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Serum Lipids in Patients with Laron Syndrome

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Laron Syndrome - From Man to Mouse
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This chapter describes the serum concentrations of blood lipids (FFA, cholesterol and lipoprotein [a]) along age in patients with Laron syndrome. The main observation is the progressive increase of serum cholesterol necessitating pharmacotherapy.

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References

  • Berg K (1963) A new serum type system in man–The LP system. Acta Pathol Microbiol Scand 59:369–382

    Article  PubMed  CAS  Google Scholar 

  • Cohen H, Shamir R (2007) Lipid disorders in children and adolescents. In: Lifshitz F (ed) Pediatric endocrinology, vol 1, 5th edn. INFORMA Healthcare, New York, pp 279–290

    Google Scholar 

  • Dole VP, Meinertz H (1960) Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem 235: 595–2599

    PubMed  CAS  Google Scholar 

  • Durrington PN (2007) Hyperlipidaemia – diagnosis and management, 3rd edn. Hodder Arnold, London, pp 1–398

    Book  Google Scholar 

  • Edén S, Wiklund O, Oscarsson J, Rosén T, Bengtsson BA (1993) Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations. Arterioscler Thromb 13:296–301

    Article  PubMed  Google Scholar 

  • Kissebah AH, Krakower GR (1999) Endocrine disorders. In: Betteridge DJ, Illingworth DR, Shepherd J (eds) Lipoproteins in health and disease. Arnold, London, pp 931–941

    Google Scholar 

  • Lackner C, Cohen JC, Hobbs HH (1993) Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum Mol Genet 2:933–940

    Article  PubMed  CAS  Google Scholar 

  • Laron Z (1984) Laron type dwarfism (hereditary somatomedin deficiency): a review. In: Frick P, Von Harnack GA, Kochsiek K, Martini GA, Prader A (eds) Advances in Internal Medicine and Pediatrics. Springer, Berlin-Heidelberg, pp 117–150

    Google Scholar 

  • Laron Z, Karmon T (2010) Long-term changes in blood lipids and liver function in patients with Laron syndrome M.D. Thesis, Sackler Faculty of Medicine, Tel Aviv University, Israel

    Google Scholar 

  • Laron Z, Klinger B (1993) Body fat in Laron syndrome patients: effect of insulin-like growth factor treatment. Horm Res 40: 16–22

    Article  PubMed  CAS  Google Scholar 

  • Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4: 883–894

    PubMed  CAS  Google Scholar 

  • Laron Z, Wang XL, Klinger B, Silbergeld A, Wilcken DEL (1996) Insulin-like growth factor I lowers serum lipoprotein(a) during long-term treatment of patients with Laron syndrome. Metabolism 45:1–5

    Article  Google Scholar 

  • Laron Z, Wang XL, Klinger B, Silbergeld A, Wilcken DEL (1997) Growth hormone increases and insulin-like growth factor-I decreases circulating lipoprotein(a). Eur J Endocrinol 136:377–381

    Article  PubMed  CAS  Google Scholar 

  • McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM (1987) cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330:132–137

    Article  PubMed  CAS  Google Scholar 

  • Merimee TJ, Hollander W, Fineberg SE (1972) Studies of hyperlipidemia in the hGH-deficient state. Metabolism 21:1053–1061

    Article  PubMed  CAS  Google Scholar 

  • Nikkilä EA, Pelkonen R (1975) Serum lipids in acromegaly. Metabolism 24:829–838

    Article  PubMed  Google Scholar 

  • Rappaport F, Eichhorn F (1950) A rapid titrimetric micromethod for determination of blood sugar. Am J Clin Pathol 20:834–836

    PubMed  CAS  Google Scholar 

  • Suk Danik J, Rifai N, Buring JE, Ridker PM (2006) Lipoprotein(a), measured with an assay independent of apolipoprotein(a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA 296:1363–1370

    Article  PubMed  CAS  Google Scholar 

  • Summers VK, Hipkin LJ, Davis JC (1967) Serum lipids in diseases of the pituitary. Metabolism 12:1106–1113

    Article  Google Scholar 

  • Wang XL, Wilcken DEL, Dudman NPB (1992) An indirect sandwich ELISA for LP(a) in serum and dried blood spots. Clin Chim Acta 207:73–86

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

T. Karmon contributed to collect the data along age in partial fulfillment of the MD thesis requirements of the Sackler Faculty of Medicine, Tel Aviv University

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Correspondence to Zvi Laron .

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© 2011 Springer Berlin Heidelberg

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Laron, Z. (2011). Serum Lipids in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-11183-9_15

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11182-2

  • Online ISBN: 978-3-642-11183-9

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