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Cardiovascular Aspects in Laron Syndrome Patients

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Laron Syndrome - From Man to Mouse

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The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial function, and intimal thickening. Despite small cardiac dimensions, heart function is normal, exercise capacity is significantly reduced and endothelial function is similar to that of normal controls. Brachial artery diameter was significantly smaller than controls but with no differences in endothelial function measures. Intimal thickening in the common carotid and internal carotid arteries was slightly higher in LS compared with normal controls. The data highlight the risks for cardiovascular disease in IGF-I deficiency.

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Authors and Affiliations

  1. Department of Biomedical Engineering & Neufeld, Cardiac Research Institute, Tel-Aviv University, Tel Aviv, Israel

    Mickey Scheinowitz

  2. Leviev Heart Center, Chaim Sheba Medical Center, 52621, Tel Hashomer, Ramat Gan, Israel

    Micha S. Feinberg

  3. Clinical Research Unit, Heart Institute, Chaim Sheba Medical Center, 52621, Tel Hashomer, Ramat Gan, Israel

    Michael Shechter

  4. Endocrine Research Unit, Schneider Children’s Medical Center of Israel, Kaplan Street 14, 49202, Petah Tikva, Israel

    Zvi Laron & Rivka Kauli

Authors
  1. Mickey Scheinowitz
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  2. Micha S. Feinberg
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  3. Michael Shechter
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  4. Zvi Laron
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  5. Rivka Kauli
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Corresponding author

Correspondence to Zvi Laron .

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Editors and Affiliations

  1. Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Kaplan Street 14, Petah Tikva, 49 202, Israel

    Zvi Laron

  2. Edison Biotechnology Institute, Ohio University, Athens, 45701, Ohio, USA

    J. Kopchick

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Scheinowitz, M., Feinberg, M.S., Shechter, M., Laron, Z., Kauli, R. (2011). Cardiovascular Aspects in Laron Syndrome Patients. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_33

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  • DOI: https://doi.org/10.1007/978-3-642-11183-9_33

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  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-11183-9

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