Zusammenfassung
Das Pankreaskarzinom ist ein aggressiver Tumor, der zu einer frühzeitigen lymphogenen Dissemination neigt. Zum Operationszeitpunkt weisen über 50% der Patienten bereits makroskopische Lymphknotenmetastasen auf (Nagakawa et al. 1996). Neben klinisch pathologischen Merkmalen wie Tumorlokalisation, Durchmesser, DNAGehalt, Infiltration von Gefäßen und Perineuralscheiden, ist das Vorliegen von Lymphknotenmetastasen ein etablierter prognostischer Indikator (Geer et al. 1993).
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Literatur
Berger AC, Watson JC, Ross EA, et al. (2004) The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am Surg 70:235-40.
Cubilla AL, Fortner J, Fitzgeral PJ (1978) Lymph node involvement in carcinoma of the head of the pancreas area. Cancer 41:880-7.
Farnell MB, Pearson RK, Sarr MG, et al. (2005) A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 138:618-28.
Fortner JG (1973) Regional resection of cancer of the pancreas: a new surgical approach. Surgery 73:307-20.
Geer RJ, Brennan MF(1993) Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 165:68-72.
Hosch SB, Knoefel WT, Metz S, et al. (1997) Early lymphatic tumor cell dissemination in pancreatic cancer: frequency and prognostic significance. Pancreas. 15:154-9.
Imaizumi T, Hanyu F, Harada N, et al. (1998) Extended radical Whipple resection for cancer of the pancreatic head: operative procedure and results. Dig Surg 15:299-307.
Isaji S, Kawarada Y, Uemoto S (2004) Classification of pancreatic cancer: comparison of Japanese and UICC classifications. Pancreas 28:231-4.
Ishikawa O, Ohhigashi H, Sasaki Y, et al. (1988) Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Ann Surg 208:215-20.
Ishikawa O, Wada H, Ohigashi H, et al. (2003) Postoperative cytology for drained fluid from the pancreatic bed after «curative» resection of pancreatic cancers: does it predict both the patient’s prognosis and the site of cancer recurrence? Ann Surg. 238:103-10.
JPS, Japan Pancreas Society (2003) Classification of Pancreatic Carcinoma (2nd edn.) Kanehara: Tokyo
Kayahara M, Nagakawa T, Kobayashi H, et al. (1992) Lymphatic flow in carcinoma of the head of the pancreas. Cancer. 70:2061-6.
Kayahara M, Nagakawa T, Ohta T, et al. (1999) Analysis of paraaortic lymph node involvement in pancreatic carcinoma: a significant indication for surgery? Cancer. 85:583-90.
Kremer B, Vogel I, Luttges J, et al. (1999) Surgical possibilities for pancreatic cancer: extended resection. Ann Oncol. 10 Suppl 4:252-6.
Manabe T, Ohshio G, Baba N, et al. (1989) Cancer Radical pancreatectomy for ductal cell carcinoma of the head of the pancreas. Cancer. 64:1132-7.
Nagakawa T, Konishi I, Ueno K, et al. (1993) A clinical study on lymphatic flow in carcinoma of the pancreatic head area—peripancreatic regional lymph node grouping. Hepatogastroenterology 40:457-62.
Nagakawa T, Nagamori M, Futakami F, et al. (1996) Results of extensive surgery for pancreatic carcinoma. Cancer. 77:640-5.
Nakao A, Harada A, Nonami T (1997) Lymph node metastasis in carcinoma of the body and tail of the pancreas. Br J Surg. 84:1090-2.
Nakao A, Takeda S, Sakai M, et al (2004) Extended radical resection versus standard resection for pancreatic cancer: The rationale for extended radical resection. Pancreas 28:289-92.
Peiper M, Boelke E, Orth K, Hosch SB, Rehders A, Matthaei H, Knoefel WT (2007) Current status of radical systematic lymphadenectomy in pancreatic cancer – a review of the literature. Eur J Med Res. 12:47-53.
Pedrazzoli S, Beger HG, Obertop H, et al. (1999) A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer. Dig Surg. 16:337-45.
Pedrazzoli S, DiCarlo V, Dionigi R, et al. (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg. 228:508-17.
Riall TS, Cameron JL, Lillemoe KD, et al. (2005) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma– part 3: update on 5-year survival. J Gastrointest Surg. 9:1191-204.
Richter A, Niedergethmann M, Sturm JW, et al. (2003) Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience.World J Surg. 27:324-9.
Sakai M, Nakao A, Kaneko T, et al. (2005) Para-aortic lymph node metastasis in carcinoma of the head of the pancreas. Surgery 137:606-11.
Schniewind B, Bestmann B, Henne-Bruns D, et al. (2006) Quality of life after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head. Br J Surg 93:1099-107.
Schwarz RE, Smith DD. (2006) Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database. Ann Surg Oncol 13:1189-200.
Shimada K, Sakamoto Y, Sato T, et al. (2006) The role of paraaortic lymph node involvement on early recurrence and survival after macroscopic curative resection with extended lymphadenectomy for pancreatic carcinoma.J Am Coll Surg. 203:345-52.
Sierzega M, Popiela T, Kulig J, et al. (2006) The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer. Pancreas 33:240-5.
Sperti C, Pasquali C, Piccoli A, et al. (1997) Recurrence after resection for ductal adenocarcinoma of the pancreas.World J Surg. 21:195-200.
Thorban S, Roder JD, Siewert JR. (1999) Detection of micrometastasis in bone marrow of pancreatic cancer patients. Ann Oncol. 10 Suppl 4:111-3.
Todoroki T, Koike N, Morishita Y, et al. (2003) Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater. Ann Surg Oncol. 10:1176-83.
Traverso LW. (2006) Pancreatic cancer: surgery alone is not sufficient. Surg Endosc. 20 Suppl 2:S446-9.
Wagner M, Radaelli C, Lietz M, et al. (2004) Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg. 91:586-94.
Yeo CJ, Cameron JL, Lillemoe KD, et al. (2002) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 236:355-68.
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Rehders, A., Peiper, M., Knoefel, W. (2010). Lymphadenektomie in der Pankreaschirurgie. In: Hepatobiliäre und Pankreastumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04935-4_24
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DOI: https://doi.org/10.1007/978-3-642-04935-4_24
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