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Introduction

  • Fiona Cunningham
  • Jonathan Elliott
  • Peter LeesEmail author
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 199)

Abstract

The origins of veterinary pharmacology and therapeutics are the same as those of the equivalent human disciplines, lying in the administration of and responses to plants and extracts of plants containing pharmacologically active compounds. The history of Materia Medica, and then the emergence of pharmacology and therapeutics in humans have been extensively described. Appelgren (2009) has provided a recent summary of both the human and parallel veterinary developments. He describes the early records contained: (a) in Egyptian papyri (1800–1200 bc), the contents of which became known only from 1822 when the Rosetta stone was translated and; (b) in the writings of the Greeks (notably Hippocrates, 430 bc) and later Galen (94 ad). Hippocrates' and Galen's prescriptions dominated European medicine for many centuries, through the medieval periods, until superseded in the Age of Enlightenment. As Appelgren points out, we can certainly conclude that the same “drugs” were used in animals and man up to and beyond the Age of Enlightenment. There was, however, at this time an expression of concern relating to the use of drugs therapeutically in animals on the basis of human experience. As voiced by the Swedish botanist and doctor Carolus Linneaus, “human medicines are used for animals without knowledge if they work, which is devastating barbarism”. At that time much of the progress in veterinary medicine was made in France, and Linneaus sent Peter Hernquist to France to learn the scientific principles underlying veterinary medicine. In 1791, Charles Vial de St. Bel left the Lyon school to found the first veterinary teaching establishment in the English speaking world, the Royal Veterinary College in London, later to become a constituent College of the University of London.

Keywords

Antimicrobial Drug Human Pharmacology Royal Veterinary College Rosetta Stone Salicyl Alcohol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Appelgren L-E (2009) Veterinary drugs: yesterday, today and tomorrow. J Vet Pharmacol Ther 32(Suppl 1):7–10Google Scholar
  2. Cox SP, Liao SHT, Payne-Johnson M, Zielinski RJ, Hawkesford R, Maitland TP, Tilt N, Lawrence B, Bullard J, Stegemann MR (2009) Population pharmacokinetics (PPK) of mavacoxib in osteoarthritic (OA) dogs. J Vet Pharmacol Ther 32(Suppl 1):107–108Google Scholar
  3. Dun F (1895) Veterinary medicines: their actions and uses, 9th edn. Edinburgh University Press, Edinburgh, p 602Google Scholar
  4. Giraudel JM, Peyrou M, King JN, Gruet P (2009) Population pharmacokinetic analysis of blood robenacoxib data from two dose confirmation field studies in dogs with osteoarthritis. J Vet Pharmacol Ther 32(Suppl 1):102–103Google Scholar
  5. Lees P (2009) Analgesic, anti-inflammatory, antipyretic drugs. In: Riviere JE, Papich MG (eds) Veterinary pharmacology and therapeutics, 9th edn. Wiley-Blackwell, Iowa, pp 457–492Google Scholar
  6. Lees P, Landoni MF, Giraudel J, Toutain P-L (2004) Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest. J Vet Pharmacol Ther 27:479–490CrossRefPubMedGoogle Scholar
  7. Mealey KL, Bentjen SA, Waiting DK (2002) Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States. Am J Vet Res 63:479–481CrossRefPubMedGoogle Scholar
  8. Paulson SK, Eagel L, Reitz B, Bolten S, Burton EG, Mazias TJ, Yan B, Schoenhard GL (1999) Evidence of polymorphism in the canine metabolism of the cyclooxygenase-2 inhibitor, celecoxib. Drug Metab Disp 27:1133–1142Google Scholar
  9. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biology) 231:232–235Google Scholar
  10. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96:7563–7568CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Fiona Cunningham
    • 1
  • Jonathan Elliott
    • 2
  • Peter Lees
    • 1
    Email author
  1. 1.Department of Veterinary Basic SciencesRoyal Veterinary CollegeNorth MymmsUK
  2. 2.Department of Veterinary Basic SciencesRoyal Veterinary CollegeLondonUK

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