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Determination of serum prolactin (PRL) in untreated Laron syndrome patients revealed a tendency for higher than normal values. In both untreated and IGF-I treated patients there seemed to be a certain parallelism between hGH and PRL secretion, explained by the common origin in somato-mammotrophic cells in the patients.
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References
AvRuskin TW, Pillai S, Kasi K, Juan C, Kleinberg DL (1985) Decreased prolactin secretion in childhood obesity. J Paediat 106:373–378
Cooke NE, Coit D, Weiner RI, Baxter JD, Martial JA (1980) Structure of cloned DNA complementary to rat messenger RNA. J Biol Chem 255:6502–6510
Donders SH, Pieters GF, Heevel JG, Ross HA, Smals AG, Kloppenborg PW (1985) Disparity of thyrotropin (TSH) and prolactin responses to TSH-releasing hormone in obesity. J Clin Endocr Metab 61:56–59
Frawley LS (1989) Laron syndrome (1989) Mammosomatotropes: Current status and possible functions.Trends Endocrinol Metab 1:31–54
Guyda HJ, Friesen HG (1973) Serum prolactin levels in humans from birth to adult life. Pediatr Res7:534–540
Kokkoris P, Pi-Sunyer FX (2003) Obesity and endocrine disease. Endocrinol Metab Clin N Am 32:895–914
Kopelman PG, Pilkington TRE, White N, Jeffcoate SL (1979) Impaired hypothalamic control of prolactin secretion in massive obesity. Lancet 1:747–749
Kovacs K, Horvath E, Asa SL, Stefaneanu L, Sano T (1989) Pituitary cells producing more than one hormone human pituitary adenomas. Trends Endocrinol Metab 1:104–107
Lamberts SW, Macleod RM (1990) Regulation of prolactin secretion at the level of the lactotroph. Physiol Rev 70: 279–318
Meistas MT, Foster GV, Margolis S, Kowarski AA (1982) Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity. Metabolism 31: 1224–1228
Owerbach D, Rutter WJ, Cooke NE, Martial JA, Shows TB (1981) The prolactin gene is located on chromosome 6 in humans. Science 212:815–816
Scacchi M, Pincelli AI, Cavagnini F (1999) Growth hormone in obesity. Int J Obes Relat Metab Disord 23:260–271
Silbergeld A, Klinger B, Schwartz H, Laron Z (1992) Serum prolactin in patients with Laron type dwarfism: effect on insulin like growth factor I. Horm Res 37:160–164
Sinha YN (1995) Structural variants of prolactin: occurrence and physiological significance. Endocr Rev 16:354–369
Vekemans M, Robyn C (1975) Influence of age on serum prolactin levels in women and men. Br Med J 27:738–739
Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G (1991) Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 72:51–59
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The contribution of Orly Efros was in partial fulfillment of the MD thesis requirements of the Sackler Faculty of Medicine, Tel Aviv University.
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Laron, Z., Efros, O. (2011). Serum Prolactin in Untreated and IGF-I Treated Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_28
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DOI: https://doi.org/10.1007/978-3-642-11183-9_28
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