4.

    Article  CAS  PubMed  Google Scholar 

  6. Türkyilmaz Z, Sönmez K, Demirtola A, et al. Mitomycin C prevents strictures in caustic esophageal burns in rats. J Surg Res. 2005;123:182–7.

    Article  PubMed  Google Scholar 

  7. Anduze AL. Pterygium surgery with mitomycin-C: ten-year results. Ophthalmic Surg Lasers. 2001;32:341–5.

    CAS  PubMed  Google Scholar 

  8. Ubell ML, Ettema SL, Toohill RJ, et al. Mitomycin-c application in airway stenosis surgery: analysis of safety and costs. Otolaryngol Head Neck Surg. 2006;134(3):403–6.

    Article  PubMed  Google Scholar 

  9. Iniguez-Cuadra R, San Martin Preito J, Iniguez-Cuadra M, et al. Effect of mitomycin in the surgical treatment of tracheal stenosis. Arch Ototlaryngol Head Neck Surg. 2008;134:709–14.

    Article  Google Scholar 

  10. Perepelitsyn I, Shapshay SM. Endoscopic treatment of laryngeal and tracheal stenosis – has mitomycin C improved the outcome? Otolaryngol Head Neck Surg. 2004;131:16–20.

    Article  PubMed  Google Scholar 

  11. Rahbar R, Jones DT, Nuss RC, et al. The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe? Arch Otolaryngol Head Neck Surg. 2002;128:401–6.

    Article  PubMed  Google Scholar 

  12. Uhlen S, Fayoux P, Vachin F, et al. Mitomycin C: an alternative conservative treatment for refractory esophageal stricture in children? Endoscopy. 2006;38:404–7.

    Article  CAS  PubMed  Google Scholar 

  13. Kumar A, Bhatnagar V. Topical application of Mitomycin-c in corrosive esophageal strictures. J Indian Assoc Pediatr Surg. 2005;10(1):25–7.

    Article  Google Scholar 

  14. Olutoye OO, Shulman RJ, Cotton RT. Mitomycin C in the management of pediatric caustic esophageal strictures A case report. J Pediatr Surg. 2006;41:E1–3.

    Article  PubMed  Google Scholar 

  15. Heran MKS, Baird R, Blair GK, et al. Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. J Pediatr Surg. 2008;43:815–8.

    Article  PubMed  Google Scholar 

  16. Chung J, Connolly B, Langer J, et al. Fluoroscopy-guided topical application of mitomycin-C in a case of refractory esophageal stricture. J Vasc Interv Radiol. 2010;21:152–5.

    Article  PubMed  Google Scholar 

  17. Hamza AF, Abdelhay S, Sherif H, et al. Caustic esophageal strictures in children: 30 years’ experience. J Pediatr Surg. 2003;38(6):828–33.

    Article  PubMed  Google Scholar 

  18. Repici A, Vleggaar FP, Hassan C, et al. Efficacy and safety of biodegradable stents for refractory benign esophageal strictures: the BEST (Biodegradable Esophageal Stent) study. Gastrointest Endosc. 2010;72:927–34.

    Article  PubMed  Google Scholar 

  19. Türkyilmaz Z, Sönmez K, Karabulut R, et al. Mitomycin C decreases the rate of stricture formation in caustic esophageal burns in rats. Surgery. 2009;145:219–25.

    Article  PubMed  Google Scholar 

  20. Daher P, Riachy E, Georges B, et al. Topical application of mitomycin C in the treatment of esophageal and tracheobronchial stricture: a report of 2 cases. J Pediatr Surg. 2007;42:E9–11.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mohammed Abdel-Lalif Ayad .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

El-Asmer, K.M., Ayad, M.AL., Hamza, A.F. (2017). Mitomycin C Application on Caustic Esophageal Strictures. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11202-7_39

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11201-0

  • Online ISBN: 978-3-642-11202-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics