Abstract
Human genomic data is a treasure that holds rich information for bioresearch. The share of human genomic data is necessary for the continuous progress of biology, medicine and health research. However, human genomic data also contains private information of individuals. Human genomic data may be maliciously used to find out the genetic tendency for a disease, and even to track descendents and relatives of the individual. In this paper, we review some techniques for protecting privacy in sharing human genomic data and discuss problems and challenges.
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References
Altman, R., Klein, T.: Challenges for biomedical informatics and pharmacogenomics. Annual Review of Pharmacology and Toxicology 42, 113–133 (2002)
McGurie, A.L., Gibbs, R.A.: No longer de-identified. Science 312, 370 (2006)
Burnett, L., Barlow-Stewart, K., Pros, A.L., Aizenberg, H.: The gene trustee: a universal identification system that ensures privacy and confidentiality for human genetic databases. Journal of Law and Medicine 4(10), 506–513 (2003)
Churches, T.: A proposed architecture and method of operation for improving the protection of privacy and confidentiality in disease registers. BMC Medical Research Methodology 1, 3–15 (2003)
Claude, D., Benigni, X., Barillot, E., Vaysseix, G.: Dbcat: A catalog of 500 biological databases. Nucleic Acids Research 1(28), 8–9 (2009)
Evans, W., Relling, M.: Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 286, 487–491 (1999)
Gaudet, D., Arsnault, S., Belanger, C.: Procedure to protect confidentiality of familial data in community genetics and genomics research. Clinical Genetics 55(4), 259–264 (1999)
GINA, Genetic Information Non-discrimination Act. US (2008), http://www.genome.gov/24519851
Gulcher, J., Kristjansson, K., Gudbjartsson, H., Stefanson, K.: Protection of privacy by third-party encryption in genetic research. European Journal of Human Genetics 8, 739–742 (2000)
Gulcher, J., Kong, A., Stefanson, K.: The genealogic approach to human genetics. Cancer 7(1), 61–68 (2001)
HGDP, Human Genome Diversity Project (2002), http://www.stanford.edu/group/morrinst/hgdp.html
Liebecq, C.: Biochemical Nomenclature and Related Documents: A Compendium, 2nd edn. Chapel Hill, NC, Portland Press (2009)
Lin, Z., Hewitt, M., Altman, R.B.: Using binning to maintain confidentiality of medical data. In: American Medical Informatics Association Annual Symposium, pp. 454–458 (2002)
Lin, Z., Owen, A.B., Altman, R.B.: Genomic research and human subject privacy. Science 305, 183 (2004)
Malin, B.A.: An evaluation of the current state of genomic data privacy protection technology and a roadmap for the future. Journal of the American Medical Informatics Association 12, 28–34 (2005)
Malin, B.A.: Protecting genomic sequence anonymity with generalization lattices. Methods of Information in Medicine 44(5), 687–692 (2005)
Malin, B.A., Sweeny, L.: Determining the identifiability of dna database entries. Journal of the American Medical Informatics Association, 537–541 (2000)
Malin, B.A., Sweeny, L.: Re-identification of DNA through an automated linkage process. Journal of the American Medical Informatics Association, 423–427 (2001)
Malin, B.A., Sweeny, L.: Inferring genotype from clinical phenotype through a knowledge based algorithm. In: Pacific Symposium of Biocomputing, pp. 41–52 (2002)
Malin, B.A., Sweeny, L.: How (not) to protect genomic data privacy in a distributed network: using trail re-identification to evaluate and design anonymity protection systems. Journal of the American Medical Informatics Association 37, 179–192 (2004)
de Moor, G.J., Claerhout, B., de Meyer, F.: Privacy enhancing technologies: the key to secure communication and management of clinical and genomic data. Methods of Information in Medicine 42, 148–153 (2003)
West, M., Ginsburg, G., Huang, A., Nevins, J.: Embracing the complexity of genomic data for personalized medicine. Genome Research 16, 559–566 (2006)
NHGRI, Guidance on Human Subjects Issues in Large-Scale DNA Sequencing. National Human Genome Research Institute (1996), http://www.genome.gov/10000921
Roses, A.: Pharmacogenetics and pharmacogenomics in the discovery and development of medicines. Nature 38, 815–818 (2000)
Sweeney, L.: Weaving technology and policy together to maintain confidentiality. Journal of Law and Medicine 25, 98–111 (1997)
Sweeney, L.: Uniqueness of simple demographics in the U.S. population. Tech. Rep. LIDAP-WP4, Data Privacy Laboratory, Carnegie Mellon University, Pittsburgh, PA (2000)
Sweeney, L.: K-anonymity: A model for protecting privacy. Uncertainty, Fuzziness and Knowledge-based Systems 10, 557–570 (2002)
Vaszar, L.T., Cho, M.K., Raffin, T.A.: Privacy issues in personalized medicine. Pharmacogenomics 4, 107–112 (2003)
Wylie, J.E., Mineau, G.P.: Biomedical databases: protecting privacy and promoting research. Trends Biotechnol. 21, 113–116 (2003)
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Baig, M.M., Li, J., Liu, J., Wang, H., Wang, J. (2010). Privacy Protection for Genomic Data: Current Techniques and Challenges. In: Ras, Z.W., Tsay, LS. (eds) Advances in Intelligent Information Systems. Studies in Computational Intelligence, vol 265. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05183-8_7
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DOI: https://doi.org/10.1007/978-3-642-05183-8_7
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