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Untreated or late IGF-I treated patients with Laron syndrome have auditory defects. In very early treated children hearing is normal.
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Attias J, Negeris B, Zarchi O, Laron Z (2008) Hearing loss in patients with Laron syndrome (primary growth hormone insensitivity) is reversed by early IGF-I replacement therapy (Abstract #P-55). Growth Horm IGF Res 18(suppl 1):S43
Attias J, Zarchi O, Nageris BI, Laron Z (2010) Cochlear hearing loss in patients with Laron Syndrome. Eur Arch Oto-Rhino-Larnygol Head & Neck (in press)
Bonapace G, Concolino D, Formicola S, Strisciuglio P (2003) A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency. J Med Genet 40:913–917
Chernausek SD, Backeljauw PF, Frane J, Kuntze J; Underwood LE for the GH Insensitivity Syndrome Collaborative Group (2007) Long-term treatment with recombinant insulin-like growth factor (IGF)-I in children with severe IGF-1 deficiency due to growth hormone insensitivity. J Clin Endocrinol Metab 92:902–910
Iwai K, Nakagawa T, Endo T, Matsuoka Y, Kita T, Kim TS, Tabata Y, Ito J (2006) Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel. Laryngoscope 116:529–533
Laron Z (2004) Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958-2003. J Clin Endocrinol Metab 89:1031–1044
Laron Z (2009) Growth hormone and insulin-like growth factor-I: effects on the brain. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT (eds) Hormones, brain and behavior, vol 4, 2nd edn. Elsevier-Academic Press, San Diego, pp 2449–2470
Rosenbloom AL, Connor EL (2007) Hypopituitarism and other disorders of the growth hormone-insulin-like growth factor-I axis. In: Lifshitz F (ed) Pediatric endocrinology. Informa Healthcare, New York, pp 65–99
Sanchez-Calderon H, Milo M, Leon Y, Varela-Nieto I (2007) A network of growth and transcription factors controls neuronal differentiation and survival in the developing ear. Int J Dev Biol 51:557–570
Shevah O, Laron Z (2006) Genetic analysis of the pedigrees and molecular defects of the GH-receptor gene in the Israeli cohort of patients with Laron syndrome. Pediatr Endocrinol Rev 3:489–497
Walenkamp MJE, Karperien M, Pereira AM, Hilhorst-Hofstee Y, van Doorn J, Chen JW, Mohan S, Denley A, Forbes B, van Duyvenvoorde HA, van Thiel SW, Sluimers CA, Bax JJ, de Laat JA, Breuning MB, Romijn JA, Wit JM (2005) Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab 90:2855–2864
Woods KA, Camacho-Hubner SMO, Clark AJ (1996) Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 335:1363–1367
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© 2011 Springer Berlin Heidelberg
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Laron, Z., Zarchi, O., Attias, J. (2011). Hearing in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_22
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DOI: https://doi.org/10.1007/978-3-642-11183-9_22
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