Abstract
The vertebrate Central Nervous System (CNS) originates from the embryonic dorsal ectoderm. Differentiation of the neural plate epithelium from the ectoderm constitutes the first phase of complex processes called gastrulation and neurulation, which culminates in the formation of the neural tube. During these processes, molecular and cellular mechanisms are orchestrated to specify the body and CNS axes. This is a required step to generate topological landmarks, from were positional information will be distributed by morphogenetic signals controlling cell differentiation and organogenesis.
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Martínez, S., Puelles, E., Echevarria, D. (2013). Ontogeny of the Vertebrate Nervous System. In: Galizia, C., Lledo, PM. (eds) Neurosciences - From Molecule to Behavior: a university textbook. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10769-6_3
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