Skip to main content
SpringerLink
Log in

Early Investigations: Characterizations of the Circulating Growth Hormone

  • Chapter
  • First Online:
Laron Syndrome - From Man to Mouse

  • 586 Accesses

Core Messages

The introduction of radioimmunoassays in the 1960ies led to the recognition that the patients who clinically resembled GH deficiency but had high serum hGH levels, had a new disease entity.

This chapter describes the psychological pattern of circadian hGH secretion in Laron syndrome patients, and the response to stimulatory and suppressing agents. Immunological tests and radioreceptor assays showed that the hGH molecule is normal. Liver biopsies from 2 LS patients proved that the hGH receptor is defect.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL (1981) Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212:1279–1281

    Article  PubMed  CAS  Google Scholar 

  • Daughaday WH, Laron Z, Pertzelan A, Heins JN (1969) Defective sulfation factor generation: a possible etiological link in dwarfism. Trans Assoc Am Phys 82:129–138

    PubMed  CAS  Google Scholar 

  • Eshet R, Laron Z, Brown M, Arnon R (1973) Immunoreactive properties of the plasma hGH from patients with the syndrome of familial dwarfism and high plasma IR-hGH. J Clin Endocrinol Metab 37:819–821

    Article  PubMed  CAS  Google Scholar 

  • Eshet R, Laron Z, Brown M, Arnon R (1974) Immunological behaviour of hGH from plasma of patients with familial dwarfism and high IR-hGH in a radioimmunoassay system using the cross-reaction between hGH and HCS. Horm Metab Res 6:80–81

    Article  PubMed  CAS  Google Scholar 

  • Eshet R, Laron Z, Pertzelan A, Dintzman M (1984) Defect of human growth hormone in the liver of two patients with Laron type dwarfism. Isr J Med Sci 20:8–11

    PubMed  CAS  Google Scholar 

  • Eshet R, Peleg S, Josefsberg Z, Fuchs C, Arnon R, Laron Z (1985) Some properties of the plasma hGH activity in patients with Laron-type dwarfism determined by a radioreceptor assay using human liver tissue. Horm Res 22:276–283

    Article  PubMed  CAS  Google Scholar 

  • Golde DW, Bersch N, Kaplan SA, Rimolin DL, Li CH (1980) Peripheral unresponsiveness to human growth hormone in Laron dwarfism. N Engl J Med 303:1156–1159

    Article  PubMed  CAS  Google Scholar 

  • Hartman ML (2000) Physiological regulators of growth hormone secretion. In: Juul A, Jorgensen JOL (eds) Growth hormone in adults, 2nd edn. Cambridge University Press, Cambridge, pp 3–53

    Chapter  Google Scholar 

  • Herington AC, Jacobs LS, Daughaday WH (1974) Radioreceptor and radioimmunoassay quantitation of human growth ­hormone in acromegalic serum: overestimation by immunoassay and systematic differences between antisera. Clin Endocrinol Metab 39:257–262

    Article  CAS  Google Scholar 

  • Jacobs LS, Sneid DS, Garland JT, Laron Z, Daughaday WH (1976) Receptor-active growth hormone in Laron dwarfism. J Clin Endocrinol Metab 43:403–406

    Article  Google Scholar 

  • Keret R, Pertzelan A, Zeharia A, Zadik A, Laron Z (1988) Growth hormone (hGH) secretion and turnover in three patients with Laron-type dwarfism. Isr J Med Sci 34:75–79

    Google Scholar 

  • Kleine TO, Merten B, Meier HW, Nevo Z, Kowadlo-Silbergeld A, Mamet R, Laron Z (1980) Effect of normal and pathological sera of patients with low serum somatomedin levels on proteoglycan glycosaminglycan biosynthesis in two types of cartilage. In: Robert AM, Robert L (eds) Biochimie des Tissue Conjonctifs Normaux et Pathologiques. CBRS, Paris, pp 173–175

    Google Scholar 

  • Laron Z (1984) Laron type dwarfism (hereditary somatomedin deficiency): a review. In: Frick P, Von Harnack GA, Kochsiek K, Martini GA, Prader A (eds) Advances in internal medicine and pediatrics. Springer, Berlin, pp 117–150

    Google Scholar 

  • Laron Z, Mannheimer S (1966) Measurement of human growth hormone. Description of the method and its clinical applications. Isr J Med Sci 2:115–119

    PubMed  CAS  Google Scholar 

  • Laron Z, Pertzelan A, Mannheimer S (1966) Genetic pituitary dwarfism with high serum concentration of growth hormone. A new inborn error of metabolism? Isr J Med Sci 2:152–155

    PubMed  CAS  Google Scholar 

  • Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4:883–894

    PubMed  CAS  Google Scholar 

  • Laron Z, Pertzelan A, Karp M, Kowadlo-Silbergeld A, Daughaday WH (1971) Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone. Measurement of sulfation factor, metabolic, and linear growth responses. J Clin Endocrinol Metab 33:332–342

    Article  PubMed  CAS  Google Scholar 

  • Laron Z, Pertzelan A, Doron M, Assa S, Keret R (1977) The effect of dihydrosomatostatin in dwarfism with high plasma immunoreactive growth hormone. Horm Metab Res 9:338–339

    Article  PubMed  CAS  Google Scholar 

  • Laron Z, Kowaldo-Silbergeld A, Eshet R, Pertzelan A (1980) Growth hormone resistance. Ann Clin Res 12:269–277

    PubMed  CAS  Google Scholar 

  • MacGillivray MH, Frohman LA, Doe J (1970) Metabolic clearance and production rates of human growth hormone in subjects with normal and abnormal growth. J Clin Endocrinol Metab 30:632–638

    Article  PubMed  CAS  Google Scholar 

  • Nevo Z, Mimouni M, Laron Z (1977) Growth parameters of cultured skin fibroblasts and growth promoting activity of sera from patients with growth disturbances (Abstract). Isr J Med Sci 33:1242

    Google Scholar 

  • Owens D, Srivastava MC, Tompkins CV, Nabarro JD, Sönksen PH (1973) Studies on the metabolic clearance rate, apparent distribution space and plasma half-disappearance time of unlabelled human growth hormone in normal subjects and in patients with liver disease, renal disease, thyroid disease and diabetes mellitus. Eur J Clin Invest 3:284–294

    Article  PubMed  CAS  Google Scholar 

  • Sneid DS, Jacobs LS, Weldon VV, Trivedi BL, Daughaday H (1975) Radioreceptor-inactive growth hormone associated with stimulated secretion in normal subjects. J Clin Endocrinol Metab 41:471–474

    Google Scholar 

  • Tsushima T, Friesen HG (1973) Radioreceptor assay for growth hormone. J Clin Endocrinol Metab 37:334–337

    Article  PubMed  CAS  Google Scholar 

  • Zadik Z, Chalew SA, McCarter RJ Jr, Meistas M, Kowarski AA (1985) The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 60:513–516

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endocrine Research Unit, Schneider Children’s Medical Center of Israel, Kaplan Street 14, 49202, Petah Tikva, Israel

    Zvi Laron

Authors
  1. Zvi Laron
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zvi Laron .

Editor information

Editors and Affiliations

  1. Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Kaplan Street 14, Petah Tikva, 49 202, Israel

    Zvi Laron

  2. Edison Biotechnology Institute, Ohio University, Athens, 45701, Ohio, USA

    J. Kopchick

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Laron, Z. (2011). Early Investigations: Characterizations of the Circulating Growth Hormone. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11183-9_2

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11182-2

  • Online ISBN: 978-3-642-11183-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation