Abstract
The pandemic (H1N1) 2009 virus is life-threatening for some patients. Analysis of virus genome sequences has provided biomedical scientists new insight in understanding host-virus interaction. We have addressed the questions if HA protein is in related to virulence of viruses. To test the hypothesis, we have focuses our analysis on the protein of hemagglutinant (HA), a protein , from the virus isolated three regions with similar living standard, popuin HongKong (death rate: 2.57 per million), Taiwan (death rate: 0.74 per million) and Japan (death rate: 0.14 per million). Our results suggest that in the human population, the virus H1N1 have isolated several time both in Taiwan and Japan, as early as in 2002 and with a dominant occurrence in 2009. However, through phylogenetic analysis, the The recent outbreak of H1N1 has different sequence origin than the previous ones. And, between the years of 2002-2008, the dominant virus stain is H3N2. The results suggest that the general population in Taiwan might not have the immunity against the new virus.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cox, N.J., Subbarao, K.: Global epidemiology of influenza: past and present. Annu. Rev. Med. 51, 407–421 (2000)
United States Department of Commerce. Historical statistics of the United States: Colonial times to 1970. Government Printing Office, Washington, DC (1976)
Crosby, A.: America’s forgotten pandemic. Cambridge University Press, Cambridge (1989)
Johnson, N.P., Mueller, J.: Updating the accounts: global mortality of the 1918–1920 “Spanish” influenza pandemic. Bull. Hist. Med. 76, 105–115 (2002)
Patterson, K.D., Pyle, G.: The geography and mortality of the 1918 influenza pandemic. Bull. Hist. Med. 65, 4–21 (1991)
Simonsen, L., Clarke, M.J., Schonberger, L.B., Arden, N.H., Cox, N.J., Fukuda, K.: Pandemic versus epidemic influenza mortality: A pattern of changing age distribution. J. Infect. Dis. 178, 53–60 (1998)
Webby, R.J., Webster, R.: Are we ready for pandemic influenza? Science 302, 1519–1522 (2003)
Webster, R.G., Bean, W.J., Gorman, O.T., Chambers, T.M., Kawaoka, Y.: Evolution and ecology of influenza A viruses. Microbiol. Rev. 56, 152–179 (1992)
Ludwig, S., Stitz, L., Planz, O., Van, H., Fitch, W., Scholtissek, C.: European swine virus as a possible source for the next influenza pandemic? Virology 212, 551–561 (1995)
Scholtissek, C.: Source for influenza pandemics. Eur. J. Epidemiol. 10, 455–458 (1994)
Kawaoka, Y., Krauss, S., Webster, R.: Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J. Virol. 63, 4603–4608 (1989)
Scholtissek, C., Koennecke, I., Rott, R.: Host range recombinants of fowl plague (influenza A) virus. Virology 91, 79–85 (1978)
Claas, E.C., Osterhaus, A.D., van Beek, R., De Jong, J.C., Rimmelzwaan, G.F., Senne, D.A., Krauss, S., Shortridge, K.F., Webster, R.G.: Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351, 472–477 (1998)
Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C., Huang, J., Hemphill, M., Rowe, T., Shaw, M., Xu, X., Fukuda, K., Cox, N.: Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393–396 (1998)
Katz, J., Lim, W., Bridges, C., Rowe, T., Hu-Primmer, J., Lu, X., Abernathy, R., Clarke, M., Conn, L., Kwong, H., Lee, M., Au, G., Ho, Y., Mak, K., Cox, N., Fukuda, K.: Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts. J. Infect. Dis. 180, 1763–1770 (1999)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hwa, Ky. (2009). Phylogenetic Analysis of HA Proteins of Influenza Virus H1N1 Reveal New Insight on Virus Pandemic. In: Ślęzak, D., Arslan, T., Fang, WC., Song, X., Kim, Th. (eds) Bio-Science and Bio-Technology. BSBT 2009. Communications in Computer and Information Science, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10616-3_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-10616-3_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-10615-6
Online ISBN: 978-3-642-10616-3
eBook Packages: Computer ScienceComputer Science (R0)