Abstract
Optical methods are the preferred measurement techniques for biosensors and lab-on-chip applications. Their key properties are sensitivity, selectivity and robustness. To simplify the systems and their operation, it is desirable to employ label-free optical methods, requiring the functionalization of interfaces. Evanescent electromagnetic waves are probing the optical proper ties near the interfaces, a few 100 nm deep into the sample fluid. The sensitivity of these measurements can be improved with optical micro-resonators, in particular whispering gallery mode devices. Q factors as high as 2x108 have been achieved in practice. The resulting narrow-linewidth resonances and an unexpected thermo-optic effect make it possible to detect single biomolecules using a label-free biosensor principle. Future generations of biosensors and labs-on-chip for point-of-care and high-troughput screening applications will require large numbers of parallel measurement channels, necessitating optical micro-resonators in array format produced very cost-effectively.
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References
van Beek, J.H.G.M.: Channeling the Data Flow: Handling Large-Scale Biological Measurements in Silico. Proceedings of the IEEE 94, 692–709 (2006)
Seitz, P.: Optical Biochips. In: Biophotonics, pp. 217–226. Springer, Berlin (2008)
Armani, A.M., Kulkarni, R.P., Fraser, S.E., Flagan, R.C., Vahala, K.J.: Label-Free, Single-Molecule Detection with Optical Microcavities. Science 317, 783–787 (2007)
Jain, K.K.: The Handbook of Nanomedicine. Humana Press, Totowa (2008)
Hunter, P.J.: Modeling Human Physiology: The IUPS/EMBS Physiome Project. Proceedings of the IEEE 94, 678–691 (2006)
Prasad, P.N.: Introduction to Biophotonics. Wiley, Hoboken (2003)
Ligler, F.S..: Fluorescence-Based Optical Biosensors. In: Biophotonics, pp. 199–215. Springer, Berlin (2008)
Lambeck, P.V.: Integrated optical sensors for the chemical domain. Meas. Sci. Technol. 17, 93–116 (2006)
Lide, D.R. (ed.): CRC Handbook of Chemistry and Physics, 87th edn. Taylor & Francis, Bota Raton (2006)
Vollmer, F., Arnold, S.: Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nature Methods 5, 591–596 (2008)
Seitz, P.: Smart Pixel Arrays. In: Encyclopedia of Modern Optics, Elsevier, Oxford (2005)
Lotto, Ch., Seitz, P.: Synchronous and Asynchronous Detection of Ultra-Low Light Levels. In: Proceedings of the 2009 International Image Sensor Workshop, Bergen, Norway (2009)
Lee, M., Fauchet, P.M.: Two-dimensional silicon photonic crystal based biosensing platform for protein detection. Optics Express 15, 4530–4535 (2007)
De Vos, K., Bartoluzzi, I., Schacht, E., Bienstman, P., Baets, R.: Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. Optics Express 15, 7610–7615 (2007)
Choi, S.J., Peng, Z., Yang, Q., Choi, S.J., Dapkus, P.D.: Eight-Channel Microdisk CW Laser Arrays Vertically Coupled to Common Output Bus Waveguides. IEEE Photonics Technology Letters 16, 356–358 (2004)
Chinnayelka, S., McShane, N.J.: Competitive binding assays in microcapsules as smart tattoo biosensors. Proceedings of IEEE Sensors 2005, 1304–1307 (2005)
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© 2009 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering
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Seitz, P. (2009). Nanophotonics for Lab-on-Chip Applications. In: Schmid, A., Goel, S., Wang, W., Beiu, V., Carrara, S. (eds) Nano-Net. NanoNet 2009. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04850-0_22
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DOI: https://doi.org/10.1007/978-3-642-04850-0_22
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