Core Message
Determination of serum liver enzyme levels revealed that with exception of the patients who had non-alcoholic fatty liver disease (NAFLD), Laron syndrome patients had variably normal levels. The Laron syndrome patients with NAFLD had slightly elevated levels. IGF-I treatment had no effect on liver enzymes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baumann U, Millar AHW, Brown RM (2008) Structure function and repair of the liver. In: Kelly D (ed) Diseases of the liver and biliary system in children, 3rd edn. Wiley-Blackwell, Chichester
Bugianesi E, Pagotto U, Manini R, Vanni E, Gastaldelli A, de Iasio R, Gentilcore E, Natale S, Cassader M, Rizzetto M, Pasquali R, Marchesini G (2005) Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab 90:3498–3504
Hampel R, Rose HJ, Jahreis G, Krabbe S, Meng W, Hesse V (1990) Bone alkaline phosphatase as an activity parameter of acromegaly. Dtsch Med Wochenschr 115:363–366
Higham CE, Chung TT, Lawrance J, Drake WM, Trainer PJ (2009) Long-term experience of pegvisomant therapy as a treatment for acromegaly. Clin Endocrinol (Oxf) 71:86–91
Laron Z, Ginsberg S, Webb M (2008) Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report. Growth Horm IGF Res 18:434–438
Preisig R, Morris TQ, Shaver JC, Christy NP (1966) Volumetric, hemodynamic, and excretory characteristics of the liver in acromegaly. J Clin Invest 45:1379–1387
Salerno M, Di Maio S, Ferri P, Lettiero T, Di Maria F, Vajro P (2000) Liver abnormalities during growth hormone treatment. J Pediatr Gastroenterol Nutr 31:149–151
Trainer PJ (2003) Lessons from 6 years of GH receptor antagonist therapy for acromegaly. J Endocrinol Invest 26(10 suppl):44–52
Acknowledgment
The contribution of T. Karmon was performed as partial fulfillment of the MD Thesis at the Sackler Faculty of Medicine, Tel Aviv University.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Berlin Heidelberg
About this chapter
Cite this chapter
Laron, Z., Karmon, T. (2011). Liver Enzymes in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_31
Download citation
DOI: https://doi.org/10.1007/978-3-642-11183-9_31
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11182-2
Online ISBN: 978-3-642-11183-9
eBook Packages: MedicineMedicine (R0)