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Biohybrid and Peptide-Based Polymer Vesicles

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Polymer Membranes/Biomembranes

Part of the book series: Advances in Polymer Science ((POLYMER,volume 224))

Abstract

This review covers the major processes and mechanisms involved in the production of biohybrid or peptide-based polymer vesicles by self-assembly. The formation of vesicles conventionally occurs based on geometric packing issues, and becomes predominant when the membrane-forming segment is stiffened due to hydrogen bonding and secondary structure interactions or supramolecular complexation. The vesicles are used for applications in life science, for the purpose of drug/gene delivery, cell surface recognition, and as bioreactors, and for the production of composite materials.

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Abbreviations

Ala, A:

Alanine

Arg, R:

Arginine

Asp, D:

Aspartic acid

AspA:

Aspartamide

Bzl, B:

Benzyl

CD:

Circular dichroism

Cys, C:

Cysteine

DFM:

Dark-field microscopy

DIC:

Differential interference contrast

DLS:

Dynamic light scattering

DMF:

N,N-Dimethylformamide

DNA:

Desoxyribonucleic acid

EYPG:

Egg yolk phosphatidyl glycerol

FM:

Fluorescence microscopy

FTIC:

Fluoresceine isothiocyanate

Glc:

Glucose

Gln, Q:

Glutamine

Glu, E:

Glutamic acid

IR:

Infrared

Lac:

Lactose

LCST:

Lower critical solution temperature

Leu, L:

Leucine

LSCM:

Laser scanning confocal microscopy

Lys, K:

Lysine

Mb:

Myoglobin

Me, M:

Methyl

MRI:

Magnetic resonance imaging

NMR:

Nuclear magnetic resonance

OM:

Optical microscopy

PB:

Polybutadiene

PDEGMA:

Poly(diethyleneglycol methacrylate)

PEG, PEO:

Poly(ethylene glycol), poly(ethylene oxide)

PELLys:

Poly(N ε-[2-(2-(methoxyethoxy)ethoxy)]acetyl-l-lysine)

PGEA:

Poly(2-(β-d-glucopyranosyloxy)ethyl acrylate)

PGEMA:

Poly(2-glucosyloxyethyl methacrylate)

Phe, F:

Phenylalanine

PHPMA:

Poly(N-(2-hydroxypropyl)methacrylamide)

PIAA:

Polyisocyanodipeptide

PIC:

Polyion complex

PMMA:

Poly(methyl methacrylate)

PNIPAM:

Poly(N-isopropylacrylamide)

PS:

Polystyrene

R g :

Radius of gyration

R h :

Hydrodynamic radius

SANS:

Small-angle neutron scattering

SAXS:

Small-angle X-ray scattering

SEM:

Scanning electron microscopy

SFM:

Scanning force microscopy

SLS:

Static light scattering

TEM:

Transmission electron microscopy

THF:

Tetrahydrofuran

Z:

Benzyloxycarbonyl

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Acknowledgement

H.S. thanks all former and present coworkers working in the field of biohybrid polymers and Erich C. (beerandfunandloudmusic). Financial support was given by the Max Planck Society and the German Research Foundation (within the Eurocores Programme BIOSONS).

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Authors and Affiliations

  1. Max Planck Institute of Colloids and Interfaces, Colloid Department, Research Campus Golm, Potsdam, 14424, Germany

    Annabelle Bertin, Florian Hermes & Helmut Schlaad

Authors
  1. Annabelle Bertin
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  2. Florian Hermes
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  3. Helmut Schlaad
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Corresponding author

Correspondence to Helmut Schlaad .

Editor information

Editors and Affiliations

  1. Dept. Chemie, Universität Basel, Klingelbergstr. 80, Basel, 4056, Switzerland

    Wolfgang Peter Meier

  2. MPI für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany

    Wolfgang Knoll

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Bertin, A., Hermes, F., Schlaad, H. (2009). Biohybrid and Peptide-Based Polymer Vesicles. In: Meier, W., Knoll, W. (eds) Polymer Membranes/Biomembranes. Advances in Polymer Science, vol 224. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10479-4_12

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